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Citrullinated myelin basic protein induces experimental autoimmune encephalomyelitis in Lewis rats through a diverse T cell repertoire.

Abstract：

:An increased proportion of citrullinated MBP (MBP-C8) occurs in the brains of multiple sclerosis (MS) patients. In this study, MBP-C8 from guinea pig (GP) brains was isolated and found encephalitogenic in Lewis rats upon immunization. An encephalitogenic T cell line selected with MBP-C8 preferentially reacted with MBP-C8 over unmodified MBP. This T cell line responded weakly to the dominant encephalitogenic epitope, GP-MBP peptide 70-88, and did not display restricted TCR beta-chain usage (such as Vbeta88.2). The distinctive features of MBP-C8 were also demonstrated by its ability to reinduce active EAE in 70% of rats which had recovered from unmodified MBP induced EAE. These findings raise the possibility that citrullinated MBP may elicit a different pathogenic T cell repertoire for the recurrent phases of inflammatory demyelination.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Cao L,Sun D,Whitaker JN

doi

10.1016/s0165-5728(98)00063-0

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

21-9

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(98)00063-0

journal_volume

88

pub_type

杂志文章

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