Intravenous catecholamine administration affects mouse intestinal lymphocyte number and apoptosis.

Abstract:

:The purposes of this study were to determine plasma and intestinal epinephrine (E) and norepinephrine (NE) concentrations in mice after exercise stress and, the effect of intravenous injection of E and NE (at concentrations during exercise) on viability of intestinal lymphocytes (IL). Exhaustive exercise significantly elevated plasma E and NE, and intestinal E, compared with sedentary animals. Twenty-four hours after intravenous NE administration, IL counts were higher (p<0.001) and % apoptotic IL were lower (p<0.001) than saline conditions. E resulted in fewer apoptotic IL at 24 h compared to saline controls. E and NE differentially influence IL numbers at 24 h after injection although both result in fewer % apoptotic IL relative to mice given saline only.

journal_name

J Neuroimmunol

authors

Marra S,Burnett M,Hoffman-Goetz L

doi

10.1016/j.jneuroim.2004.08.008

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

76-85

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(04)00286-3

journal_volume

158

pub_type

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