Activation thresholds determine susceptibility to peptide-induced tolerance in a heterogeneous myelin-reactive T cell repertoire.

Abstract:

:Altered peptide ligands (APL) with increased MHC-binding properties are highly effective at inducing T cell tolerance after systemic administration in soluble form, preventing experimental autoimmune encephalomyelitis (EAE) induced with the myelin basic protein (MBP) Ac1-9 peptide. We have previously described a diverse Ac1-9-reactive T cell repertoire with differing TCR affinities. A remaining question is what proportion of this repertoire is silenced by peptide therapy? Here, we show that the sensitivity of a T cell to peptide-induced tolerance is related to its avidity for native Ac1-9. These data provide new evidence that self-reactive T cells bearing low-affinity TCRs are able to escape therapeutic induction of tolerance.

journal_name

J Neuroimmunol

authors

McCue D,Ryan KR,Wraith DC,Anderton SM

doi

10.1016/j.jneuroim.2004.07.010

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

96-106

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(04)00251-6

journal_volume

156

pub_type

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