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Anti-streptococcal, tubulin, and dopamine receptor 2 antibodies in children with PANDAS and Tourette syndrome: single-point and longitudinal assessments.

Abstract：

:Single-point-in-time ELISA optical densities for three putative antibodies identified in Sydenham's chorea, the streptococcal group A carbohydrate antigen, N-acetyl-beta-d-glucosamine, tubulin, and the dopamine 2 receptor, showed no differences in children with PANDAS (n=44) or Tourette syndrome (n=40) as compared to controls (n=24). Anti-tubulin and D2 receptor antibodies assessed in serial samples from 12 PANDAS subjects obtained prior to a documented exacerbation, during the exacerbation (with or without a temporally associated streptococcal infection), and following the exacerbation, showed no evidence of antibody levels correlating with a clinical exacerbation. These data do not support hypotheses suggesting an autoimmune hypothesis in either TS or PANDAS.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Morris-Berry CM,Pollard M,Gao S,Thompson C,Tourette Syndrome Study Group.,Singer HS

doi

10.1016/j.jneuroim.2013.09.010

subject

Has Abstract

pub_date

2013-11-15 00:00:00

pages

106-13

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(13)00252-X

journal_volume

264

pub_type

杂志文章

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