Abstract:
:The inflammatory reaction in autoimmune polymyositis and rejection of transplanted myoblasts is characterized by mononuclear cell infiltration. In other settings monocytes are locally recruited by an IL-6-induced IL-8-to-MCP-1 switch. IL-6, upon binding to soluble gp80 (sIL-6R), can interact with membrane-bound ubiquitously expressed gp130 and activate virtually all cells (transsignaling). We found that human myoblasts could use transsignaling to produce IL-6, MCP-1 and ICAM-1; the addition of sIL-6R, binding to IL-1beta-induced IL-6, greatly increases IL-6 production. These in vitro data support the hypothesis that locally secreted IL-6 can target monocyte chemotaxis and leukocytes trafficking through an IL-6, MCP-1 and ICAM-1 modulation.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Marino M,Scuderi F,Provenzano C,Scheller J,Rose-John S,Bartoccioni Edoi
10.1016/j.jneuroim.2008.02.005subject
Has Abstractpub_date
2008-05-30 00:00:00pages
41-8issue
1-2eissn
0165-5728issn
1872-8421pii
S0165-5728(08)00047-7journal_volume
196pub_type
杂志文章abstract::Serum levels of immunoreactive interleukin-2 (IL-2) were determined at monthly intervals from a group of placebo- and drug-treated chronic progressive multiple sclerosis patients before and during a cyclosporine A therapeutic trial. Significantly elevated levels of the lymphokine in active patients confirmed earlier s...
journal_title:Journal of neuroimmunology
pub_type: 临床试验,杂志文章
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abstract::Narcolepsy was first shown to be tightly associated with HLA-DR2 and DQ1 in 1983, suggesting a possible autoimmune mechanism. Early investigations failed to demonstrate this hypothesis, postulating that HLA-DR2 was only a linkage marker for another, unknown narcolepsy-causing gene. The autoimmune hypothesis is now bei...
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abstract::Little is known about the involvement of cytokines in the pathogenesis of primary progressive (PP) multiple sclerosis (MS). We evaluated in this cross-sectional study whether IL-18, IL-12p35, IL-12p40, TNF-alpha, IFN-gamma, IL-10, IL-4, TGF-beta, IL-12Rbeta1, and IL-12Rbeta2 mRNA expression in unstimulated white blood...
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abstract::Cells that produce interleukin-6 (IL-6) require the presence of signaling molecules since this cytokine is not normally constitutively expressed. It is now established that astrocytes produce IL-6; however, the precise inducing molecules and the kinetics of their action have not yet been clearly identified. In the cur...
journal_title:Journal of neuroimmunology
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abstract::Resistance to experimental allergic encephalomyelitis (EAE) induction by homogenized myelin (MSCH) in complete Freund's adjuvant (CFA) and pertussigen (P) in SJL mice was seen 1 week after intravenous injection of PLP 139-151 coupled to spleen cells (PLP-ECDI-SP). Although this resistance could be transferred by splee...
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更新日期:2010-04-15 00:00:00
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1997-04-01 00:00:00
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
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pub_type: 杂志文章,多中心研究
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2006.02.015
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:1990-12-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:1999-08-03 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2014.10.006
更新日期:2014-12-15 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2015-01-15 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2011-03-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2016-12-15 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2014.06.006
更新日期:2014-08-15 00:00:00