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Complementary strategies to elucidate T helper cell epitopes in myasthenia gravis.

Abstract：

:CD4(+) T cells specific for the acetylcholine receptor (AChR) are assumed to play an important role in pathogenesis of myasthenia gravis (MG). A large and diverse number of potential T cell epitopes have been reported for different experimental setups aiming at the identification of disease-relevant T cells in MG. Investigating the T cell response to the epsilon subunit of human AChR, we explore complementary in vitro and in vivo approaches (PBMC from MG patients and mice transgenic for HLA-DR3 and human CD4) to address the possibilities and limitations of different strategies for elucidating natural autoimmune T cell epitopes.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Jung C,Stoeckle C,Wiesmüller KH,Laub R,Emmrich F,Jung G,Melms A

doi

10.1016/j.jneuroim.2008.06.010

subject

Has Abstract

pub_date

2008-09-15 00:00:00

pages

41-9

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(08)00204-X

journal_volume

201-202

pub_type

杂志文章

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