Abstract:
:Altered peptide ligands (APL) with increased MHC-binding properties are highly effective at inducing T cell tolerance after systemic administration in soluble form, preventing experimental autoimmune encephalomyelitis (EAE) induced with the myelin basic protein (MBP) Ac1-9 peptide. We have previously described a diverse Ac1-9-reactive T cell repertoire with differing TCR affinities. A remaining question is what proportion of this repertoire is silenced by peptide therapy? Here, we show that the sensitivity of a T cell to peptide-induced tolerance is related to its avidity for native Ac1-9. These data provide new evidence that self-reactive T cells bearing low-affinity TCRs are able to escape therapeutic induction of tolerance.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
McCue D,Ryan KR,Wraith DC,Anderton SMdoi
10.1016/j.jneuroim.2004.07.010subject
Has Abstractpub_date
2004-11-01 00:00:00pages
96-106issue
1-2eissn
0165-5728issn
1872-8421pii
S0165-5728(04)00251-6journal_volume
156pub_type
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