Abstract：
:Relative telomere length (TL) is regarded as a biomarker of biological age. Accelerated immune aging, as represented by TL reduction, has been demonstrated in autoimmune diseases, including multiple sclerosis (MS). However, it is still unresolved whether telomere shortening is the cause or the consequence of the pathogenic events underlying autoimmunity. Assessing TL in whole blood DNA samples in 138 MS patients and 120 healthy controls showed reduced TL in patients as compared with controls There seems to be a prelude of accelerated telomere shortening, which may increase the risk for development of MS.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Habib R,Ocklenburg S,Hoffjan S,Haghikia A,Epplen JT,Arning Ldoi
10.1016/j.jneuroim.2020.577187subject
Has Abstractpub_date
2020-04-15 00:00:00pages
577187eissn
0165-5728issn
1872-8421pii
S0165-5728(19)30674-5journal_volume
341pub_type
杂志文章abstract：:The levels of the soluble (s) CD40:sCD40 ligand (L) dyad, which belongs to the tumor necrosis factor (TNF)-alpha:TNF-alpha-receptor superfamily, are significantly increased in the cerebrospinal fluid (CSF), but not the serum of cobalamin (Cbl)-deficient (Cbl-D) rats. They were normalized or significantly reduced after...
journal_title：Journal of neuroimmunology
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abstract：:Altered peptide ligands (APL) with increased MHC-binding properties are highly effective at inducing T cell tolerance after systemic administration in soluble form, preventing experimental autoimmune encephalomyelitis (EAE) induced with the myelin basic protein (MBP) Ac1-9 peptide. We have previously described a diver...
journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2004.07.010
更新日期：2004-11-01 00:00:00
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更新日期：2014-09-15 00:00:00
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journal_title：Journal of neuroimmunology
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更新日期：2004-03-01 00:00:00
abstract：:Human cytomegalovirus (CMV) infection is asymptomatic in immunocompetent individuals. However, it can lead to disease in immunodeficient population. Little is known of the mechanisms underlying the pathogenicity of the virus. We investigated the impact of CMV infection on mouse nervous system. Peripheral nerves but no...
journal_title：Journal of neuroimmunology
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doi：10.1016/j.jneuroim.2019.577017
更新日期：2019-10-15 00:00:00
abstract：:We tested the performance of MRZ-reaction, an intrathecal humoral immune response against-Measles (M), Rubella (R) and Varicella Zoster (Z) viruses, in multiple sclerosis (MS) diagnosis. The MRZ-reaction was significantly more positive in MS than in non-MS group with a specificity of 91.9%. In MS group, the RZ-profile...
journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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pub_type： 杂志文章
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abstract：:Little is known about antibody production within the central nervous system, called intrathecal antibody production (ITAbP). Mice infected with Theiler's murine encephalomyocarditis virus (TMEV) develop an immune-mediated demyelinating disease(TMEV-IDD), characterized by progressive weakness associated with robust ITA...
journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2007.09.001
更新日期：2007-10-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章,评审
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2008.11.003
更新日期：2009-01-03 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2017.07.006
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pub_type： 杂志文章
doi：10.1016/j.jneuroim.2010.06.014
更新日期：2010-10-08 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 临床试验,杂志文章
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更新日期：2005-12-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2016.12.017
更新日期：2017-04-15 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章,随机对照试验
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2003.10.040
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/j.jneuroim.2003.09.006
更新日期：2003-12-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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更新日期：2003-03-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/0165-5728(89)90132-x
更新日期：1989-12-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/0165-5728(83)90007-3
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/s0165-5728(96)00033-1
更新日期：1996-06-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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更新日期：2009-08-18 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2011-02-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/0165-5728(89)90155-0
更新日期：1989-01-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/s0165-5728(99)00125-3
更新日期：1999-10-29 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章,评审
doi：10.1016/j.jneuroim.2018.07.002
更新日期：2018-10-15 00:00:00
abstract：:In this study the effect of long-term selective sensory vs. sympathetic denervation was examined in the rat lung. Immunoreactivities for calcitonin gene-related peptide (CGRP) on the one hand and tyrosine hydroxylase (TH) on the other, were used as indexes to assess the changes in the two nerve systems. Following long...
journal_title：Journal of neuroimmunology
pub_type： 杂志文章
doi：10.1016/0165-5728(90)90155-g
更新日期：1990-09-01 00:00:00
