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Specific immunotherapy of experimental myasthenia gravis in vitro and in vivo: the Guided Missile strategy.

Abstract：

:Current immunotherapy of myasthenia gravis (MG) is often effective, but entails risks of infection and neoplasia. The "Guided Missile" strategy described here is designed to target and eliminate the individual's unique AChR-specific T cell repertoire, without otherwise interfering with the immune system. We genetically engineered dendritic cells to present AChR epitopes and simultaneously express Fas ligand in an ongoing EAMG model. In both in vitro and in vivo experiments, these engineered cells specifically killed AChR-responsive T cells without otherwise damaging the immune system. AChR antibodies were markedly reduced in the treated mice. Translation of this method to treat human MG is possible.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Sun W,Adams RN,Miagkov A,Lu Y,Juon HS,Drachman DB

doi

10.1016/j.jneuroim.2012.06.007

subject

Has Abstract

pub_date

2012-10-15 00:00:00

pages

25-32

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(12)00190-7

journal_volume

251

pub_type

杂志文章

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