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Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in Guillain-Barré syndrome.

Abstract：

:Anti-galactocerebroside (GalC) antibodies are reported to be present in GBS patients with preceding Mycoplasma pneumoniae (MP) infection. We investigated the presence of anti-GalC reactivity in serum of a large group of GBS patients using ELISA and compared this with healthy controls and individuals with an uncomplicated MP infection. Anti-GalC antibody reactivity was present in 12% of the GBS patients. Furthermore, anti-GalC antibodies were associated with MP infections, a relatively mild form of the disease and demyelinating features. Anti-GalC antibodies cross-reacted with MP antigen. In conclusion, anti-GalC antibodies in GBS patients may be induced by molecular mimicry with MP.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Ang CW,Tio-Gillen AP,Groen J,Herbrink P,Jacobs BC,Van Koningsveld R,Osterhaus AD,Van der Meché FG,van Doorn PA

doi

10.1016/s0165-5728(02)00209-6

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

179-83

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572802002096

journal_volume

130

pub_type

杂志文章

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