Activation thresholds determine susceptibility to peptide-induced tolerance in a heterogeneous myelin-reactive T cell repertoire.

Abstract:

:Altered peptide ligands (APL) with increased MHC-binding properties are highly effective at inducing T cell tolerance after systemic administration in soluble form, preventing experimental autoimmune encephalomyelitis (EAE) induced with the myelin basic protein (MBP) Ac1-9 peptide. We have previously described a diverse Ac1-9-reactive T cell repertoire with differing TCR affinities. A remaining question is what proportion of this repertoire is silenced by peptide therapy? Here, we show that the sensitivity of a T cell to peptide-induced tolerance is related to its avidity for native Ac1-9. These data provide new evidence that self-reactive T cells bearing low-affinity TCRs are able to escape therapeutic induction of tolerance.

journal_name

J Neuroimmunol

authors

McCue D,Ryan KR,Wraith DC,Anderton SM

doi

10.1016/j.jneuroim.2004.07.010

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

96-106

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(04)00251-6

journal_volume

156

pub_type

杂志文章
  • Cytokine-like effects of prolactin in human mononuclear and polymorphonuclear leukocytes.

    abstract::Some biochemical events following the binding of prolactin (PRL) to its receptor in normal human leukocytes were investigated. PRL enhanced JAK2 phosphorylation in peripheral blood mononuclear cells (PBMC) but not in granulocytes. PRL also induced phosphorylation of Stat-5 in PBMC and Stat-1 in granulocytes. Subsequen...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(01)00420-9

    authors: Dogusan Z,Hooghe R,Verdood P,Hooghe-Peters EL

    更新日期:2001-11-01 00:00:00

  • Cytokines in cerebrospinal fluid of neurosyphilis patients: Identification of Urokinase plasminogen activator using antibody microarrays.

    abstract::Little is known regarding protein responses to syphilis infection in cerebrospinal fluid (CSF) of patients presenting with neurosyphilis. Protein and antibody arrays offer a new opportunity to gain insights into global protein expression profiles in these patients. Here we obtained CSF samples from 46 syphilis patient...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2015.12.010

    authors: Lu P,Zheng DC,Fang C,Huang JM,Ke WJ,Wang LY,Zeng WY,Zheng HP,Yang B

    更新日期:2016-04-15 00:00:00

  • Tumor necrosis factor-alpha in immune-mediated demyelination and Wallerian degeneration of the rat peripheral nervous system.

    abstract::This study reports on the immunocytochemical localization of tumor necrosis factor-alpha (TNF alpha) in immune-mediated demyelination and Wallerian degeneration of the rat peripheral nervous system (PNS) using teased nerve fiber preparations. In experimental autoimmune neuritis induced by active immunization (EAN) or ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(93)90178-2

    authors: Stoll G,Jung S,Jander S,van der Meide P,Hartung HP

    更新日期:1993-06-01 00:00:00

  • Immunological patterns identifying disease course and evolution in multiple sclerosis patients.

    abstract::Reliable, and easy to measure, immunological markers able to denote disease characteristics in multiple sclerosis (MS) patients are still lacking. We applied a multivariate statistical analysis on results obtained by measuring-by real-time RT-PCR-mRNA levels of 25 immunological relevant molecules in PBMCs from 198 MS ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2005.04.012

    authors: Furlan R,Rovaris M,Martinelli Boneschi F,Khademi M,Bergami A,Gironi M,Deleidi M,Agosta F,Franciotta D,Scarpini E,Uccelli A,Zaffaroni M,Kurne A,Comi G,Olsson T,Filippi M,Martino G

    更新日期:2005-08-01 00:00:00

  • Studies on terminal deoxynucleotidyl transferase and adenosine deaminase in myasthenic thymus.

    abstract::Thymic function in myasthenic patients was examined using two biochemical markers which specifically define a population of cortisone-sensitive cortical thymocytes. The enzymatic activities of terminal deoxynucleotidyl transferase (TdT) and adenosine deaminase (ADA) were determined in 13 samples. High contents of both...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(84)90067-5

    authors: Vezzoni P,Fiacchino F,Clerici L,Sghirlanzoni A,Cerrato D,Peluchetti D,Lucchini R,Raineri M,Cornelio F

    更新日期:1984-09-01 00:00:00

  • Experimental autoimmune encephalomyelitis induced in B6.C-H-2bm12 mice by myelin oligodendrocyte glycoprotein: effect of MHC class II mutation on immunodominant epitope selection and fine epitope specificity of encephalitogenic T cells.

    abstract::The effect of the bm12 mutation on susceptibility to MOG-induced EAE, TCR repertoire and fine epitope specificity of the encephalitogenic T-cells, was assessed. prMOG35-55 was encephalitogenic for H-2bm12 and H-2b mice. Despite only minor differences in TCRVbeta expression and fine epitope specificity, H-2bm12/ and H-...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(99)00009-0

    authors: Mendel I,Gur H,Kerlero de Rosbo N,Ben-Nun A

    更新日期:1999-04-01 00:00:00

  • Involvement of p38 MAPK signaling pathway in IFN-gamma and HTLV-I expression in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis.

    abstract::We analyzed the relationship between the expression of interferon (IFN)-gamma and HTLV-I p19 antigen and activation of p38 mitogen-activated protein kinase (p38 MAPK) in two HTLV-I-infected T cell lines derived from two patients (HCT-1 and HCT-4) with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2004.10.007

    authors: Fukushima N,Nishiura Y,Nakamura T,Yamada Y,Kohno S,Eguchi K

    更新日期:2005-02-01 00:00:00

  • Human myelin basic protein specific T cell lines display differential cytotoxicity against astrocytes, but are consistently cytotoxic against monocytes.

    abstract::In experimental allergic encephalomyelitis (EAE) myelin basic protein (MBP) specific T cells differ in their encephalitogenic potential. To investigate the functional diversity of human MBP specific T cell lines, we analysed their cytotoxic activity against human astrocytes and monocytes. Five out of 14 MBP specific T...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(98)00093-9

    authors: Weber F,Huber S,Aloisi F,Meinl E

    更新日期:1998-08-01 00:00:00

  • Chemokine CXCL8 modulates GluR1 phosphorylation.

    abstract::The chemokine interleukin 8/CXCL8 induces the phosphorylation of the GluR1 subunit of the AMPA-type glutamate receptor in neurons and transfected HEK cells, on both serine 845 (S845) and 831 (S831) residues. We previously described that CXCL8 receptor CXCR2 and GluR1 co-precipitate and that GluR1/CXCR2 co-expression b...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2008.04.017

    authors: Catalano M,Trettel F,Cipriani R,Lauro C,Sobrero F,Eusebi F,Limatola C

    更新日期:2008-07-31 00:00:00

  • Relation of intrathecal oligoclonal band production to inflammatory mediator and immunotherapy response in 208 children with OMS.

    abstract::In 208 children with opsoclonus-myoclonus syndrome (OMS), CSF IgG oligoclonal bands (OCB) and 22 immunomarkers in CSF and 21 in serum/blood were measured. In 36 untreated OMS, 58% were OCB(+), whereas 55% of treated OMS were OCB(-). OCB positivity or negativity did not alter concentrations or frequencies of immunomark...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2018.04.007

    authors: Pranzatelli MR,McGee NR,Tate ED

    更新日期:2018-08-15 00:00:00

  • Fatigue favors in vitro Th1 and Th17-like cell expansion and reduces corticoid sensitivity in MS patients.

    abstract::Fatigue is a common "ghost" symptom in patients with multiple sclerosis (MS), an autoimmune disease mediated by T cells that target myelin antigens of the central nervous system. As fatigue has been associated with inflammatory states, its occurrence may negatively impact MS progression. The aim of this study was to e...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2016.12.013

    authors: Alvarenga-Filho H,Salles M,Hygino J,Ferreira TB,Sacramento PM,Monteiro C,Vasconcelos CC,Alvarenga RM,Bento CA

    更新日期:2017-02-15 00:00:00

  • Glial transforming growth factor (TGF)-beta isotypes in multiple sclerosis: differential glial expression of TGF-beta 1, 2 and 3 isotypes in multiple sclerosis.

    abstract::We studied glial transforming growth factor (TGF)-beta isotype expression in 14 cases of multiple sclerosis. Acute active lesions exhibited selective TGF-beta 2 immunoreactivity of lesion encircling ramified microglia. In contrast, astrocytes within chronic active white matter lesions expressed all three isotypes. Chr...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(96)00135-x

    authors: Peress NS,Perillo E,Seidman RJ

    更新日期:1996-12-01 00:00:00

  • Mycobacterium avium subspecies paratuberculosis and myelin basic protein specific epitopes are highly recognized by sera from patients with Neuromyelitis optica spectrum disorder.

    abstract::Epstein-Barr virus (EBV) is the main environmental agent associated to neuromyelitis optica spectrum disorder (NMOSD). Following to studies reporting an increased prevalence of antibodies against peptides derived from Mycobacterium avium subsp. paratuberculosis (MAP) homologous to EBV and human epitopes (MBP85-98, IRF...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2018.02.013

    authors: Bo M,Niegowska M,Arru G,Sechi E,Mariotto S,Mancinelli C,Farinazzo A,Alberti D,Gajofatto A,Ferrari S,Capra R,Monaco S,Sechi G,Sechi LA

    更新日期:2018-05-15 00:00:00

  • Opioid receptor-mediated suppression of humoral immune response in vivo and in vitro: involvement of kappa opioid receptors.

    abstract::The selective kappa opioid receptor agonist MR 2034 exerted pronounced suppression of plaque-forming cell (PFC) response following intraperitoneal (i.p.) administration in the rat. Pretreatment with preferential kappa and mu opioid receptor antagonists MR 2266 and naloxone, respectively, revealed that this effect was ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(94)00161-g

    authors: Radulović J,Miljević C,Djergović D,Vujić V,Antić J,von Hörsten S,Janković BD

    更新日期:1995-03-01 00:00:00

  • Psychopharmacological activity of immune complexes in rat brain is complement dependent.

    abstract::Sprague-Dawley male rats implanted with chronic indwelling cannulae at the perifornical hypothalamus eat excessively during the sixth hour following administration of exogenous immune-complexing reactants to the brain site. Rabbit anti-HSA was injected, followed in 30 min by a 20-fold excess of antigen. Anaphylatoxin ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(87)90065-8

    authors: Schupf N,Williams CA

    更新日期:1987-01-01 00:00:00

  • The involvement of neuroinflammation and necroptosis in the hippocampus during vascular dementia.

    abstract::The prevalence of vascular dementia is increasing at an alarming rate. The Confirmation of the clinical diagnosis of vascular dementia depends on post-mortem examination of the brain. In our study, we investigated the vascular disease and neuroinflammation during vascular dementia. Our results showed a β-amyloid depos...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2018.04.004

    authors: Belkhelfa M,Beder N,Mouhoub D,Amri M,Hayet R,Tighilt N,Bakheti S,Laimouche S,Azzouz D,Belhadj R,Touil-Boukoffa C

    更新日期:2018-07-15 00:00:00

  • Pattern recognition receptor mRNA expression and cytokine and granzyme levels in HIV infected individuals with neurotuberculosis.

    abstract::Neurotuberculosis is one of the commonest HIV-associated opportunistic infections (OI) of the CNS. Cross-talk between HIV, Mycobacterium tuberculosis and host immune responses may alter expression of pattern recognition receptors (PRRs), thereby affecting cytokine profiles and functional responses. We examined PRR mRN...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2018.01.015

    authors: Rao D,Vasanthapuram R,Satishchandra P,Desai A

    更新日期:2018-05-15 00:00:00

  • Production of interleukin-1 receptor antagonist by human glioblastoma cells in vitro and in vivo.

    abstract::We investigated the expression and production of the interleukin-1 receptor antagonist (IL-1ra) in three human glioblastoma cell lines (LN443, LN444, LN859). Reverse transcription-polymerase chain reaction (RT-PCR) demonstrated the expression of IL-1ra mRNA transcripts in the three cell lines. These three cell lines a...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(94)90045-0

    authors: Tada M,Diserens AC,Desbaillets I,Jaufeerally R,Hamou MF,de Tribolet N

    更新日期:1994-03-01 00:00:00

  • NGF modulates CGRP synthesis in human B-lymphocytes: a possible anti-inflammatory action of NGF?

    abstract::We investigated whether the sensory neuropeptide, calcitonin gene-related peptide (CGRP), could be synthesised by human lymphocytes. Our results indicate that in activated B-cells, there is a strong expression of CGRP gene transcripts, which is almost absent in resting cells. Since B-cells autocrinally produce NGF, th...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(01)00475-1

    authors: Bracci-Laudiero L,Aloe L,Buanne P,Finn A,Stenfors C,Vigneti E,Theodorsson E,Lundeberg T

    更新日期:2002-02-01 00:00:00

  • Nerve growth factor antibody exacerbates neuropathological signs of experimental allergic encephalomyelitis in adult lewis rats.

    abstract::In this study, experimental allergic encephalomyelitis (EAE) rats and rats exhibiting EAE expressing high circulating anti-nerve growth factor antibody were daily monitored for clinical signs and chronic relapses. Eighty-five days after EAE induction, blood, spinal cord and brain stem were used for histological examin...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(99)00272-6

    authors: Micera A,Properzi F,Triaca V,Aloe L

    更新日期:2000-05-01 00:00:00

  • Altered cytokine levels in the blood and cerebrospinal fluid of chronic pain patients.

    abstract::This study replicates and extends prior reports of abnormal cytokine levels in chronic pain patients and has correlated the alterations with pain severity. In addition, there appeared to be a need to directly assess cerebrospinal fluid (CSF) because previous findings on cytokine concentrations in peripheral circulatio...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2008.01.005

    authors: Backonja MM,Coe CL,Muller DA,Schell K

    更新日期:2008-03-01 00:00:00

  • Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat.

    abstract::Although it is generally accepted that pro-inflammatory cytokines produced by cells of the central nervous system play important roles in the communication between the central nervous system and the immune system during sepsis, it is not clear whether these cytokines are produced in the brain under subseptic condition...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(98)00193-3

    authors: Quan N,Stern EL,Whiteside MB,Herkenham M

    更新日期:1999-01-01 00:00:00

  • Restriction fragment length polymorphism analysis of HLA-DR- and DQ-linked alleles in multiple sclerosis in Spain.

    abstract::HLA-DR allele subtypes in multiple sclerosis (MS) individuals in Spain were determined by restriction fragment length polymorphism (RFLP) analysis. The well-established association of DRw15, DQw6, Dw2 alleles and MS susceptibility was confirmed. The strength of its association, however, was relatively weak in our MS p...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(92)90076-w

    authors: Clerici N,Fernández M

    更新日期:1992-12-01 00:00:00

  • Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in Guillain-Barré syndrome.

    abstract::Anti-galactocerebroside (GalC) antibodies are reported to be present in GBS patients with preceding Mycoplasma pneumoniae (MP) infection. We investigated the presence of anti-GalC reactivity in serum of a large group of GBS patients using ELISA and compared this with healthy controls and individuals with an uncomplica...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(02)00209-6

    authors: Ang CW,Tio-Gillen AP,Groen J,Herbrink P,Jacobs BC,Van Koningsveld R,Osterhaus AD,Van der Meché FG,van Doorn PA

    更新日期:2002-09-01 00:00:00

  • Risk factors of attacks in neuromyelitis optica spectrum disorders.

    abstract::Predisposing factors before the onset of neuromyelitis optica spectrum disorders (NMOSD) have not been systematically evaluated by now. We investigated the detailed pre-onset history in consecutive NMOSD patients. Thirteen of the enrolled 53 NMOSD patients (24.5%) had accompanying autoimmune diseases, such as Sjögren'...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2020.577236

    authors: Akaishi T,Takahashi T,Fujihara K,Misu T,Abe M,Ishii T,Aoki M,Nakashima I

    更新日期:2020-06-15 00:00:00

  • Invariant NKT cells in adrenoleukodystrophy patients and mice.

    abstract::X-linked adrenoleukodystrophy (X-ALD) is a severe neurological disease characterized by progressive demyelination within the CNS, adrenal insufficiency, and is associated with an accumulation of saturated very long chain fatty acids in plasma and tissues of patients. iNKT cells, a distinct lineage of T cells recognizi...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2010.09.003

    authors: Gautron AS,Giquel B,Beaudoin L,Autrusseau E,Speak A,Platt F,Kemp S,Pujol A,Aubourg P,Lehuen A

    更新日期:2010-12-15 00:00:00

  • Omega-3 polyunsaturated fatty acids ameliorate neuroinflammation and mitigate ischemic stroke damage through interactions with astrocytes and microglia.

    abstract::Omega-3 polyunsaturated fatty acids (PUFA n3) provide neuroprotection due to their anti-inflammatory and anti-apoptotic properties as well as their regulatory function on growth factors and neuronal plasticity. These qualities enable PUFA n3 to ameliorate stroke outcome and limit neuronal damage. Young adult male rats...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2014.11.007

    authors: Zendedel A,Habib P,Dang J,Lammerding L,Hoffmann S,Beyer C,Slowik A

    更新日期:2015-01-15 00:00:00

  • Serum BAFF expression in patients with myasthenia gravis.

    abstract::A B-cell activating factor of the tumor necrosis factor (TNF) family (BAFF) is an essential B-cell survival factor. Myasthenia gravis (MG) is one of the most typical antibody-mediated autoimmune disorders. To test whether serum BAFF levels are increased in MG patients, we compared the serum BAFF levels of 40 MG patien...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2008.05.010

    authors: Kim JY,Yang Y,Moon JS,Lee EY,So SH,Lee HS,Park KD,Choi YC

    更新日期:2008-08-13 00:00:00

  • Interferon-stimulated gene 60 (ISG60) constitutes a negative feedback loop in the downstream of TLR3 signaling in hCMEC/D3 cells.

    abstract::Brain capillary endothelial cells are the component of blood brain barrier, and the first line of defense against viruses invading into brain. We demonstrate that treatment of hCMEC/D3 cells, a human brain capillary endothelial cell line, with a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2018.08.016

    authors: Imaizumi T,Sassa N,Kawaguchi S,Matsumiya T,Yoshida H,Seya K,Shiratori T,Hirono K,Tanaka H

    更新日期:2018-11-15 00:00:00

  • Intravenous immunoglobulin reduces β amyloid and abnormal tau formation caused by herpes simplex virus type 1.

    abstract::Intravenous immunoglobulin (IVIG) treatment of Alzheimer's disease (AD) has been encouraging. Its mechanism of action might be via anti-β-amyloid (Aβ) antibodies which facilitate Aβ clearance. However, IVIG's benefits might result from its antiviral activity, particularly against herpes simplex virus type 1 (HSV1), a ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2013.01.005

    authors: Wozniak MA,Itzhaki RF

    更新日期:2013-04-15 00:00:00