The involvement of neuroinflammation and necroptosis in the hippocampus during vascular dementia.

abstract：:Astrocytes provide crucial support for neurons and their impairment by viruses or their interactions with anti-viral or autoimmune responses could contribute to neurological disease. We have developed a transgenic mouse model to assess lymphocyte-astrocyte interactions. The major histocompatibility complex (MHC) class...

journal_title：Journal of neuroimmunology

authors： Rall GF,Mucke L,Nerenberg M,Oldstone MB

更新日期：1994-06-01 00:00:00

abstract：:In this study we have analysed the expression of mRNA encoding the m1-m5 mAChR subtypes in human blood mononuclear cells and subpopulations of lymphocytes using reverse transcriptase-polymerase chain reaction (RT-PCR) technique. Total RNA was extracted from human blood mononuclear cells. T cells, monocytes. EB virus t...

journal_title：Journal of neuroimmunology

authors： Hellström-Lindahl E,Nordberg A

更新日期：1996-08-01 00:00:00

abstract：PURPOSE:It will provide a reference for early detection, early diagnosis and early treatment of atypical primary Sjogren syndrome with neurological impairment as the first symptom. METHODS:Case report and Literature review. RESULTS:Here we report a 30-year-old woman diagnosed with trigeminal damage secondary to pSS w...

journal_title：Journal of neuroimmunology

authors： Yuan J,Gong L,Wu H,Chen Q,Wang J,Chen W,Wang X,Ren C

更新日期：2018-11-15 00:00:00

abstract：:We examined the role of Notch ligand Delta-like 1 (Delta1) in the development of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD). Blocking of Delta1 by anti-Delta1 monoclonal antibody (mAb) in the effector phase significantly suppressed the disease development of TMEV-IDD both ...

journal_title：Journal of neuroimmunology

authors： Tsugane S,Takizawa S,Kaneyama T,Ichikawa M,Yagita H,Kim BS,Koh CS

更新日期：2012-11-15 00:00:00

abstract：:TNF-related apoptosis-inducing ligand (TRAIL) is not only involved in cell death but also in other immunoregulatory mechanisms. So far, the regulation of the TRAIL pathway in physiologic and pathologic conditions remains unclear. Due to the implication in brain damage and the elevated expression in peripheral immune c...

journal_title：Journal of neuroimmunology

authors： Weber A,Wandinger KP,Mueller W,Aktas O,Wengert O,Grundström E,Ehrlich S,Windemuth C,Kuhlmann T,Wienker T,Brück W,Zipp F

更新日期：2004-04-01 00:00:00

abstract：:The myelin basic protein (MBP)-like material (MBPLM) in human urine is expressed in a cryptic epitope(s) present in MBP peptide 80-89 and absent or inaccessible in intact MBP. These features of urinary MBPLM have made it difficult to produce reagents for its further characterization. Using an immunogen of keyhole limp...

journal_title：Journal of neuroimmunology

authors： Whitaker JN,McKeehan A,Freeman DW

更新日期：1994-06-01 00:00:00

abstract：:In experimental autoimmune encephalomyelitis (EAE) and other neurodegenerative diseases, astrocytes play an important role in promoting or attenuating the inflammatory response through induction of different cytokines and growth factors. HuR plays a major role in regulating many of these factors by modulating RNA stab...

journal_title：Journal of neuroimmunology

authors： Wheeler C,Nabors LB,Barnum S,Yang X,Hu X,Schoeb TR,Chen D,Ardelt AA,King PH

更新日期：2012-05-15 00:00:00

abstract：:Several studies have proposed cerebral malaria (CM) as a CD4+ and CD8+ T lymphocyte-mediated disease. However, there are no data regarding the recruitment and/or persistence of these cells in the CNS following the phase of infection resolution. Glutamate-mediate excitotoxicity has also been implicated in CM. Blockade ...

journal_title：Journal of neuroimmunology

authors： de Miranda AS,Ferreira RN,Vieira ÉLM,Abreu LKS,Brant F,Vieira LB,Ribeiro FM,Machado FS,Rachid MA,Teixeira AL

更新日期：2019-05-15 00:00:00

abstract：:Nogo-A is a protein associated with central nervous system (CNS) myelin thought to impair regenerative responses and to suppress sprouting and plastic changes of synaptic terminals. In this study, we report that serum IgM autoantibodies to the recombinant large N-terminal inhibitory domain of Nogo-A are a frequent fin...

journal_title：Journal of neuroimmunology

authors： Reindl M,Khantane S,Ehling R,Schanda K,Lutterotti A,Brinkhoff C,Oertle T,Schwab ME,Deisenhammer F,Berger T,Bandtlow CE

更新日期：2003-12-01 00:00:00

abstract：:In the last decade, understanding of cancer initiation and progression has been given much attention with studies mainly focusing on genetic abnormalities. Importantly, cancer cells can influence their microenvironment and bi-directionally communicate with other systems such as the immune system. The nervous system pl...

journal_title：Journal of neuroimmunology

authors： Kuol N,Stojanovska L,Apostolopoulos V,Nurgali K

更新日期：2018-02-15 00:00:00

abstract：:Acute infusions of the formylated chemotactic peptide formyl-methionyl-leucyl-phenylalanine-lysine (FMLPL) or enkephalin analogue (Sandoz peptide) were made to the lateral cerebral ventricle of adult male rats to examine potential cellular responses within the central nervous system (CNS). Ependymal regions lining the...

journal_title：Journal of neuroimmunology

authors： Saland LC,Van Epps DE,Maez D,Gutierrez L,Samora A

更新日期：1988-06-01 00:00:00

abstract：:Employing immunohistochemical techniques and a panel of monoclonal antibodies that recognize rat cells of monocyte/macrophage lineage, we have demonstrated that cells labeled with these antibodies are widely distributed throughout the parenchyma of the rat brain. These cells have a remarkable microglial morphology and...

journal_title：Journal of neuroimmunology

authors： Honda H,Kimura H,Silvers WK,Rostami A

更新日期：1990-09-01 00:00:00

abstract：:Insulin-like growth factor-2 (IGF-2) present in media conditioned by non-activated and interferon gamma (IFN gamma)-treated microglia reduces galactocerebroside(+) (GalC) oligodendrocyte apoptosis in cultures derived both from the CG4 cell line and primary rat cortices. Microglia-derived IGF-2 also acts in each cultur...

journal_title：Journal of neuroimmunology

authors： Nicholas RS,Stevens S,Wing MG,Compston DA

更新日期：2002-03-01 00:00:00

abstract：:We previously reported that the CD4+ suppressor cells (Ts) that regulate recovery of Lewis rats from experimental autoimmune encephalomyelitis (EAE) produce transforming growth factor-beta (TGF-beta). We also reported that TGF-beta downregulates interferon-gamma (IFN-gamma), but not interleukin-2 (IL-2) production, by...

journal_title：Journal of neuroimmunology

authors： Stevens DB,Gould KE,Swanborg RH

更新日期：1994-04-01 00:00:00

abstract：:Multiple sclerosis (MS) patients were randomized, in a double blind design, and placed into either a vitamin D supplemented group or a placebo control group. As expected, serum 25-hydroxyvitamin D levels increased significantly following 6 month vitamin D supplementation (17+/-6 ng/ml at baseline to 28+/-8 ng/ml at 6 ...

journal_title：Journal of neuroimmunology

authors： Mahon BD,Gordon SA,Cruz J,Cosman F,Cantorna MT

更新日期：2003-01-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) has led to the identification of widespread brain abnormalities in multiple sclerosis (MS) that extend far beyond the classic white matter lesion. These findings have generated the idea that MS should be understood as a disease of the whole brain, not just the white matter. While it is...

journal_title：Journal of neuroimmunology

authors： Reich DS

更新日期：2017-03-15 00:00:00

abstract：:Fas (CD95) and Fas ligand (FasL, CD95L) have been implicated to be involved in the acute inflammatory response by attracting neutrophils and regulating their survival. Increased levels of soluble Fas and FasL are found in cerebrospinal fluid (CSF) samples of patients with bacterial meningitis but not in controls. Func...

journal_title：Journal of neuroimmunology

authors： Paul R,Angele B,Sporer B,Pfister HW,Koedel U

更新日期：2004-07-01 00:00:00

abstract：:Lymphocytic choriomeningitis virus (LCMV) induces a chronic, wasting syndrome when injected intracerebrally into H-2b mice homozygous for a beta 2-microglobulin (beta 2-m (-/-)) gene disruption. These mice have very few CD8+ T cells and express little class I MHC glycoprotein, though minimal levels of the H-2Db molecu...

journal_title：Journal of neuroimmunology

authors： Doherty PC,Hou S,Southern PJ

更新日期：1993-07-01 00:00:00

abstract：:Few histological studies have reported an increased of mast cells (MCs) in the brain of MS patients; we have therefore investigated whether this accumulation is associated with disease activity. We assessed a large series of post-mortem white matter samples from MS patients (n=59, 20 patients) and controls (n=28, 28 s...

journal_title：Journal of neuroimmunology

authors： Couturier N,Zappulla JP,Lauwers-Cances V,Uro-Coste E,Delisle MB,Clanet M,Montagne L,Van der Valk P,Bö L,Liblau RS

更新日期：2008-03-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) administration has been beneficially used in the treatment of several autoimmune disorders including myasthenia gravis (MG), although its mechanism of action is still not clear. To study the optimal conditions of IVIG treatment and delineate its mechanism of action we established a su...

journal_title：Journal of neuroimmunology

authors： Zhu KY,Feferman T,Maiti PK,Souroujon MC,Fuchs S

更新日期：2006-07-01 00:00:00

abstract：:In this study we evaluated the percentages of CD3(-)CD56(bright), CD3(-)CD56(dim), CD3(-)CD56(bright)perforin(+) and CD3(-)CD56(dim)perforin(+) Natural Killer (NK) cells in peripheral blood from untreated secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) patients and age and sex matched h...

journal_title：Journal of neuroimmunology

authors： Plantone D,Marti A,Frisullo G,Iorio R,Damato V,Nociti V,Patanella AK,Bianco A,Mirabella M,Batocchi AP

更新日期：2013-12-15 00:00:00

abstract：:We studied the effects of combination treatment with an anti-inflammatory agent, interferon (IFN)-beta, and a putative neuroprotective agent, an estrogen receptor (ER)-beta ligand, during EAE. Combination treatment significantly attenuated EAE disease severity, preserved axonal densities in spinal cord, and reduced CN...

journal_title：Journal of neuroimmunology

authors： Du S,Sandoval F,Trinh P,Voskuhl RR

更新日期：2010-02-26 00:00:00

abstract：:Alpha-melanocyte-stimulating hormone (alpha-MSH) is an endogenous neuroimmunomodulatory peptide that can inhibit a broad range of inflammatory mediators known to be involved in the pathophysiology of bacterial meningitis. We evaluated the effect of alpha-MSH in a rat model of pneumococcal meningitis. Rats were intraci...

journal_title：Journal of neuroimmunology

authors： Kastenbauer S,Koedel U,Brzoska T,Luger TA,Pfister HW

更新日期：2001-05-01 00:00:00

abstract：:The 802-2 peptide, designed from the conserved D1-CC' loop region of human CD4, can disrupt CD4(+) T cell activation in both human and murine systems. Here, 802-2 was investigated for efficacy in acute murine experimental allergic encephalomyelitis (EAE) models, and was found to significantly reduce the severity of di...

journal_title：Journal of neuroimmunology

authors： Edling AE,Choksi S,Huang Z,Korngold R

更新日期：2001-01-01 00:00:00

abstract：:Lewis (LEW) and DA rats are highly susceptible to experimental autoimmune encephalomyelitis (EAE) induced with guinea pig myelin basic protein (MBP), but respond to different epitopes. The dominant epitope for LEW rats is MBP73-86, and disease is mediated primarily by Vbeta8.2 Th1 cells. DA rats lack conventional Vbet...

journal_title：Journal of neuroimmunology

authors： Lenz DC,Wolf NA,Swanborg RH

更新日期：2001-03-01 00:00:00

abstract：:Prion diseases are neurodegenerative disorders characterized by the accumulation of misfolded prion protein. In a previous study, we showed that neurotoxic prion peptide (PrP106-126) induced NALP3 inflammasome activation in mouse primary and immortalized microglia. In the present work, we examined the relevance of pha...

journal_title：Journal of neuroimmunology

authors： Shi F,Yang Y,Kouadir M,Fu Y,Yang L,Zhou X,Yin X,Zhao D

更新日期：2013-07-15 00:00:00

abstract：:Multiple sclerosis (MS) is a putative autoimmune disease of the central nervous system (CNS) in which autoreactive immune cells recognizing myelin antigens lead to demyelination and axonal injury. Mechanisms relevant to the pathogenesis of MS have not been fully elucidated, particularly those underlying initiation of ...

journal_title：Journal of neuroimmunology

authors： Selmaj I,Mycko MP,Raine CS,Selmaj KW

更新日期：2017-05-15 00:00:00

abstract：:Cerebrospinal fluid (CSF) was taken from guinea pigs in various stages of chronic relapsing experimental allergic encephalomyelitis (CR-EAE). The leucocytes in CSF samples were counted and subjected to immunocytochemical analysis using monoclonal antibodies selectively recognising guinea pig T cells, macrophages or Ia...

journal_title：Journal of neuroimmunology

authors： Suckling AJ,Baron PW,Mauer U,Burger R,Rumsby MG

更新日期：1986-03-01 00:00:00

abstract：:Recent evidence supports the possible involvement of myelin basic protein (BP) as one of the target autoantigens in multiple sclerosis (MS), including elevated frequencies of MS blood and cerebrospinal fluid (CSF) T cells, and the presence in MS plaque tissue of V beta gene sequences and CDR3 motifs characteristic of ...

journal_title：Journal of neuroimmunology

authors： Satyanarayana K,Chou YK,Bourdette D,Whitham R,Hashim GA,Offner H,Vandenbark AA

更新日期：1993-04-01 00:00:00

abstract：:We investigated T cell epitopes of guinea pig myelin basic protein (MBP) that induce experimental autoimmune encephalomyelitis (EAE) in DA rats, using synthetic peptides that correspond to regions of the guinea pig MBP molecule that are homologous to rat MBP. Four peptides were encephalitogenic when tested in DA rats....

journal_title：Journal of neuroimmunology

authors： Stepaniak JA,Wolf NA,Sun D,Swanborg RH

更新日期：1997-09-01 00:00:00