Activation thresholds determine susceptibility to peptide-induced tolerance in a heterogeneous myelin-reactive T cell repertoire.


:Altered peptide ligands (APL) with increased MHC-binding properties are highly effective at inducing T cell tolerance after systemic administration in soluble form, preventing experimental autoimmune encephalomyelitis (EAE) induced with the myelin basic protein (MBP) Ac1-9 peptide. We have previously described a diverse Ac1-9-reactive T cell repertoire with differing TCR affinities. A remaining question is what proportion of this repertoire is silenced by peptide therapy? Here, we show that the sensitivity of a T cell to peptide-induced tolerance is related to its avidity for native Ac1-9. These data provide new evidence that self-reactive T cells bearing low-affinity TCRs are able to escape therapeutic induction of tolerance.


J Neuroimmunol


McCue D,Ryan KR,Wraith DC,Anderton SM




Has Abstract


2004-11-01 00:00:00














  • Experimental autoimmune encephalomyelitis induced in B6.C-H-2bm12 mice by myelin oligodendrocyte glycoprotein: effect of MHC class II mutation on immunodominant epitope selection and fine epitope specificity of encephalitogenic T cells.

    abstract::The effect of the bm12 mutation on susceptibility to MOG-induced EAE, TCR repertoire and fine epitope specificity of the encephalitogenic T-cells, was assessed. prMOG35-55 was encephalitogenic for H-2bm12 and H-2b mice. Despite only minor differences in TCRVbeta expression and fine epitope specificity, H-2bm12/ and H-...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Mendel I,Gur H,Kerlero de Rosbo N,Ben-Nun A

    更新日期:1999-04-01 00:00:00

  • Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis.

    abstract::Eicosapentaenoic acid (EPA), one of the n-3 polyunsaturated fatty acids, is a neuroprotective lipid with anti-inflammatory properties. We investigated the possible therapeutic effect of EPA on experimental autoimmune encephalomyelitis (EAE). EAE mice were fed a diet with or without EPA. The clinical EAE scores of the ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Unoda K,Doi Y,Nakajima H,Yamane K,Hosokawa T,Ishida S,Kimura F,Hanafusa T

    更新日期:2013-03-15 00:00:00

  • Epstein-Barr virus and multiple sclerosis: cellular immune response and cross-reactivity.

    abstract::We investigated T cell immunity to Epstein-Barr virus (EBV) in multiple sclerosis (MS) and assessed cross-reactivity of the anti-EBV cellular response with brain antigens. We measured the proliferation, cytotoxicity, and number of interferon-γ secreting cells following stimulation with autologous EBV-infected lymphobl...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Lindsey JW,Hatfield LM

    更新日期:2010-12-15 00:00:00

  • Attempted isolation of viruses from myasthenia gravis thymus.

    abstract::A systematic study of thymus homogenates and cell suspensions from 13 patients with myasthenia gravis (MG) of recent onset, and 6 non-myasthenic controls, has failed to detect or isolate virus by cell culture with 'rescue techniques', electron microscopy, or intracerebral inoculation into neonatal mice. These results ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Klavinskis LS,Willcox HN,Richmond JE,Newsom-Davis J

    更新日期:1986-06-01 00:00:00

  • Dopamine, vesicular transporters and dopamine receptor expression and localization in rat thymus and spleen.

    abstract::The localization of dopamine stores and the expression and localization of vesicular monoamine transporter (VMAT) type-1 and 2 and of dopamine D1-like and D2-like receptor subtypes were investigated in rat thymus and spleen by immunohistochemical, immunochemical techniques and by RT-PCR. In the thymus dopamine immunor...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Mignini F,Tomassoni D,Traini E,Amenta F

    更新日期:2009-01-03 00:00:00

  • Differentiation of skeletal muscle from dissociated optic nerve cells. Immunocytochemical observations.

    abstract::Multinucleate striated contractile fibers which exhibit differentiation markers characteristic of skeletal muscle develop regularly in optic nerve cultured from 10-day-old rats. In identical conditions, muscle fibers arise also from pineal and occasionally from spinal cord, but not from meninges, cerebral blood vessel...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Wier ML,Lennon VA

    更新日期:1981-03-01 00:00:00

  • Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation.

    abstract::Reactive oxygen intermediates (ROIs) are important mediators of a variety of pathological processes, including inflammation and ischemia/reperfusion injury. Cytokines and chemokines are detected at mRNA level in human and animal ischemic brains. This suggests that hypoxia/reoxygenation may induce cytokine production t...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Wang MJ,Huang HM,Hsieh SJ,Jeng KC,Kuo JS

    更新日期:2001-01-01 00:00:00

  • Modulation of acetylcholine receptor function in TE671 (rhabdomyosarcoma) cells by non-AChR ligands: possible relevance to seronegative myasthenia gravis.

    abstract::The acetylcholine receptor (AChR) is the main target antigen in myasthenia gravis (MG), but about 15% of patients with typical immunologically mediated MG do not have detectable anti-AChR antibodies. Previous studies showed that plasma from these 'seronegative' patients (SNMG) reduced AChR function in the human AChR-e...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Li Z,Forester N,Vincent A

    更新日期:1996-02-01 00:00:00

  • Involvement of natural cytotoxicity receptors in human natural killer cell-mediated lysis of neuroblastoma and glioblastoma cell lines.

    abstract::The surface receptors involved in natural killer (NK) cell triggering during the process of target cell lysis have been at least in part identified. These are members of a novel family of receptors that has been termed natural cytotoxicity receptors (NCR). The first three members of this emerging group of receptors ar...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Sivori S,Parolini S,Marcenaro E,Castriconi R,Pende D,Millo R,Moretta A

    更新日期:2000-07-24 00:00:00

  • Induction of TRAIL-mediated glioma cell death by human T cells.

    abstract::Among the death ligands of the tumor necrosis factor/nerve growth factor (TNF/NGF) superfamily, TNF-related apoptosis-inducing ligand (TRAIL) is considered to play a unique role due to its binding to both apoptosis-inducing and -blocking membranous receptors, apoptosis-independent effects and distinct species differen...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Dörr J,Waiczies S,Wendling U,Seeger B,Zipp F

    更新日期:2002-01-01 00:00:00

  • Differential effector and secretory functions of microglial cell lines derived from BCG-resistant and -susceptible congenic mouse strains.

    abstract::Using congenic strains of mice susceptible (bcg(s)) or resistant (bcg(r)) to BCG, murine microglial cell lines, RR4.R (BCG-resistant) and RR8.S (BCG-susceptible), were established in vitro. Comparative studies revealed that, although phagocytic to a similar extent, RR4.R cells were more active than RR8.S cells in term...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Puliti M,Mazzolla R,Brozzetti A,Neglia R,Radzioch D,Bistoni F,Blasi E

    更新日期:1999-11-01 00:00:00

  • Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cells.

    abstract::Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles. In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compa...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Calabresi PA,Yun SH,Allie R,Whartenby KA

    更新日期:2002-06-01 00:00:00

  • CD44 splice variant involvement in the chronic inflammatory disease of the spinal cord: HAM/TSP.

    abstract::Splice variants of CD44 molecule-harboring exon 10 (v6), often called v6 variants (v6v), are shown to confer tumor progressive, metastatic or invasive capacities. Furthermore, CD44 molecule on activated T-cells are shown to be required for infiltration of these cells into the inflammatory site and for accelerated immu...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Matsuoka E,Usuku K,Jonosono M,Takenouchi N,Izumo S,Osame M

    更新日期:2000-01-03 00:00:00

  • Combination therapy in multiple sclerosis.

    abstract::The multifaceted pathogenesis of multiple sclerosis (MS) involves complex interactions between the immune and the central nervous systems which provide a multitude of targets for therapeutic interventions. Current therapies for MS are only partially effective. One potential strategy to increase treatment efficacy is t...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: Milo R,Panitch H

    更新日期:2011-02-01 00:00:00

  • Variable patterns of anti-GM(1) IgM-antibody populations defined by affinity and fine specificity in patients with motor syndromes: evidence for their random origin.

    abstract::Elevated titers of serum antibodies against GM(1)-ganglioside are associated with a variety of autoimmune neuropathies. Although much evidence indicates that these autoantibodies play a primary role in the disease processes, the mechanism of their appearance is unclear. Low-affinity anti-GM(1) antibodies of the IgM is...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Lopez PH,Lardone RD,Irazoqui FJ,Villa AM,Di Egidio M,Saizar RD,Sica RE,Nores GA

    更新日期:2001-09-03 00:00:00

  • False-positive acetylcholine receptor antibody results in patients without myasthenia gravis.

    abstract::Acetylcholine receptor antibodies are very specific for myasthenia. During a large prospective cohort study of myasthenia, we encountered five patients, positive for acetylcholine receptor (AChR) antibodies by radioimmunoprecipitation assay (RIA), whose clinical course revealed diagnoses other than myasthenia. Two pat...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Maddison P,Sadalage G,Ambrose PA,Jacob S,Vincent A

    更新日期:2019-07-15 00:00:00

  • γδ T lymphocytes in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis.

    abstract::The aim of the current review is to summarize the results of studies on the role of γδ T cells in the pathogenesis of multiple sclerosis and its animal model - the experimental autoimmune encephalomyelitis. Despite the fact that numerous studies have been performed, the role of γδ T is still not fully understood. It s...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: Zarobkiewicz MK,Kowalska W,Roliński J,Bojarska-Junak AA

    更新日期:2019-05-15 00:00:00

  • Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS.

    abstract::Intranasal application of vesicular stomatitis virus (VSV) induces acute encephalitis characterized by a pronounced myeloid and T cell infiltrate. The role of distinct phagocytic populations on VSV encephalitis was therefore examined in this study. Ablation of peripheral macrophages did not impair VSV encephalitis or ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Steel CD,Kim WK,Sanford LD,Wellman LL,Burnett S,Van Rooijen N,Ciavarra RP

    更新日期:2010-09-14 00:00:00

  • Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat.

    abstract::Although it is generally accepted that pro-inflammatory cytokines produced by cells of the central nervous system play important roles in the communication between the central nervous system and the immune system during sepsis, it is not clear whether these cytokines are produced in the brain under subseptic condition...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Quan N,Stern EL,Whiteside MB,Herkenham M

    更新日期:1999-01-01 00:00:00

  • Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation.

    abstract::The immunosuppressive nature of glucocorticoids has been well documented both in vitro and in vivo. This glucocorticoid-mediated immunosuppression has also been observed in immune cells within the central nervous system (CNS). For example, microglia have previously been shown to exhibit decreased proliferation, cytoki...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Nair A,Bonneau RH

    更新日期:2006-02-01 00:00:00

  • Immunogenetic markers in chlorpromazine-induced tardive dyskinesia.

    abstract::The presence and severity of tardive dyskinesia were determined in 66 patients with chronic psychiatric disorders treated with chlorpromazine. The patients were classified according to the presence of antinuclear antibodies, the lupus anticoagulant, and the HLA antigen Bw44. The severity of orofacial dyskinesia was es...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Canoso RT,Romero JA,Yunis EJ

    更新日期:1986-09-01 00:00:00

  • Multiple sclerosis is associated with high levels of circulating dendritic cells secreting pro-inflammatory cytokines.

    abstract::Recent evidence emphasises a pivotal role for dendritic cells (DC) in the control of immunity by priming and tolerising T cells. DC capture and process antigens, express co-stimulatory molecules, migrate to lymphoid organs and secrete cytokines to initiate immune responses. In multiple sclerosis (MS), autoreactive T c...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Huang YM,Xiao BG,Ozenci V,Kouwenhoven M,Teleshova N,Fredrikson S,Link H

    更新日期:1999-09-01 00:00:00

  • Morphine synergizes with lipopolysaccharide in a chronic endotoxemia model.

    abstract::Emergent or elective surgical procedures may be complicated by sepsis, resulting in critical illness that can lead to organ failure and death. The opioid drug, morphine is widely used to alleviate pain in post-surgical patients; however, it is well documented that chronic treatment of mice with morphine affects the pr...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Roy S,Charboneau RG,Barke RA

    更新日期:1999-03-01 00:00:00

  • Regional difference in inflammatory response to LPS-injection in the brain: role of microglia cell density.

    abstract::To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays using three different densities of N13 microglia stimulated with LPS. Our results showed that induction of pro-inflammatory factors as TNF-α and iNOS was directly related to cell density, meanwhi...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Pintado C,Revilla E,Vizuete ML,Jiménez S,García-Cuervo L,Vitorica J,Ruano D,Castaño A

    更新日期:2011-09-15 00:00:00

  • Acute infusion of chemotactic or enkephalin-analog peptides into rat cerebral ventricles: scanning and transmission electron microscopy of leukocyte immigration in vivo.

    abstract::Acute infusions of the formylated chemotactic peptide formyl-methionyl-leucyl-phenylalanine-lysine (FMLPL) or enkephalin analogue (Sandoz peptide) were made to the lateral cerebral ventricle of adult male rats to examine potential cellular responses within the central nervous system (CNS). Ependymal regions lining the...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Saland LC,Van Epps DE,Maez D,Gutierrez L,Samora A

    更新日期:1988-06-01 00:00:00

  • Serotonergic aspects of the response of human platelets to immune-adjuvant muramyl dipeptide.

    abstract::The human platelet serotonergic responses of aggregation and uptake were shown to be modulated by muramyl peptides. Muramyl dipeptide inhibited serotonin uptake in a temperature dependent and stereospecific manner. It also blocked the binding to platelets of [3H]imipramine, a well-known inhibitor of serotonin uptake. ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Polanski M,Karnovsky ML

    更新日期:1992-03-01 00:00:00

  • Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system.

    abstract::After an injury to the central nervous system (CNS), activated microglia have been shown to contribute to the ongoing destructive processes leading to secondary neuronal degeneration. They can, however, also express neuroprotective activity. Studies from our laboratory point to the existence of a physiological T cell-...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Shaked I,Porat Z,Gersner R,Kipnis J,Schwartz M

    更新日期:2004-01-01 00:00:00

  • Studies on the intrathecal humoral immune response in canine distemper encephalitis.

    abstract::Albumin and IgG were quantitated in paired cerebrospinal fluid (CSF) and serum samples from dogs with demyelinating canine distemper virus (CDV) infection by means of rocket immunoelectrophoresis. The IgG index as indicator for intrathecal immunoglobulin synthesis was normal in animals with non-inflammatory demyelinat...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Vandevelde M,Zurbriggen A,Steck A,Bichsel P

    更新日期:1986-03-01 00:00:00

  • Mimicry epitope from Ehrlichia canis for interphotoreceptor retinoid-binding protein 201-216 prevents autoimmune uveoretinitis by acting as altered peptide ligand.

    abstract::We report here identification of novel mimicry epitopes for interphotoreceptor retinoid-binding protein (IRBP) 201-216, a candidate ocular antigen that causes experimental autoimmune uveoretinitis (EAU) in A/J mice. One mimicry epitope from Ehrlichia canis (EHC), designated EHC 44-59, induced cross-reactive T cells fo...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Gangaplara A,Massilamany C,Steffen D,Reddy J

    更新日期:2013-10-15 00:00:00

  • Effects of long-term sensory vs. sympathetic denervation on the distribution of calcitonin gene-related peptide and tyrosine hydroxylase immunoreactivities in the rat lung.

    abstract::In this study the effect of long-term selective sensory vs. sympathetic denervation was examined in the rat lung. Immunoreactivities for calcitonin gene-related peptide (CGRP) on the one hand and tyrosine hydroxylase (TH) on the other, were used as indexes to assess the changes in the two nerve systems. Following long...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Van Ranst L,Lauweryns JM

    更新日期:1990-09-01 00:00:00