Risk factors of attacks in neuromyelitis optica spectrum disorders.

Abstract:

:Predisposing factors before the onset of neuromyelitis optica spectrum disorders (NMOSD) have not been systematically evaluated by now. We investigated the detailed pre-onset history in consecutive NMOSD patients. Thirteen of the enrolled 53 NMOSD patients (24.5%) had accompanying autoimmune diseases, such as Sjögren's syndrome. History of malignancy was seen in 8 of the 53 patients (15.1%). Recent history of non-neurological clinical episodes, such as systemic allergic reaction, systemic infection, surgical operation, or traumatic injury, was seen in 23 of the 53 patients (43.4%). NMOSD patients are likely to have pre-onset history of other autoimmune diseases, malignancy, or recent non-neurological systemic conditions, which may predispose or trigger the onset of NMOSD.

journal_name

J Neuroimmunol

authors

Akaishi T,Takahashi T,Fujihara K,Misu T,Abe M,Ishii T,Aoki M,Nakashima I

doi

10.1016/j.jneuroim.2020.577236

subject

Has Abstract

pub_date

2020-06-15 00:00:00

pages

577236

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(20)30213-7

journal_volume

343

pub_type

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