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Vaccination with a MHC class II peptide in Alum and inactive pertussis strongly ameliorates clinical MG in C57BL/6 mice.

Abstract：

:We have investigated the efficacy of immunization against peptides from predisposing MHC class II molecules in human-compatible adjuvants for ameliorating experimental autoimmune myasthenia gravis (EAMG). C57BL/6 mice were immunized three times with the peptide I-Abetab62-76 in Alum+killed pertussis organisms (PT) prior to two injections with tAChR. The treatment greatly reduced the occurrence and severity of clinical MG relative to controls that received saline/Alum+PT or none. It also reduced antibody and T-cell responses against tAChR. The results have important implications for the possible immunotherapy of MG by targeting disease-associated MHC.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Oshima M,Maruta T,Ohtani M,Deitiker PR,Mosier D,Atassi MZ

doi

10.1016/j.jneuroim.2005.09.015

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

8-16

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(05)00422-4

journal_volume

171

pub_type

杂志文章

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