Autoantibodies against pituitary peptides in sera from patients with multiple sclerosis.

abstract：:Emerging autoimmunity (epitope-spreading) generated as a consequence of myelin damage is suggested to underlie the relapses in multiple sclerosis (MS). Myelin oligodendrocyte glycoprotein (MOG 8-21) induces relapsing EAE in ABH mice characterized by broadening of the autoimmune reportoire. Despite epitope spreading to...

journal_title：Journal of neuroimmunology

authors： Smith PA,Morris-Downes M,Heijmans N,Pryce G,Arter E,O'Neill JK,'t Hart B,Baker D,Amor S

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:Psychological stress has been implicated in the pathophysiology of both inflammatory and functional gastrointestinal (GI) diseases. The goal of this study was to address neuroendocrine modulation of cytokine production by peripheral blood cells in GI diseases. METHODS:We analyzed the in vitro effects of the ...

journal_title：Journal of neuroimmunology

authors： Lucas A,Cobelens PM,Kavelaars A,Heijnen CJ,Holtmann G,Haag S,Gerken G,Langhorst J,Dobos GJ,Schedlowski M,Elsenbruch S

更新日期：2007-01-01 00:00:00

abstract：:Neurocysticercosis (NC) presents two broad clinical entities: extraparenchymal (EP-NC) and parenchymal (P-NC). Using ELISA methodology, we demonstrate autoantibodies to tubulin and the Major oligodendrocyte glycoprotein (MOG) in the CSF of most, but not all, EP-NC samples. Levels of these autoantibodies were considera...

journal_title：Journal of neuroimmunology

authors： Parkhouse RME,Sciutto E,Hernández M,Cortez MM,Carpio A,Fleury A

更新日期：2020-12-15 00:00:00

abstract：:We evaluated the association of the platelet-activating factor receptor (PAFR) gene polymorphism (A224D) with the susceptibility and severity of multiple sclerosis (MS) in a Japanese population. DNA was collected from 162 Japanese patients with clinically definite 'conventional' MS (MS) and 245 healthy controls. The m...

journal_title：Journal of neuroimmunology

authors： Osoegawa M,Miyagishi R,Ochi H,Nakamura I,Niino M,Kikuchi S,Murai H,Fukazawa T,Minohara M,Tashiro K,Kira J

更新日期：2005-04-01 00:00:00

abstract：:Autotaxin (ATX) is an enzyme producing lysophosphatidic acid (LPA) from lysophosphatidyl choline (LPC) and it is up-regulated in inflammatory conditions such as various cancers, arthritis and multiple sclerosis (MS). Numerous studies have shown that the LPA signaling gives rise to angiogenesis, mitosis, cell prolifera...

journal_title：Journal of neuroimmunology

authors： Zahednasab H,Balood M,Harirchian MH,Mesbah-Namin SA,Rahimian N,Siroos B

更新日期：2014-08-15 00:00:00

abstract：:The presence of muscarinic acetylcholine receptors on lymphocytes has been demonstrated by radioligand binding experiments. Although the specific subtype(s) of muscarinic acetylcholine receptors expressed in lymphocytes is still unknown, some reports suggest the presence of the m2 subtype. In this study we analyzed th...

journal_title：Journal of neuroimmunology

authors： Costa P,Castoldi AF,Traver DJ,Costa LG

更新日期：1994-01-01 00:00:00

abstract：:The purposes of this study were to determine plasma and intestinal epinephrine (E) and norepinephrine (NE) concentrations in mice after exercise stress and, the effect of intravenous injection of E and NE (at concentrations during exercise) on viability of intestinal lymphocytes (IL). Exhaustive exercise significantly...

journal_title：Journal of neuroimmunology

authors： Marra S,Burnett M,Hoffman-Goetz L

更新日期：2005-01-01 00:00:00

abstract：:Within the immunosuppressive ocular microenvironment, there are constitutively present the immunomodulating neuropeptides alpha-melanocyte stimulating hormone (α-MSH) and neuropeptide Y (NPY) that promote suppressor functionality in macrophages. In this study, we examined the possibility that α-MSH and NPY modulate ph...

journal_title：Journal of neuroimmunology

authors： Phan TA,Taylor AW

更新日期：2013-07-15 00:00:00

abstract：:Interleukin-6 (IL-6) can activate gastrointestinal submucosal neurons, with associated implications for motility and secretory function. Patients with irritable bowel syndrome (IBS) have elevated levels of circulating IL-6. Colons from the Wistar Kyoto (WKY) rat model of IBS secrete more IL-6 (12.84 pg/ml) than contro...

journal_title：Journal of neuroimmunology

authors： O'Malley D,Dinan TG,Cryan JF

更新日期：2011-06-01 00:00:00

abstract：:Myasthenia gravis (MG) is an autoimmune disease in which autoantibodies, most commonly directed against the acetylcholine receptor (AChR), impair neuromuscular transmission and cause muscle weakness. In this study, we utilized two-dimensional difference in-gel electrophoresis (2D-DIGE) to analyze the muscle's proteomi...

journal_title：Journal of neuroimmunology

authors： Gomez AM,Vanheel A,Losen M,Molenaar PC,De Baets MH,Noben JP,Hellings N,Martinez-Martinez P

更新日期：2013-08-15 00:00:00

abstract：:We found that rejuvenation of the recipient immunity by inoculation of young CD4(+) T cells or a fetal thymus graft led to down regulation of the interleukin 1 receptor type II (IL-1R2) gene in CD4(+) T cells and reduced age-related hearing loss and degeneration of the spiral ganglion in SAMP1 mice, a murine model of ...

journal_title：Journal of neuroimmunology

authors： Iwai H,Inaba M

更新日期：2012-09-15 00:00:00

abstract：:We analyzed the characteristics of 29 Guillain-Barré syndrome (GBS) patients with IgM anti-GalNAc-GD1a antibodies. Fourteen of them had had an antecedent cytomegalovirus infection (CMV group) and 12 gastrointestinal infection (G-I group). Most of the G-I group patients (nine of 12) were subsequent to Campylobacter jej...

journal_title：Journal of neuroimmunology

authors： Kaida K,Kusunoki S,Kamakura K,Motoyoshi K,Kanazawa I

更新日期：2001-02-15 00:00:00

abstract：:Endogenous hypothalamic pro-inflammatory cytokines modulate the hypothalamic-pituitary-adrenal (HPA) axis responses. To investigate whether hypothalamic IL-1beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) are associated with differential inflammatory susceptibilities between Lewis (LEW/N) and Fischer (F344/N) ...

journal_title：Journal of neuroimmunology

authors： Wei R,Listwak SJ,Sternberg EM

更新日期：2003-02-01 00:00:00

abstract：:Virus may be recovered from various areas of the central nervous system (CNS) of mice for as long as 11 days after inoculation of herpes simplex virus type 1 (HSV-1) into the lip. The probability of isolation from any particular region of the CNS seems to be a function of the distance of that area from the root-entry ...

journal_title：Journal of neuroimmunology

authors： Kastrukoff L,Hamada T,Schumacher U,Long C,Doherty PC,Koprowski H

更新日期：1982-06-01 00:00:00

abstract：:Depending on the duration and severity, psychological tension and physical stress can enhance or suppress the immune system in both humans and animals. Although it has been established that chronic stress exerts a significant suppressive effect on immune function, the mechanisms by which affects immune responses remai...

journal_title：Journal of neuroimmunology

authors： Zhang H,Caudle Y,Wheeler C,Zhou Y,Stuart C,Yao B,Yin D

更新日期：2018-01-15 00:00:00

abstract：:Loss-of-function mutations of DAP12 and TREM2 cause a recessively inherited disease PLOSL, manifesting in brain white matter. The genes of the DAP12-TREM2 signaling receptor are located on 19q13.12 and 6p21.1, to which linkage has been observed also in families affected by another immune-mediated demyelinating disease...

journal_title：Journal of neuroimmunology

authors： Sulonen AM,Kallio SP,Ellonen P,Suvela M,Elovaara I,Koivisto K,Pirttilä T,Reunanen M,Tienari PJ,Palotie A,Peltonen L,Saarela J

更新日期：2009-01-03 00:00:00

abstract：:This study was aimed at (i) comparison of the usefulness of serum protein oxidation parameters for assessment of oxidative stress (OS) in multiple sclerosis (MS), and (ii) comparison of OS in MS patients subject to various therapies. Elevated glycophore level was noted in relapsing-remitting (RRMS) patients without tr...

journal_title：Journal of neuroimmunology

authors： Sadowska-Bartosz I,Adamczyk-Sowa M,Gajewska A,Bartosz G

更新日期：2014-01-15 00:00:00

abstract：:The hormone 1 alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) has immune modulatory activities in vitro and in vivo, and can prevent or delay the onset of experimental or spontaneous autoimmune diseases. At therapeutical doses, however, hypercalcemic side effects are found. The present experiments examined the effects of ...

journal_title：Journal of neuroimmunology

authors： Branisteanu DD,Waer M,Sobis H,Marcelis S,Vandeputte M,Bouillon R

更新日期：1995-09-01 00:00:00

abstract：:We report human leukocyte antigen (HLA) class I expression in 5-17% and class II in 0-9% of first trimester human spinal cord cells. After 8 days in culture with gamma-interferon, >87% of the spinal cord cells expressed HLA class II. However, mixed cultures of adult human peripheral lymphocytes and immature human spin...

journal_title：Journal of neuroimmunology

authors： Akesson E,Markling L,Kjaeldgaard A,Falci S,Ringdén O

更新日期：2000-11-01 00:00:00

abstract：:Childhood opsoclonus-myoclonus syndrome (OMS) occurs idiopathic or, in association with a neuroblastoma, as a paraneoplastic syndrome. Since autoantibodies were identified in some patients, an autoimmune pathogenesis has been suspected. While the newly discovered B-cell activating factors BAFF and APRIL are involved i...

journal_title：Journal of neuroimmunology

authors： Fühlhuber V,Bick S,Kirsten A,Hahn A,Gerriets T,Tschernatsch M,Kaps M,Preissner KT,Blaes F,Altenkämper S

更新日期：2009-05-29 00:00:00

abstract：:NFS/N mice infected with neurotropic Cas-Br-M murine leukemia virus (MuLV) at 21 days of age were resistant to neurologic disease and demonstrated MuLV-specific cytotoxic T lymphocyte (CTL) activity in spleen cells after in vitro stimulation. NFS/N mice infected with Cas-Br-M MuLV at 2 days of age failed to generate a...

journal_title：Journal of neuroimmunology

authors： Robbins DS,Hoffman PM

更新日期：1991-01-01 00:00:00

abstract：:Peptide p259-271 of the human acetylcholine receptor alpha-subunit, preferentially stimulates T cells of patients with myasthenia gravis (MG) and is an immunodominant epitope for T cells of BALB/c mice. A p259-271 specific T cell line of BALB/c origin was established and was shown to induce experimental MG in naive mi...

journal_title：Journal of neuroimmunology

authors： Katz-Levy Y,Dayan M,Wirguin I,Fridkin M,Sela M,Mozes E

更新日期：1998-05-01 00:00:00

abstract：:Lewis rats were treated from day of birth with a rabbit anti-rat IgM antiserum. As adults these animals were found to have no detectable serum IgM and greatly reduced levels of IgG. They failed to respond to the B-cell mitogen LPS, or to make antibodies to sheep red blood cells (SRBC) or myelin basic protein (BP). The...

journal_title：Journal of neuroimmunology

authors： Willenborg DO,Prowse SJ

更新日期：1983-10-01 00:00:00

abstract：:The effectiveness of T cell vaccination was analyzed in experimental autoimmune neuritis (EAN) that can be induced by immunization with bovine P2 protein or a peptide representing the amino acids 53-78 of P2 (P2 53-78). Lewis rats were vaccinated with glutaraldehyde-fixed lymph node cells which had been primed in vivo...

journal_title：Journal of neuroimmunology

authors： Jung S,Schluesener HJ,Toyka K,Hartung HP

更新日期：1991-12-01 00:00:00

abstract：:To investigate T cell responses in subacute sclerosing panencephalitis (SSPE), we analyzed proliferation and cytokine secretion of cells from 35 patients and 42 healthy controls (HC) in response to central nervous system (CNS) antigens. The proliferation in response to myelin basic protein (MBP), myelin oligodendrocyt...

journal_title：Journal of neuroimmunology

authors： Yentür SP,Gürses C,Demirbilek V,Yilmaz G,Onal AE,Yapici Z,Yalçinkaya C,Cokar O,Gökyiğit A,Saruhan-Direskeneli G

更新日期：2005-12-30 00:00:00

abstract：:Aging is associated with increased glial responsiveness that may enhance the brain's susceptibility to injury and disease. To determine whether unique age-related molecular responses occur in brain injury, we assessed mRNA levels of representative central nervous system (CNS) inflammation-related molecules in young (3...

journal_title：Journal of neuroimmunology

authors： Kyrkanides S,O'Banion MK,Whiteley PE,Daeschner JC,Olschowka JA

更新日期：2001-10-01 00:00:00

abstract：:We analyzed the relationship between the expression of interferon (IFN)-gamma and HTLV-I p19 antigen and activation of p38 mitogen-activated protein kinase (p38 MAPK) in two HTLV-I-infected T cell lines derived from two patients (HCT-1 and HCT-4) with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)...

journal_title：Journal of neuroimmunology

authors： Fukushima N,Nishiura Y,Nakamura T,Yamada Y,Kohno S,Eguchi K

更新日期：2005-02-01 00:00:00

abstract：:Myelination in the central nervous system requires an accurate interplay between oligodendrocyte precursor cells (OPC) and axons. By as yet not fully understood mechanisms, OPC proliferate, migrate to the axon to be myelinated and finally differentiate into mature oligodendrocytes. The recent finding that OPC express ...

journal_title：Journal of neuroimmunology

authors： Maysami S,Nguyen D,Zobel F,Heine S,Höpfner M,Stangel M

更新日期：2006-09-01 00:00:00

abstract：:Methadone is known to exert modulatory effects on the immune system. We investigated the potential effects of methadone on infiltration of inflammatory cells into the spinal cord, as well as the proliferative and cytokine responses of T cells in MOG(35-55)-induced experimental autoimmune encephalomyelitis in mice. Met...

journal_title：Journal of neuroimmunology

authors： Kafami L,Etesami I,Felfeli M,Enayati N,Ghiaghi R,Aminian A,Dehpour A

更新日期：2013-02-15 00:00:00

abstract：:This study investigated whether anti-CD40 Ab and 8-oxo-dG attenuate mast cell migration and EAE development. Anti-CD40 Ab and 8-oxo-dG reduced EAE scores, mast cell numbers, expression of adhesion molecules, OX40L and Act1, levels of TNF-α, LTs, expression of cytokines, and co-localization of Treg cells and mast cells...

journal_title：Journal of neuroimmunology

authors： Hong GU,Kim NG,Jeoung D,Ro JY

更新日期：2013-07-15 00:00:00