当前位置： SCI文献检索 > JOURNAL OF NEUROIMMUNOLOGY期刊下所有文献 > Fetal thymus graft prevents age-related hearing loss and up regulation of the IL-1 receptor type II gene in CD4(+) T cells.

Fetal thymus graft prevents age-related hearing loss and up regulation of the IL-1 receptor type II gene in CD4(+) T cells.

Abstract：

:We found that rejuvenation of the recipient immunity by inoculation of young CD4(+) T cells or a fetal thymus graft led to down regulation of the interleukin 1 receptor type II (IL-1R2) gene in CD4(+) T cells and reduced age-related hearing loss and degeneration of the spiral ganglion in SAMP1 mice, a murine model of human senescence. Our studies on the relationship between age-related systemic immune dysfunctions and neurodegeneration mechanisms open up new avenues of treatment of neurosenescence, including presbycusis, for which there is no effective therapy.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Iwai H,Inaba M

doi

10.1016/j.jneuroim.2012.05.007

subject

Has Abstract

pub_date

2012-09-15 00:00:00

pages

1-8

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(12)00161-0

journal_volume

250

pub_type

杂志文章

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