Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury.

abstract：:Increases in the levels of proinflammatory cytokines, such as TNF alpha, have been intricately linked with arthritis and the pathogenesis of several models of neuropathic pain. In addition, arthritis (as well as other types of persistent pain) is associated with increased sympathetic activity and alterations of other ...

journal_title：Journal of neuroimmunology

authors： Chou RC,Dong XL,Noble BK,Knight PR,Spengler RN

更新日期：1998-03-01 00:00:00

abstract：:Microglial inflammation plays a pivotal role in the pathogenesis of S. aureus induced brain abscesses. The objective of this study was to regulate microglial activation by the combinatorial treatment of ciprofloxacin either with dexamethasone or celecoxib via targeting M1 and M2 polarization. The antibiotic-immunomodu...

journal_title：Journal of neuroimmunology

authors： Dey R,Bishayi B

更新日期：2020-07-15 00:00:00

abstract：:In order to study the role of interleukin-1beta (IL-1beta) in homeostasis, hypoxia and recovery of neuronal cells, we studied the expression and release of tumor necrosis factor-alpha (TNF-alpha) and nerve growth factor (NGF), in relation to the presence or absence of this cytokine in culture medium. Moreover, we eval...

journal_title：Journal of neuroimmunology

authors： Di Loreto S,Corvetti L,Maccarone R,Piancatelli D,Adorno D

更新日期：2000-07-01 00:00:00

abstract：:Myelin-reactive T helper-17 cells are implicated in the pathogenesis of multiple sclerosis (MS). Here, we analyzed the reactivity of peripheral naive and memory conventional CD4(+)CD127(high) T cells (Tconv) of MS patients and healthy controls (HC) towards myelin basic protein (MBP), myelin oligodendrocyte glycoprotei...

journal_title：Journal of neuroimmunology

authors： Venken K,Hellings N,Hensen K,Rummens JL,Stinissen P

更新日期：2010-09-14 00:00:00

abstract：:Unfractionated cytokines have been shown to induce in vitro proliferation of neonatal rat Schwann cells but the nature of the mitogen(s) is not known. A mixture of rabbit antibodies specific for recombinant interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) inhibited Schwann cell proliferation induced...

journal_title：Journal of neuroimmunology

authors： Lisak RP,Bealmear B

更新日期：1991-02-01 00:00:00

abstract：:We evaluated the brain volume and rate of atrophy in 85 Japanese patients with multiple sclerosis (MS). The mean brain volume was smaller and the rate of atrophy appeared to be more rapid in MS patients than in normal subjects. The brain atrophy seemed to exist from the early stage of MS and was prominent in the grey ...

journal_title：Journal of neuroimmunology

authors： Akaishi T,Nakashima I,Mugikura S,Aoki M,Fujihara K

更新日期：2017-05-15 00:00:00

abstract：:A significant reduction in the incidence of experimental allergic encephalomyelitis (EAE) in SJL/J mice was observed when mice were infected with lactic dehydrogenase virus (LDV) 14 days before, on day 0, or 3 days after immunization with spinal cord homogenate. These results are discussed in terms of the selective in...

journal_title：Journal of neuroimmunology

authors： Inada T,Mims CA

更新日期：1986-03-01 00:00:00

abstract：:A high proportion of peptide 1-11 specific T cells from H-2u (V beta 8+, H-2u) mice express the V beta 8 TCR chain. Peptide 89-101 is immunodominant for B10.RIII (V beta 8+, H-2r) mice; thus, it was of interest to determine whether V beta 8 TCR would be over-represented in a population of peptide 89-101-specific T cel...

journal_title：Journal of neuroimmunology

authors： Zhao ML,Xia JQ,Fritz RB

更新日期：1993-02-01 00:00:00

abstract：:The purposes of this study were to determine plasma and intestinal epinephrine (E) and norepinephrine (NE) concentrations in mice after exercise stress and, the effect of intravenous injection of E and NE (at concentrations during exercise) on viability of intestinal lymphocytes (IL). Exhaustive exercise significantly...

journal_title：Journal of neuroimmunology

authors： Marra S,Burnett M,Hoffman-Goetz L

更新日期：2005-01-01 00:00:00

abstract：:Clinical and experimental observations emphasize that inflammation is a direct risk factor for stroke. We performed a detailed histological and immunohistochemical analysis, assisted by digital morphometry, to compare the representative brain lesions in the ischemic core and penumbra in a rat model. Focal neuronal nec...

journal_title：Journal of neuroimmunology

authors： Horváth E,Huțanu A,Chiriac L,Dobreanu M,Orădan A,Nagy EE

更新日期：2018-11-15 00:00:00

abstract：:NFS/N mice infected with neurotropic Cas-Br-M murine leukemia virus (MuLV) at 21 days of age were resistant to neurologic disease and demonstrated MuLV-specific cytotoxic T lymphocyte (CTL) activity in spleen cells after in vitro stimulation. NFS/N mice infected with Cas-Br-M MuLV at 2 days of age failed to generate a...

journal_title：Journal of neuroimmunology

authors： Robbins DS,Hoffman PM

更新日期：1991-01-01 00:00:00

abstract：:Hemokinin 1 is encoded by preprotachykinin C (PPT-C) mRNA, and has been proposed as a regulator of B and T cell lymphopoiesis. Here we demonstrate the expression of mouse PPT-C mRNA by CD11b+ macrophages, CD11c+ dendritic cells and in the microglial cell line EOC 13.31. Expression was detected in freshly isolated CD11...

journal_title：Journal of neuroimmunology

authors： Nelson DA,Marriott I,Bost KL

更新日期：2004-10-01 00:00:00

abstract：:To assess whether TNF-alpha causes inflammatory demyelination or axonal degeneration, we injected into rat sciatic nerve saline, 100 U and 1000 U of rhTNF-alpha and studied the electrophysiological and pathological effects. At day 1 electrophysiology showed a slight reduction of proximal compound muscle action potenti...

journal_title：Journal of neuroimmunology

authors： Uncini A,Di Muzio A,Di Guglielmo G,De Angelis MV,De Luca G,Lugaresi A,Gambi D

更新日期：1999-02-01 00:00:00

abstract：:Childhood opsoclonus-myoclonus syndrome (OMS) occurs idiopathic or, in association with a neuroblastoma, as a paraneoplastic syndrome. Since autoantibodies were identified in some patients, an autoimmune pathogenesis has been suspected. While the newly discovered B-cell activating factors BAFF and APRIL are involved i...

journal_title：Journal of neuroimmunology

authors： Fühlhuber V,Bick S,Kirsten A,Hahn A,Gerriets T,Tschernatsch M,Kaps M,Preissner KT,Blaes F,Altenkämper S

更新日期：2009-05-29 00:00:00

abstract：:Research from our laboratory has demonstrated that the presentation of an aversive conditioned stimulus produces pronounced suppression of several in vitro measures of immune status. The present study was designed to evaluate the role of central corticotropin-releasing hormone (CRH) in the mechanisms mediating these c...

journal_title：Journal of neuroimmunology

authors： Perez L,Lysle DT

更新日期：1995-12-01 00:00:00

abstract：:Failure of CD95-mediated apoptosis as a potential negative regulatory mechanism of T cell expansion may be involved in T cell-mediated autoimmune diseases such as multiple sclerosis (MS). Recently, soluble CD95 has been shown to be elevated in MS patients with active disease. Here, we report that the sera of MS patien...

journal_title：Journal of neuroimmunology

authors： Zipp F,Otzelberger K,Dichgans J,Martin R,Weller M

更新日期：1998-06-15 00:00:00

abstract：:An altered peptide ligand (analog) of the encephalitogenic epitope of proteolipid protein residues 139-151 (p139-151) in which residues 144 and 147 are substituted with leucine and arginine, respectively (LR), protects from clinical but not histological experimental allergic encephalomyelitis (EAE). To understand in s...

journal_title：Journal of neuroimmunology

authors： Santambrogio L,Lees MB,Sobel RA

更新日期：1998-01-01 00:00:00

abstract：:The expression of several cell type-specific markers was studied by indirect immunofluorescence in discontinuous BSA gradient fractionated and unfractionated mouse cerebellar cells cultured for 3 days in vitro from embryonic day 13 through postnatal day 9. Cell surface antigen NS-4 and tetanus toxin receptors are pres...

journal_title：Journal of neuroimmunology

authors： Schnitzer J,Schachner M

更新日期：1981-12-01 00:00:00

abstract：:In this study, percentages of CD39(+) Treg and Th17 cells were compared between relapsing-remitting MS patients and controls and were related to the vitamin D status. The Th17 cell population was expanded in about 40% of the MS patients. In MS patients in remission, but not during relapse, a positive association was f...

journal_title：Journal of neuroimmunology

authors： Peelen E,Damoiseaux J,Smolders J,Knippenberg S,Menheere P,Tervaert JW,Hupperts R,Thewissen M

更新日期：2011-12-15 00:00:00

abstract：:Activation of microglia cells play critical role in neuroinflammation after brain injury. Exosomes from adipose-derived stem cells (ADSC) possess immunoregulation effect similar with ADSC. We hypothesized that ADSC derived exosomes (ADSC-exosomes) could inhibit the activation of microglia cells and prevent neuroinflam...

journal_title：Journal of neuroimmunology

authors： Feng N,Jia Y,Huang X

更新日期：2019-09-15 00:00:00

abstract：:PI-2301 is an immunomodulator that could be an alternative therapy for MS. A placebo-controlled, multiple-ascending dose, double-blind study was performed in patients with secondary-progressive MS. Treatment was given subcutaneously once weekly for 8 weeks, followed by a 4-week open-label treatment period with active ...

journal_title：Journal of neuroimmunology

authors： Kovalchin J,Krieger J,Genova M,Collins K,Augustyniak M,Masci A,Hittinger T,Kuca B,Edan G,Braudeau C,Rimbert M,Patel U,Mascioli E,Zanelli E

更新日期：2010-08-25 00:00:00

abstract：:The presence and severity of tardive dyskinesia were determined in 66 patients with chronic psychiatric disorders treated with chlorpromazine. The patients were classified according to the presence of antinuclear antibodies, the lupus anticoagulant, and the HLA antigen Bw44. The severity of orofacial dyskinesia was es...

journal_title：Journal of neuroimmunology

authors： Canoso RT,Romero JA,Yunis EJ

更新日期：1986-09-01 00:00:00

abstract：:2D-immunomics may be useful in the identification of autoantigens in neurological autoimmune diseases, but its application may be limited by denaturation of target proteins. Here we compared the capacity of a single or multiple antigens to elicit autoantibodies targeting multiple neural autoantigens by ELISA and 2D-im...

journal_title：Journal of neuroimmunology

authors： Farinazzo A,Gini B,Milli A,Ruffini F,Marconi S,Turano E,Anghileri E,Barbieri F,Cecconi D,Furlan R,Bonetti B

更新日期：2011-03-01 00:00:00

abstract：:Although it is known that neurotransmitters and neuropeptides can affect immune function in vitro, less is understood about how the neural environment affects immune function in the brain. Previously, we showed that regulation of parenchymal class II MHC after local injection of IFN-gamma is site-specific. In this com...

journal_title：Journal of neuroimmunology

authors： Phillips LM,Lampson LA

更新日期：1999-05-03 00:00:00

abstract：:Current immunotherapy of myasthenia gravis (MG) is often effective, but entails risks of infection and neoplasia. The "Guided Missile" strategy described here is designed to target and eliminate the individual's unique AChR-specific T cell repertoire, without otherwise interfering with the immune system. We geneticall...

journal_title：Journal of neuroimmunology

authors： Sun W,Adams RN,Miagkov A,Lu Y,Juon HS,Drachman DB

更新日期：2012-10-15 00:00:00

abstract：:Psychological and physical stress can alter the immune system in both humans and animals. We have reported that mice subjected to chronic 12-h daily physical restraint for 2 days showed dramatic apoptosis in splenocytes. To identify genes that contribute to the splenocyte apoptosis, we compare gene expression in the s...

journal_title：Journal of neuroimmunology

authors： Yin D,Zhang Y,Stuart C,Miao J,Zhang Y,Li C,Zeng X,Hanley G,Moorman J,Yao Z,Woodruff M

更新日期：2006-08-01 00:00:00

abstract：:Narcolepsy was first shown to be tightly associated with HLA-DR2 and DQ1 in 1983, suggesting a possible autoimmune mechanism. Early investigations failed to demonstrate this hypothesis, postulating that HLA-DR2 was only a linkage marker for another, unknown narcolepsy-causing gene. The autoimmune hypothesis is now bei...

journal_title：Journal of neuroimmunology

authors： Lin L,Hungs M,Mignot E

更新日期：2001-07-02 00:00:00

abstract：:Rasmussen's encephalitis (RE) is a rare condition characterized by drug-resistant seizures, recurrent status epilepticus and progressive lateralized neurological deterioration. There is evidence of autoimmune involvement in the pathogenesis. We investigated the presence of anti-GluR3 antibodies against peptides A and ...

journal_title：Journal of neuroimmunology

authors： Mantegazza R,Bernasconi P,Baggi F,Spreafico R,Ragona F,Antozzi C,Bernardi G,Granata T

更新日期：2002-10-01 00:00:00

abstract：:Macrophage colony-stimulating factor (M-CSF) is a critical cytokine in the development of monocytic lineage and may have immunoregulatory properties. Here we show that peritoneal antigen presenting cells (APCs) treated with M-CSF produced decreased levels of proinflammatory cytokines IFN-gamma, TNF-alpha and IL-12. Th...

journal_title：Journal of neuroimmunology

authors： Guan Y,Yu S,Zhao Z,Ciric B,Zhang GX,Rostami A

更新日期：2007-12-01 00:00:00

abstract：:Early diagnosis of multiple sclerosis (MS) may be assisted by tests for the abnormal immune responses of the central nervous system (CNS) including oligoclonal IgG bands in the cerebrospinal fluid (CSF), increased CNS IgG synthesis, increased CNS antibody synthesis against multiple viruses and increased numbers of enl...

journal_title：Journal of neuroimmunology

authors： Iivanainen MV

更新日期：1981-06-01 00:00:00