T-cell-mediated epineurial vasculitis and humoral-mediated microangiopathy in cryoglobulinemic neuropathy.

abstract：:Autism spectrum disorders are a heterogeneous group of behaviorally defined disorders having complex etiologies. We previously reported a direct correlation between lower plasma levels of the immunoglobulins (Ig) IgG and IgM and increased severity of behavioral symptoms in children with autism. Our current objective w...

journal_title：Journal of neuroimmunology

authors： Heuer LS,Rose M,Ashwood P,Van de Water J

更新日期：2012-10-15 00:00:00

abstract：:Acute flaccid paralysis is a neuromuscular emergency characterized by rapidly worsening weakness that evolves quickly to cause diaphragmatic failure. The challenge for the treating physician is to stabilize the patient, generate the differential diagnosis and determine the management; all in quick time. Neurotoxic sna...

journal_title：Journal of neuroimmunology

authors： Sundar K,Venkatasubramanian S,Shanmugam S,Arthur P,Subbaraya R,Hazeena P

更新日期：2017-10-15 00:00:00

abstract：:T-cell subsets in the peripheral blood were analyzed using monoclonal antibodies during the development of experimental allergic neuritis in Lewis rats. Percentages of helper and suppressor cells and ratios of helper/suppressor cells did not exceed normal limits during the development of the disease. ...

journal_title：Journal of neuroimmunology

authors： Feasby TE,Mazaheri R,Hahn AF,Gilbert JJ,Stiller CR,Keown PA

更新日期：1984-06-01 00:00:00

abstract：:This study reports on the immunocytochemical localization of tumor necrosis factor-alpha (TNF alpha) in immune-mediated demyelination and Wallerian degeneration of the rat peripheral nervous system (PNS) using teased nerve fiber preparations. In experimental autoimmune neuritis induced by active immunization (EAN) or ...

journal_title：Journal of neuroimmunology

authors： Stoll G,Jung S,Jander S,van der Meide P,Hartung HP

更新日期：1993-06-01 00:00:00

abstract：:In this study the effect of long-term selective sensory vs. sympathetic denervation was examined in the rat lung. Immunoreactivities for calcitonin gene-related peptide (CGRP) on the one hand and tyrosine hydroxylase (TH) on the other, were used as indexes to assess the changes in the two nerve systems. Following long...

journal_title：Journal of neuroimmunology

authors： Van Ranst L,Lauweryns JM

更新日期：1990-09-01 00:00:00

abstract：:The neurologic sequelae of human immunodeficiency virus (HIV) infection may be divided into primary (= HIV-induced) and secondary (= opportunistic infections and malignancies) manifestations. Our experience with 215 HIV-infected patients indicates that major clinical symptoms are due to a few, albeit important, neurol...

journal_title：Journal of neuroimmunology

authors： Fischer PA,Enzensberger W

更新日期：1988-12-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) administration has been beneficially used in the treatment of several autoimmune disorders including myasthenia gravis (MG), although its mechanism of action is still not clear. To study the optimal conditions of IVIG treatment and delineate its mechanism of action we established a su...

journal_title：Journal of neuroimmunology

authors： Zhu KY,Feferman T,Maiti PK,Souroujon MC,Fuchs S

更新日期：2006-07-01 00:00:00

abstract：:The pharmacological profile and the anatomical localisation of muscarinic cholinergic receptor subtypes were studied in the pigeon bursa of Fabricius, using radioligand binding and autoradiographic techniques with [3H]quinuclidinyl benzilate (QNB) as a ligand. [3H]QNB was specifically bound to sections of bursa of Fab...

journal_title：Journal of neuroimmunology

authors： Ricci A,Bronzetti E,Felici L,Ciriaco E,Vega JA,Germanà G

更新日期：1996-05-01 00:00:00

abstract：:In this study we evaluated the percentages of CD3(-)CD56(bright), CD3(-)CD56(dim), CD3(-)CD56(bright)perforin(+) and CD3(-)CD56(dim)perforin(+) Natural Killer (NK) cells in peripheral blood from untreated secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) patients and age and sex matched h...

journal_title：Journal of neuroimmunology

authors： Plantone D,Marti A,Frisullo G,Iorio R,Damato V,Nociti V,Patanella AK,Bianco A,Mirabella M,Batocchi AP

更新日期：2013-12-15 00:00:00

abstract：:We examined the role of Notch ligand Delta-like 1 (Delta1) in the development of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD). Blocking of Delta1 by anti-Delta1 monoclonal antibody (mAb) in the effector phase significantly suppressed the disease development of TMEV-IDD both ...

journal_title：Journal of neuroimmunology

authors： Tsugane S,Takizawa S,Kaneyama T,Ichikawa M,Yagita H,Kim BS,Koh CS

更新日期：2012-11-15 00:00:00

abstract：:The pathogenesis of Alzheimer's disease (AD) includes the participation of the immune system. To identify antigenic targets in AD, we screened a human microvascular endothelial cell cDNA library with sera from patients with AD, and we identified rabaptin 5 (RABPT5). We detected serum IgG specific to RABPT5 in 65% of p...

journal_title：Journal of neuroimmunology

authors： Delunardo F,Margutti P,Pontecorvo S,Colasanti T,Conti F,Riganò R,Profumo E,Siracusano A,Capozzi A,Prencipe M,Sorice M,Francia A,Ortona E

更新日期：2007-12-01 00:00:00

abstract：:An electroimmunoblotting technique was used with a monoclonal antibody to myelin basic protein (MBP) to assess demyelination in 3 defined regions of the spinal cord in rats with acute experimental autoimmune encephalomyelitis (EAE). A slight loss in MBP was detected only in the sacrococcygeal region of the spinal cord...

journal_title：Journal of neuroimmunology

authors： Kerlero de Rosbo N,Bernard CC,Simmons RD,Carnegie PR

更新日期：1985-10-01 00:00:00

abstract：:Relative telomere length (TL) is regarded as a biomarker of biological age. Accelerated immune aging, as represented by TL reduction, has been demonstrated in autoimmune diseases, including multiple sclerosis (MS). However, it is still unresolved whether telomere shortening is the cause or the consequence of the patho...

journal_title：Journal of neuroimmunology

authors： Habib R,Ocklenburg S,Hoffjan S,Haghikia A,Epplen JT,Arning L

更新日期：2020-04-15 00:00:00

abstract：:We evaluated the association of the platelet-activating factor receptor (PAFR) gene polymorphism (A224D) with the susceptibility and severity of multiple sclerosis (MS) in a Japanese population. DNA was collected from 162 Japanese patients with clinically definite 'conventional' MS (MS) and 245 healthy controls. The m...

journal_title：Journal of neuroimmunology

authors： Osoegawa M,Miyagishi R,Ochi H,Nakamura I,Niino M,Kikuchi S,Murai H,Fukazawa T,Minohara M,Tashiro K,Kira J

更新日期：2005-04-01 00:00:00

abstract：:Altered peptide ligands (APL) with increased MHC-binding properties are highly effective at inducing T cell tolerance after systemic administration in soluble form, preventing experimental autoimmune encephalomyelitis (EAE) induced with the myelin basic protein (MBP) Ac1-9 peptide. We have previously described a diver...

journal_title：Journal of neuroimmunology

authors： McCue D,Ryan KR,Wraith DC,Anderton SM

更新日期：2004-11-01 00:00:00

abstract：:In this study, experimental allergic encephalomyelitis (EAE) rats and rats exhibiting EAE expressing high circulating anti-nerve growth factor antibody were daily monitored for clinical signs and chronic relapses. Eighty-five days after EAE induction, blood, spinal cord and brain stem were used for histological examin...

journal_title：Journal of neuroimmunology

authors： Micera A,Properzi F,Triaca V,Aloe L

更新日期：2000-05-01 00:00:00

abstract：:Myasthenia gravis (MG) is an autoimmune disorder caused by antibody-mediated attack against skeletal muscle nicotinic acetylcholine receptor (AchR) at neuromuscular junction. A close relationship exists between heat shock proteins (HSPs) and numerous autoimmune diseases. HSPs are over expressed to protect the host aga...

journal_title：Journal of neuroimmunology

authors： Patil SA,Katyayani S,Sood A,Kavitha AK,Marimuthu P,Taly AB

更新日期：2013-04-15 00:00:00

abstract：:We examined anti-complement C1q (C1q) autoantibody levels in serum and cerebrospinal fluid (CSF) samples of patients with neuromyelitis optica spectrum disorders (NMOSD). We analyzed the correlations between anti-C1q autoantibody levels and the clinical and other CSF characteristics of NMOSD. Serum and CSF anti-C1q au...

journal_title：Journal of neuroimmunology

authors： Yoshikura N,Kimura A,Hayashi Y,Inuzuka T

更新日期：2017-09-15 00:00:00

abstract：:We evaluated the impact of brain MRI findings and oligoclonal IgG bands (OCBs) on conversion to clinically definite multiple sclerosis (CDMS) in 26 Japanese patients with clinically isolated syndrome (CIS). 19.2% had OCBs positivity and 3.8% had fulfillment of Barkhof criteria at baseline. 60.0% of CIS patients with p...

journal_title：Journal of neuroimmunology

authors： Kinoshita M,Daifu M,Tanaka K,Tanaka M

更新日期：2017-06-15 00:00:00

abstract：:Three monoclonal antibodies reactive with human myelin basic protein have been used to develop immunoradiometric assays for this protein. Clone 1, a mouse IgG2a, is reactive with an epitope in the region 129-138. Clone 2, a mouse IgG1, is reactive with the region 119-131. Clone 12, a rat IgG, is reactive with the regi...

journal_title：Journal of neuroimmunology

authors： Groome NP,Dawkes A,Gales M,Hruby S,Alvord EC Jr

更新日期：1986-10-01 00:00:00

abstract：:Chronic-inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated disease with no known biomarkers for diagnosing the disease or assessing its prognosis. We performed transcriptional profiling microarray analysis on skin punch biopsies from 20 CIDP patients and 17 healthy controls to identify disease-asso...

journal_title：Journal of neuroimmunology

authors： Puttini S,Panaite PA,Mermod N,Renaud S,Steck AJ,Kuntzer T

更新日期：2014-05-15 00:00:00

abstract：:Serum levels of immunoreactive interleukin-2 (IL-2) were determined at monthly intervals from a group of placebo- and drug-treated chronic progressive multiple sclerosis patients before and during a cyclosporine A therapeutic trial. Significantly elevated levels of the lymphokine in active patients confirmed earlier s...

journal_title：Journal of neuroimmunology

authors： Trotter JL,van der Veen RC,Clifford DB

更新日期：1990-06-01 00:00:00

abstract：:PI-2301 is an immunomodulator that could be an alternative therapy for MS. A placebo-controlled, multiple-ascending dose, double-blind study was performed in patients with secondary-progressive MS. Treatment was given subcutaneously once weekly for 8 weeks, followed by a 4-week open-label treatment period with active ...

journal_title：Journal of neuroimmunology

authors： Kovalchin J,Krieger J,Genova M,Collins K,Augustyniak M,Masci A,Hittinger T,Kuca B,Edan G,Braudeau C,Rimbert M,Patel U,Mascioli E,Zanelli E

更新日期：2010-08-25 00:00:00

abstract：:The multifaceted pathogenesis of multiple sclerosis (MS) involves complex interactions between the immune and the central nervous systems which provide a multitude of targets for therapeutic interventions. Current therapies for MS are only partially effective. One potential strategy to increase treatment efficacy is t...

journal_title：Journal of neuroimmunology

authors： Milo R,Panitch H

更新日期：2011-02-01 00:00:00

abstract：:We have established a mouse experimental brain abscess model using Staphylococcus aureus where lesion sites are greatly exaggerated compared to the localized area of initial infection, reminiscent of an overactive immune response. Here we demonstrate the prolonged expression of IL-1 beta, TNF-alpha, and macrophage inf...

journal_title：Journal of neuroimmunology

authors： Baldwin AC,Kielian T

更新日期：2004-06-01 00:00:00

abstract：:Inflammatory mediators are involved in the pathogenesis of focal ischemic brain damage. In this study we used quantitative reverse transcriptase-polymerase chain reaction to analyze the spatiotemporal pattern of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and inducible nitric oxide synthase ...

journal_title：Journal of neuroimmunology

authors： Jander S,Schroeter M,Stoll G

更新日期：2000-09-22 00:00:00

abstract：:Ketamine is a potent anti-depressive agent. Nitric oxide plays an essential role in neuronal transmission and cerebral blood flow and has been implicated in the pathophysiology of major depressive disorder as well as cardiovascular functioning. We investigated the effect of ketamine on eNOS expression in human A172 as...

journal_title：Journal of neuroimmunology

authors： Yuhas Y,Ashkenazi S,Berent E,Weizman A

更新日期：2017-04-15 00:00:00

abstract：:Neurotuberculosis is one of the commonest HIV-associated opportunistic infections (OI) of the CNS. Cross-talk between HIV, Mycobacterium tuberculosis and host immune responses may alter expression of pattern recognition receptors (PRRs), thereby affecting cytokine profiles and functional responses. We examined PRR mRN...

journal_title：Journal of neuroimmunology

authors： Rao D,Vasanthapuram R,Satishchandra P,Desai A

更新日期：2018-05-15 00:00:00

abstract：:CSF and serum levels of soluble Fas were studied in MS patients, in patients with various neurological diseases and in healthy controls. We did not detect differences in serum sFas levels between MS patients and controls. In CSF, despite sFas levels being similar in all patients studied, a statistically significant co...

journal_title：Journal of neuroimmunology

authors： Ciusani E,Frigerio S,Gelati M,Corsini E,Dufour A,Nespolo A,La Mantia L,Milanese C,Massa G,Salmaggi A

更新日期：1998-02-01 00:00:00

abstract：:Activated CD4+ T lymphocytes specific for myelin basic protein (MBP) can cause experimental autoimmune encephalomyelitis (EAE) upon their inoculation into syngeneic recipients. In Lewis rats, most of the pathogenic T cell clones that develop following immunization with MBP are reactive against the 72-84 amino acid seq...

journal_title：Journal of neuroimmunology

authors： Beraud E,Balzano C,Zamora AJ,Varriale S,Bernard D,Ben-Nun A

更新日期：1993-08-01 00:00:00