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Sequential polymicrobial infections lead to CNS inflammatory disease: possible involvement of bystander activation in heterologous immunity.

Abstract：

:VV(PLP) is a recombinant vaccinia virus (VV) encoding myelin proteolipid protein (PLP) that has been used to investigate molecular mimicry and autoimmunity. Since virus infections can cause bystander activation, mice were first infected with VV(PLP), and later challenged with wild-type VV, lymphocytic choriomeningitis virus (LCMV), or murine cytomegalovirus (MCMV). Among the VV(PLP)-primed mice, only MCMV challenge induced significant Ki-67(+), CD3(+)T cell infiltration into the central nervous system (CNS) with a mild PLP antibody response. While MCMV alone caused no CNS disease, control VV-infected mice followed with MCMV developed mild CNS inflammation. Thus, heterologous virus infections can induce CNS pathology.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Tsunoda I,Libbey JE,Fujinami RS

doi

10.1016/j.jneuroim.2007.05.012

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

22-33

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(07)00160-9

journal_volume

188

pub_type

杂志文章

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