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Quantitative analysis of the cellular constituents of the cerebrospinal fluid in chronic relapsing experimental allergic encephalomyelitis.

Abstract：

:Cerebrospinal fluid (CSF) was taken from guinea pigs in various stages of chronic relapsing experimental allergic encephalomyelitis (CR-EAE). The leucocytes in CSF samples were counted and subjected to immunocytochemical analysis using monoclonal antibodies selectively recognising guinea pig T cells, macrophages or Ia antigens. The results showed that total leucocyte numbers and the proportion of macrophages in CSF were elevated in the acute phase of CR-EAE but samples of CSF from animals in early relapse did not show a significant elevation in leucocyte count or macrophage content. In addition the level of T cell activation was higher in CSF than in peripheral blood during disease and was highest in the acute and immediately post-acute phases of the CR-EAE.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Suckling AJ,Baron PW,Mauer U,Burger R,Rumsby MG

doi

10.1016/0165-5728(86)90075-5

subject

Has Abstract

pub_date

1986-03-01 00:00:00

pages

57-66

issue

1

eissn

0165-5728

issn

1872-8421

pii

0165-5728(86)90075-5

journal_volume

11

pub_type

杂志文章

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