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Platelet-activating factor receptor gene polymorphism in Japanese patients with multiple sclerosis.

Abstract：

:We evaluated the association of the platelet-activating factor receptor (PAFR) gene polymorphism (A224D) with the susceptibility and severity of multiple sclerosis (MS) in a Japanese population. DNA was collected from 162 Japanese patients with clinically definite 'conventional' MS (MS) and 245 healthy controls. The missense mutation A224D that impairs PAF-PAFR signaling was determined by polymerase chain reaction restriction fragment length polymorphism. The frequency of the AD/DD genotypes was significantly higher in MS patients (21.0%) than in healthy controls (13.5%) (p=0.045; odds ratio (OR), 1.71; 95% confidence interval (CI), 1.01-2.89). Moreover, the frequency of D allele in MS patients (11.7%) was also significantly higher than those in healthy controls (6.9%) (p=0.019; OR, 1.78; 95% CI, 1.10-2.89). These findings suggest that the PAFR gene missense mutation has a relation to the susceptibility for MS.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Osoegawa M,Miyagishi R,Ochi H,Nakamura I,Niino M,Kikuchi S,Murai H,Fukazawa T,Minohara M,Tashiro K,Kira J

doi

10.1016/j.jneuroim.2004.12.014

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

195-8

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(05)00003-2

journal_volume

161

pub_type

杂志文章

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