当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Time course of penetration of xenogeneic IgG into the central nervous system of the neonatal rat: an immunohistochemical and radionuclide tracer study.

Time course of penetration of xenogeneic IgG into the central nervous system of the neonatal rat: an immunohistochemical and radionuclide tracer study.

Abstract：

:We investigated the penetration of rabbit IgG into the brain and spinal cord of newborn rat pups and compared them to mature rats using immunohistochemical and radionuclide techniques. Following intraperitoneal injection with rabbit IgG and perfusion fixation at various intervals, rabbit IgG was found to penetrate into the parenchyma of the neuraxis of neonatal rats and to establish much higher concentrations than was found in mature rats. Immunohistochemical studies revealed no evidence of significant extravasation of serum proteins from the vasculature. For any given survival interval studied, there was no significant difference in appearance and intensity of immunohistochemical staining or the amount of radiolabeled IgG measured between different areas of the brain and spinal cord. Electrophoresis of radioactive proteins extracted from the brains of neonatal rats injected with radiolabeled IgG confirmed that IgG penetrates into the brain parenchyma as the whole molecule. These results validate the use of systemically administered rabbit IgG for studies of brain development in neonatal rats. They also have implications for the pathogenesis of congenital central nervous system anomalies in which maternal autoimmune IgG may affect brain development after being transferred to the fetus or neonate.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Fabian RH,Hulsebosch CE

doi

10.1016/0165-5728(89)90116-1

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

183-9

issue

3

eissn

0165-5728

issn

1872-8421

pii

0165-5728(89)90116-1

journal_volume

24

pub_type

杂志文章

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