Abstract:
:Gelsolin is the fourth most abundant protein in the body and its depletion in the blood has been found in multiple sclerosis (MS) patients. How gelsolin affects the MS brain has not been studied. We found that while the secreted form of gelsolin (pGSN) decreased in the blood of experimental autoimmune encephalomyelitis (EAE) mice, pGSN concentration increased in the EAE brain. Recombinant human pGSN (rhp-GSN) decreased extracellular actin and myeloperoxidase activity in the brain, resulting in reduced disease activity and less severe clinical disease, suggesting that gelsolin could be a potential therapeutic target for MS.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Li-ChunHsieh K,Schob S,Zeller MW,Pulli B,Ali M,Wang C,Chiou TT,Tsang YM,Lee PS,Stossel TP,Chen JWdoi
10.1016/j.jneuroim.2015.08.006subject
Has Abstractpub_date
2015-10-15 00:00:00pages
36-42eissn
0165-5728issn
1872-8421pii
S0165-5728(15)30021-7journal_volume
287pub_type
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