Role of the innate immune system in the pathogenesis of multiple sclerosis.

abstract：:Cellular adhesion molecules were initially defined as cell surface structures mediating cell-cell and cell-extracellular matrix (ECM) interactions. Adhesion molecules involved in immune responses have been classified into three families according to their structure: selectins, immunoglobulin (Ig) superfamily, and inte...

journal_title：Journal of neuroimmunology

authors： Lee SJ,Benveniste EN

更新日期：1999-08-03 00:00:00

abstract：:Although it is known that neurotransmitters and neuropeptides can affect immune function in vitro, less is understood about how the neural environment affects immune function in the brain. Previously, we showed that regulation of parenchymal class II MHC after local injection of IFN-gamma is site-specific. In this com...

journal_title：Journal of neuroimmunology

authors： Phillips LM,Lampson LA

更新日期：1999-05-03 00:00:00

abstract：:Ketamine is a potent anti-depressive agent. Nitric oxide plays an essential role in neuronal transmission and cerebral blood flow and has been implicated in the pathophysiology of major depressive disorder as well as cardiovascular functioning. We investigated the effect of ketamine on eNOS expression in human A172 as...

journal_title：Journal of neuroimmunology

authors： Yuhas Y,Ashkenazi S,Berent E,Weizman A

更新日期：2017-04-15 00:00:00

abstract：:We studied the effects of combination treatment with an anti-inflammatory agent, interferon (IFN)-beta, and a putative neuroprotective agent, an estrogen receptor (ER)-beta ligand, during EAE. Combination treatment significantly attenuated EAE disease severity, preserved axonal densities in spinal cord, and reduced CN...

journal_title：Journal of neuroimmunology

authors： Du S,Sandoval F,Trinh P,Voskuhl RR

更新日期：2010-02-26 00:00:00

abstract：:DNA damage-, DNA repair-, and apoptosis-related gene expression in CD3(+) T lymphocytes of BALB/c mice subjected to 2-h restraint stress were compared to that in CD3(+)T lymphocytes from control mice. Using targeted cDNA arrays, significant increases in expression of genes serving as sensors of DNA damage, including M...

journal_title：Journal of neuroimmunology

authors： Flint MS,Carroll JE,Jenkins FJ,Chambers WH,Han ML,Baum A

更新日期：2005-10-01 00:00:00

abstract：:We report here identification of novel mimicry epitopes for interphotoreceptor retinoid-binding protein (IRBP) 201-216, a candidate ocular antigen that causes experimental autoimmune uveoretinitis (EAU) in A/J mice. One mimicry epitope from Ehrlichia canis (EHC), designated EHC 44-59, induced cross-reactive T cells fo...

journal_title：Journal of neuroimmunology

authors： Gangaplara A,Massilamany C,Steffen D,Reddy J

更新日期：2013-10-15 00:00:00

abstract：:Degeneration of cholinergic neurons in the medial septum and the diagonal band of Broca is a frequent neuropathological feature of Alzheimer's disease. To determine whether an immune process can injure these basal forebrain cholinergic neurons, we serially immunized guinea pigs with septal cholinergic hybrid cells (SN...

journal_title：Journal of neuroimmunology

authors： Kálmán J,Engelhardt JI,Le WD,Xie W,Kovacs I,Kása P,Appel SH

更新日期：1997-07-01 00:00:00

abstract：:Only few reports are available on the epitope specificity of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in multiple sclerosis (MS). In the present study we provide a precise characterization of the epitope specificity of serum antibodies directed against the extracellular domain of MOG, including IgG, I...

journal_title：Journal of neuroimmunology

authors： Khalil M,Reindl M,Lutterotti A,Kuenz B,Ehling R,Gneiss C,Lackner P,Deisenhammer F,Berger T

更新日期：2006-05-01 00:00:00

abstract：:The multifaceted pathogenesis of multiple sclerosis (MS) involves complex interactions between the immune and the central nervous systems which provide a multitude of targets for therapeutic interventions. Current therapies for MS are only partially effective. One potential strategy to increase treatment efficacy is t...

journal_title：Journal of neuroimmunology

authors： Milo R,Panitch H

更新日期：2011-02-01 00:00:00

abstract：:The efficacy of plasma exchange as a therapy for Guillain-Barré syndrome (GBS) suggests that humoral factors might contribute to the axonal conduction block responsible for the major symptoms of the disease. To explore this possibility, we have applied sera to rat spinal roots in vitro while monitoring axonal conducti...

journal_title：Journal of neuroimmunology

authors： Dilley A,Gregson NA,Hadden RD,Smith KJ

更新日期：2003-06-01 00:00:00

abstract：:The effectiveness of T cell vaccination was analyzed in experimental autoimmune neuritis (EAN) that can be induced by immunization with bovine P2 protein or a peptide representing the amino acids 53-78 of P2 (P2 53-78). Lewis rats were vaccinated with glutaraldehyde-fixed lymph node cells which had been primed in vivo...

journal_title：Journal of neuroimmunology

authors： Jung S,Schluesener HJ,Toyka K,Hartung HP

更新日期：1991-12-01 00:00:00

abstract：:The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4+T-bet+ and CD8+T-bet+ T cells in SPMS and PPMS than in r...

journal_title：Journal of neuroimmunology

authors： Frisullo G,Plantone D,Marti A,Iorio R,Damato V,Nociti V,Patanella AK,Bianco A,Batocchi AP

更新日期：2012-08-15 00:00:00

abstract：:Based on gene expression data, we tested the P8A-CCL2 variant of the chemokine CCL2, able to interfere with the chemotactic properties of the parental molecule, in relapsing-remitting (RR)-EAE SJL. Only preventive treatment significantly delayed disease onset in a dose dependent manner. P8A-CCL2 administration, howeve...

journal_title：Journal of neuroimmunology

authors： Brini E,Ruffini F,Bergami A,Brambilla E,Dati G,Greco B,Cirillo R,Proudfoot AE,Comi G,Furlan R,Zaratin P,Martino G

更新日期：2009-04-30 00:00:00

abstract：:We investigated in multiple sclerosis the difference between two commonly used oral and intravenous steroid regimens on the level of adhesion molecule expression on blood T lymphocytes, the distribution of circulating T cell subsets, and the concentration of serum tumour necrosis factor alpha. Venous blood samples wer...

journal_title：Journal of neuroimmunology

authors： Pitzalis C,Sharrack B,Gray IA,Lee A,Hughes RA

更新日期：1997-04-01 00:00:00

abstract：:Neuronal damage mediated by the TRAIL-system might be involved in the pathogenesis of neuroinflammatory diseases of the central nervous system. Here we used an investigator-independent approach to quantify TRAIL-mediated death of total CNS cells and neurons in a living human brain slice culture system, a model which i...

journal_title：Journal of neuroimmunology

authors： Dörr J,Roth K,Zurbuchen U,Deisz R,Bechmann I,Lehmann TN,Meier S,Nitsch R,Zipp F

更新日期：2005-10-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR)-gamma agonists, including thiazolidinediones (TZDs) and 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)), have been shown to be effective in the treatment of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). This study ai...

journal_title：Journal of neuroimmunology

authors： Storer PD,Xu J,Chavis J,Drew PD

更新日期：2005-04-01 00:00:00

abstract：:We evaluated the concentration of antineuronal antibodies in paired cerebrospinal fluid (CSF) and serum samples from 19 patients with central and peripheral paraneoplastic neurological syndromes (PNS), using an enzyme linked immunosorbent assay (ELISA) employing recombinant antineuronal antigens (HuD, Yo, Ri, CV2/CRMP...

journal_title：Journal of neuroimmunology

authors： Stich O,Jarius S,Kleer B,Rasiah C,Voltz R,Rauer S

更新日期：2007-02-01 00:00:00

abstract：:Rat thymocytes incubated in RPMI medium for 120-300 min release a soluble factor of molecular weight below 10,000 Da which inhibits the binding of 3H-labeled muscarinic antagonists in an uncompetitive manner, i.e. it reduces maximal specific binding (Bmax) without changing the affinity of the ligand (KD). This factor ...

journal_title：Journal of neuroimmunology

authors： Maslinski W,Ryzewski J,Bartfai T

更新日期：1988-03-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a disease model of multiple sclerosis (MS) that is characterized by remittance and relapse of the disease and autoimmune and demyelinating lesions in the central nervous system (CNS). To better understand the mechanism of disease relapse, we induced acute and chronic ...

journal_title：Journal of neuroimmunology

authors： Jee Y,Yoon WK,Okura Y,Tanuma N,Matsumoto Y

更新日期：2002-07-01 00:00:00

abstract：:Over the past decade, remarkable progress has been made in our understanding of the pathogenesis of Miller Fisher syndrome (MFS), a clinical variant of Guillain Barré syndrome (GBS). MFS comprises the clinical triad of ataxia, areflexia and ophthalmoplegia. It is associated with acute-phase IgG antibodies to GQ1b and ...

journal_title：Journal of neuroimmunology

authors： Willison HJ,O'Hanlon GM

更新日期：1999-12-01 00:00:00

abstract：:The B7/CD28:CTLA-4 costimulatory pathway plays a critical role in determining the fate of immune responses (activation vs. down-regulation) and is a highly promising therapeutic target for treating autoimmune diseases. In this review, we highlight the mechanisms by which this costimulatory pathway operates emphasizing...

journal_title：Journal of neuroimmunology

authors： Karandikar NJ,Vanderlugt CL,Bluestone JA,Miller SD

更新日期：1998-08-14 00:00:00

abstract：:We have previously found a dramatic increase of corticotropin-releasing factor receptor (CRF-R1) production in splenic neutrophils of male C57BL/6N mice after application of an immunological stimulus. We demonstrate here that immobilization, a predominantly psychological stress, exhibited a similar effect. Shortly aft...

journal_title：Journal of neuroimmunology

authors： Radulovic M,Weber C,Spiess J

更新日期：2000-03-01 00:00:00

abstract：:Neuronal damage in Alzheimer's disease (AD) is thought to involve direct toxicity of beta-amyloid peptide (Abeta) and excitotoxicity involving NMDA receptors (NMDARs) and altered Ca(2+) dynamics. Inflammation agents produced by microglia or astrocytes and associated with senile plaques such as the cytokine interleukin...

journal_title：Journal of neuroimmunology

authors： Qiu Z,Gruol DL

更新日期：2003-06-01 00:00:00

abstract：:Resistance to experimental allergic encephalomyelitis (EAE) induction by homogenized myelin (MSCH) in complete Freund's adjuvant (CFA) and pertussigen (P) in SJL mice was seen 1 week after intravenous injection of PLP 139-151 coupled to spleen cells (PLP-ECDI-SP). Although this resistance could be transferred by splee...

journal_title：Journal of neuroimmunology

authors： Santambrogio L,Crisi GM,Leu J,Hochwald GM,Ryan T,Thorbecke GJ

更新日期：1995-05-01 00:00:00

abstract：:Opioid peptides have been reported by many laboratories to modulate in vitro and in vivo cell-mediated and humoral immune responses. However, less attention has been afforded to the class or classes of opioid receptors involved in these immunomodulatory effects. Previous studies by this laboratory indicated that beta-...

journal_title：Journal of neuroimmunology

authors： Morgan EL

更新日期：1996-03-01 00:00:00

abstract：:Transplantation of a pituitary graft under the kidney capsule and the resulting elevation of serum prolactin enhances the primary humoral antibody response to sheep red blood cells. Enhancement of the response is not due to marked changes in the percentage of T-cells and their subsets, B-cells, or the number of nuclea...

journal_title：Journal of neuroimmunology

authors： Cross RJ,Campbell JL,Roszman TL

更新日期：1989-11-01 00:00:00

abstract：:Reactive oxygen species (ROS) produced by activated microglia are deleterious to neurons. In this study, we studied the effect of Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin (MnTMPyP), a superoxide dismutase/catalase mimetic, on the lipopolysaccharide (LPS)-induced degeneration of dopaminergic neurons in rat mesencep...

journal_title：Journal of neuroimmunology

authors： Wang T,Liu B,Qin L,Wilson B,Hong JS

更新日期：2004-02-01 00:00:00

abstract：:Primary angiitis of the central nervous system (PACNS) is a rare and heterogeneous inflammatory disease of the CNS vasculature with poorly understood pathophysiology. Comprehensive immune-cell phenotyping revealed increased frequencies of leukocytes in the cerebrospinal fluid (CSF) of PACNS patients compared to patien...

journal_title：Journal of neuroimmunology

authors： Strunk D,Schulte-Mecklenbeck A,Golombeck KS,Meyer Zu Hörste G,Melzer N,Beuker C,Schmidt A,Wiendl H,Meuth SG,Gross CC,Minnerup J

更新日期：2018-08-15 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) has been reported to be expressed in various inflammatory disorders including human T cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-I-infected T-cells expressed high levels of MMP-9 via viral transactivator Tax mediated act...

journal_title：Journal of neuroimmunology

authors： Kodama D,Saito M,Matsumoto W,Sabouri AH,Izumo S,Arimura K,Usuku K,Bangham CR,Osame M

更新日期：2004-11-01 00:00:00

abstract：:VV(PLP) is a recombinant vaccinia virus (VV) encoding myelin proteolipid protein (PLP) that has been used to investigate molecular mimicry and autoimmunity. Since virus infections can cause bystander activation, mice were first infected with VV(PLP), and later challenged with wild-type VV, lymphocytic choriomeningitis...

journal_title：Journal of neuroimmunology

authors： Tsunoda I,Libbey JE,Fujinami RS

更新日期：2007-08-01 00:00:00