The change of PD1, PDL1 in experimental autoimmune encephalomyelitis treated by 1,25(OH)2D3.

abstract：:Matrix metalloproteinase-9 (MMP-9) has been reported to be expressed in various inflammatory disorders including human T cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-I-infected T-cells expressed high levels of MMP-9 via viral transactivator Tax mediated act...

journal_title：Journal of neuroimmunology

authors： Kodama D,Saito M,Matsumoto W,Sabouri AH,Izumo S,Arimura K,Usuku K,Bangham CR,Osame M

更新日期：2004-11-01 00:00:00

abstract：:To investigate immune mechanisms in the etiology of idiopathic sensory neuronopathy (ISN), we studied neurite outgrowth inhibition and antibody binding to neuronal tissue of serum from 4 patients with ISN. Rat dorsal root ganglion (DRG) cells were cultured in the presence of serum from ISN patients and controls. After...

journal_title：Journal of neuroimmunology

authors： van Dijk GW,Wokke JH,Notermans NC,van den Berg LH,Bär PR

更新日期：1997-04-01 00:00:00

abstract：:Mitoxantrone, a new antineoplastic anthracenedione drug, suppressed the development of experimental allergic encephalomyelitis (EAE) in rats when administered during the incubation period. One dose of mitoxantrone had a favorable effect on EAE even when withheld until after the onset of clinical signs. In a model of r...

journal_title：Journal of neuroimmunology

authors： Levine S,Saltzman A

更新日期：1986-12-01 00:00:00

abstract：:The skin response to myelin basic protein (MBP) was studied in chronic relapsing experimental allergic encephalomyelitis (EAE) using strain 13 guinea pigs. The delayed type skin response showed a monophasic curve; it gradually increased after immunization, reached maximum levels around 80 days post-immunization, and d...

journal_title：Journal of neuroimmunology

authors： Tabira T,Itoyama Y,Kuroiwa Y,Kubo C,Nagai Y

更新日期：1983-12-01 00:00:00

abstract：:We report here the results of a phase I trial of a T-cell receptor (TCR) V beta 6 CDR2 region peptide vaccine in 10 patients with multiple sclerosis who showed biased over-representations of V beta 6 mRNA among T-cells in their cerebrospinal fluids (CSF). One group of 5 patients was immunized twice during a four week ...

journal_title：Journal of neuroimmunology

authors： Gold DP,Smith RA,Golding AB,Morgan EE,Dafashy T,Nelson J,Smith L,Diveley J,Laxer JA,Richieri SP,Carlo DJ,Brostoff SW,Wilson DB

更新日期：1997-06-01 00:00:00

abstract：:Following hypoglossal nerve transection in adult rats, immunoreactivity for complement factor C3 and one of its degradation products C3d as well as C4d and immunoglobulin G (IgG) was observed in the ipsilateral hypoglossal nucleus. Double-labelling experiments indicated that these antigens were present in perineuronal...

journal_title：Journal of neuroimmunology

authors： Svensson M,Aldskogius H

更新日期：1992-09-01 00:00:00

abstract：:Immoderate immunoreaction of antigen-specific Th17 and Treg cell dysfunction play critical roles in the pathogenesis of multiple sclerosis. We examined Th17/Treg immune responses and the underlying mechanisms in response to metformin in C57BL/6 mice with experimental autoimmune encephalomyelitis (EAE). Metformin reduc...

journal_title：Journal of neuroimmunology

authors： Sun Y,Tian T,Gao J,Liu X,Hou H,Cao R,Li B,Quan M,Guo L

更新日期：2016-03-15 00:00:00

abstract：:Depression and chronic fatigue are frequently present in multiple sclerosis (MS); however, the prevalence rates have not been investigated in neuromyelitis optica (NMO). Thirty-nine consecutive NMO and 75 MS patients were compared using self-rating questionnaires for depressive states, daily activity, and fatigue, as ...

journal_title：Journal of neuroimmunology

authors： Akaishi T,Nakashima I,Misu T,Fujihara K,Aoki M

更新日期：2015-06-15 00:00:00

abstract：:Little is known about antibody production within the central nervous system, called intrathecal antibody production (ITAbP). Mice infected with Theiler's murine encephalomyocarditis virus (TMEV) develop an immune-mediated demyelinating disease(TMEV-IDD), characterized by progressive weakness associated with robust ITA...

journal_title：Journal of neuroimmunology

authors： Pachner AR,Brady J,Narayan K

更新日期：2007-10-01 00:00:00

abstract：:We studied the effect of acute (1 h) or chronic exposure (7 and 14 days) to delta9-tetrahydrocannabinol (delta9-THC) on immune parameters in male Swiss mice. One hour after a dose of 10 mg/kg s.c., the splenocyte proliferative response to ConA and NK activity were not inhibited, but there was a significant decrease in...

journal_title：Journal of neuroimmunology

authors： Massi P,Sacerdote P,Ponti W,Fuzio D,Manfredi B,Viganó D,Rubino T,Bardotti M,Parolaro D

更新日期：1998-12-01 00:00:00

abstract：:Emergent or elective surgical procedures may be complicated by sepsis, resulting in critical illness that can lead to organ failure and death. The opioid drug, morphine is widely used to alleviate pain in post-surgical patients; however, it is well documented that chronic treatment of mice with morphine affects the pr...

journal_title：Journal of neuroimmunology

authors： Roy S,Charboneau RG,Barke RA

更新日期：1999-03-01 00:00:00

abstract：:Mutations in the GBA gene are related to an increased risk of developing neurodegenerative diseases. The exact molecular mechanisms involved in the interaction between GBA and α-synuclein, a protein that has been associated with several neurological diseases, remain unsolved. Brain-derived neurotrophic factor (BDNF) i...

journal_title：Journal of neuroimmunology

authors： Vairo F,Sperb-Ludwig F,Wilke M,Michellin-Tirelli K,Netto C,Neto EC,Doederlein Schwartz IV

更新日期：2015-01-15 00:00:00

abstract：:Relative telomere length (TL) is regarded as a biomarker of biological age. Accelerated immune aging, as represented by TL reduction, has been demonstrated in autoimmune diseases, including multiple sclerosis (MS). However, it is still unresolved whether telomere shortening is the cause or the consequence of the patho...

journal_title：Journal of neuroimmunology

authors： Habib R,Ocklenburg S,Hoffjan S,Haghikia A,Epplen JT,Arning L

更新日期：2020-04-15 00:00:00

abstract：:Using congenic strains of mice susceptible (bcg(s)) or resistant (bcg(r)) to BCG, murine microglial cell lines, RR4.R (BCG-resistant) and RR8.S (BCG-susceptible), were established in vitro. Comparative studies revealed that, although phagocytic to a similar extent, RR4.R cells were more active than RR8.S cells in term...

journal_title：Journal of neuroimmunology

authors： Puliti M,Mazzolla R,Brozzetti A,Neglia R,Radzioch D,Bistoni F,Blasi E

更新日期：1999-11-01 00:00:00

abstract：:IFN-gamma (IFN-gamma) has been shown to activate astrocytes to acquire immune functions. In this study the effect of IFN-gamma on murine astrocytes was investigated via microarray analysis. The activating effect of IFN-gamma on the astrocyte transcriptome showed predominance toward pathways involved in adaptive immuni...

journal_title：Journal of neuroimmunology

authors： Halonen SK,Woods T,McInnerney K,Weiss LM

更新日期：2006-06-01 00:00:00

abstract：:Complement-dependent disruption of motor endplate is detected in anti-acetylcholine receptor (AChR) antibody-positive myasthenia gravis (MG). We measured serum AChR α1 subunit protein levels, which may be associated with neuromuscular damage, in 55 patients with MG (47 were seropositive and 8 were negative) and in 20 ...

journal_title：Journal of neuroimmunology

authors： Uzawa A,Ozawa Y,Yasuda M,Oda F,Kojima Y,Kawaguchi N,Kanai T,Himuro K,Kuwabara S

更新日期：2020-02-15 00:00:00

abstract：:Since multiple sclerosis (MS) is believed to be an immune-mediated disease, it follows that its therapies should be directed towards modulating the immune system. Current MS treatments, which include the use of exogenous steroids that are immunosuppressive, do not meet therapeutic objectives. delta 9-Tetrahydrocannabi...

journal_title：Journal of neuroimmunology

authors： Lyman WD,Sonett JR,Brosnan CF,Elkin R,Bornstein MB

更新日期：1989-06-01 00:00:00

abstract：:Functional studies of cerebrospinal fluid T lymphocytes during acute viral infections of the nervous system are rare. Recently, we had the opportunity to investigate the requirements for interferon-gamma (IFN-gamma) production of human in vivo activated (primary) cytotoxic T lymphocytes (CTL) generated during acute vi...

journal_title：Journal of neuroimmunology

authors： Martin R,Vallbracht A,Kreth HW

更新日期：1991-09-01 00:00:00

abstract：:Prion diseases are neurodegenerative disorders characterized by the accumulation of misfolded prion protein. In a previous study, we showed that neurotoxic prion peptide (PrP106-126) induced NALP3 inflammasome activation in mouse primary and immortalized microglia. In the present work, we examined the relevance of pha...

journal_title：Journal of neuroimmunology

authors： Shi F,Yang Y,Kouadir M,Fu Y,Yang L,Zhou X,Yin X,Zhao D

更新日期：2013-07-15 00:00:00

abstract：:Most patients with paraneoplastic encephalomyelitis/sensory neuronopathy PEM/SN have small-cell lung cancer (SCLC) and develop antibodies against neuronal-specific Hu proteins, which are abnormally expressed in the tumor. Anti-Hu reactivity is present in ~16% of SCLC patients without PEM/SN. Here we test the hypothesi...

journal_title：Journal of neuroimmunology

authors： Kazarian M,Calbo J,Proost N,Carpenter CL,Berns A,Laird-Offringa IA

更新日期：2009-12-10 00:00:00

abstract：:Lymphocytes isolated from Lewis rats immunised with protein antigen in adjuvant were stimulated to proliferate in vitro by splenic dendritic cells (DC) which had been pulsed with purified homologous myelin basic protein (MBP). By contrast, in parallel experiments, lymphocytes did not respond to ovalbumin unless the pr...

journal_title：Journal of neuroimmunology

authors： Gautam AM,Glynn P

更新日期：1989-04-01 00:00:00

abstract：:Allograft inflammatory factor-1 (AIF-1) is a 17-kDa-peptide identified in rat cardiac allografts undergoing chronic rejection and in activated microglial cells in inflammatory autoimune disease of the CNS. We have investigated the expression of AIF-1 in 18 autopsy cases of human focal cerebral infarction. AIF-1-positi...

journal_title：Journal of neuroimmunology

authors： Postler E,Rimner A,Beschorner R,Schluesener HJ,Meyermann R

更新日期：2000-08-01 00:00:00

abstract：:We used immunohistochemistry to assess the role of humoral and cellular factors in endoneurial microangiopathy and epineurial vasculitis in 15 nerve biopsies of patients with axonal neuropathy and monoclonal or mixed cryoglobulinemia (CG). Deposition of immunoglobulins and cytolytic complement was detected in endoneur...

journal_title：Journal of neuroimmunology

authors： Bonetti B,Invernizzi F,Rizzuto N,Bonazzi ML,Zanusso GL,Chinaglia G,Monaco S

更新日期：1997-03-01 00:00:00

abstract：:Unfractionated cytokines have been shown to induce in vitro proliferation of neonatal rat Schwann cells but the nature of the mitogen(s) is not known. A mixture of rabbit antibodies specific for recombinant interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) inhibited Schwann cell proliferation induced...

journal_title：Journal of neuroimmunology

authors： Lisak RP,Bealmear B

更新日期：1991-02-01 00:00:00

abstract：:Antibody responses to myelin antigens were analysed in 15 patients who developed acute neuroparalytic accidents (ANPA) during post-exposure rabies vaccination using a rabies vaccine prepared on brain tissues and in 30 individuals who were uneventfully vaccinated. High titers (> or = 100) of IgG and IgM antibodies to G...

journal_title：Journal of neuroimmunology

authors： Laouini D,Kennou MF,Khoufi S,Dellagi K

更新日期：1998-11-02 00:00:00

abstract：:We investigated the expression and production of the interleukin-1 receptor antagonist (IL-1ra) in three human glioblastoma cell lines (LN443, LN444, LN859). Reverse transcription-polymerase chain reaction (RT-PCR) demonstrated the expression of IL-1ra mRNA transcripts in the three cell lines. These three cell lines a...

journal_title：Journal of neuroimmunology

authors： Tada M,Diserens AC,Desbaillets I,Jaufeerally R,Hamou MF,de Tribolet N

更新日期：1994-03-01 00:00:00

abstract：:The prevalence of vascular dementia is increasing at an alarming rate. The Confirmation of the clinical diagnosis of vascular dementia depends on post-mortem examination of the brain. In our study, we investigated the vascular disease and neuroinflammation during vascular dementia. Our results showed a β-amyloid depos...

journal_title：Journal of neuroimmunology

authors： Belkhelfa M,Beder N,Mouhoub D,Amri M,Hayet R,Tighilt N,Bakheti S,Laimouche S,Azzouz D,Belhadj R,Touil-Boukoffa C

更新日期：2018-07-15 00:00:00

abstract：:Reactive oxygen intermediates (ROIs) are important mediators of a variety of pathological processes, including inflammation and ischemia/reperfusion injury. Cytokines and chemokines are detected at mRNA level in human and animal ischemic brains. This suggests that hypoxia/reoxygenation may induce cytokine production t...

journal_title：Journal of neuroimmunology

authors： Wang MJ,Huang HM,Hsieh SJ,Jeng KC,Kuo JS

更新日期：2001-01-01 00:00:00

abstract：:VCAM-1 is an adhesion molecule that is important to leukocyte movement across the blood-brain barrier and is involved in the formation of destructive CNS inflammatory lesions in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS). We examined VCAM-1 expression in the CNS of animals with passive...

journal_title：Journal of neuroimmunology

authors： Gimenez MA,Sim JE,Russell JH

更新日期：2004-06-01 00:00:00

abstract：:Acute experimental allergic neuritis (EAN) of Lewis rats was monitored by clinical and electrophysiological tests for 60 days. Sciatic nerve myelin proteins were analyzed by quantitative microgel electrophoresis and electroimmunoblotting at different clinical stages of the disease. The clinical severity of EAN and the...

journal_title：Journal of neuroimmunology

authors： Schott K,Jenner A,Wiethölter H,Schabet M,Stevens A

更新日期：1988-11-01 00:00:00