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Interferon-gamma regulation of C3 gene expression in human astroglioma cells.

Abstract：

:In this report, we show that the human astroglioma cell line, D54-MG, constitutively expresses C3 mRNA and secretes antigenically detectable C3 protein. The cytokine interferon-gamma (IFN-gamma) enhances C3 mRNA and protein expression by D54-MG cells in a dose- and time-dependent manner. C3 mRNA from both D54-MG cells and primary human adult astrocytes has the same apparent size (5.1-5.2 kb) as C3 mRNA from hepatocyte and monocyte cell lines. Constitutive C3 mRNA levels in D54-MG cells and primary human astrocytes are comparable. Primary rat astrocytes also constitutively express C3 mRNA, which is enhanced upon exposure to IFN-gamma. These data are novel since expression of C3 in other cell types is refractory to IFN-gamma. In the central nervous system (CNS), endogenous complement production by astrocytes, and enhancement by the cytokine IFN-gamma, may contribute to the pathogenesis of inflammatory demyelinating diseases such as multiple sclerosis (MS).

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Barnum SR,Jones JL,Benveniste EN

doi

10.1016/0165-5728(92)90020-l

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

275-82

issue

3

eissn

0165-5728

issn

1872-8421

pii

0165-5728(92)90020-L

journal_volume

38

pub_type

杂志文章

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