Abstract:
:Predisposing factors before the onset of neuromyelitis optica spectrum disorders (NMOSD) have not been systematically evaluated by now. We investigated the detailed pre-onset history in consecutive NMOSD patients. Thirteen of the enrolled 53 NMOSD patients (24.5%) had accompanying autoimmune diseases, such as Sjögren's syndrome. History of malignancy was seen in 8 of the 53 patients (15.1%). Recent history of non-neurological clinical episodes, such as systemic allergic reaction, systemic infection, surgical operation, or traumatic injury, was seen in 23 of the 53 patients (43.4%). NMOSD patients are likely to have pre-onset history of other autoimmune diseases, malignancy, or recent non-neurological systemic conditions, which may predispose or trigger the onset of NMOSD.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Akaishi T,Takahashi T,Fujihara K,Misu T,Abe M,Ishii T,Aoki M,Nakashima Idoi
10.1016/j.jneuroim.2020.577236subject
Has Abstractpub_date
2020-06-15 00:00:00pages
577236eissn
0165-5728issn
1872-8421pii
S0165-5728(20)30213-7journal_volume
343pub_type
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