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Fingolimod and related compounds in a spontaneous autoimmune polyneuropathy.

Abstract：

:We investigated potential therapeutic effects of sphingosine-1-phosphate (S1P) receptor modulators FTY720 (fingolimod) and selective S1P1 agonist SEW2871 on a spontaneous autoimmune polyneuropathy (SAP) when given orally at 7 mo (anticipated disease onset) for 4 weeks. Clinical severity, electrophysiologic and histological findings were ameliorated in mice treated with 1 mg/kg of FTY720. Subsequent studies showed that SEW2871 was also effective in halting the progression of SAP, which was accompanied by decreased proliferative and cytokine responses to myelin protein zero (P0), and an increase in regulatory T cells. We conclude that S1P receptor modulators may play a therapeutic role in autoimmune neuropathies.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Kim HJ,Jung CG,Dukala D,Bae H,Kakazu R,Wollmann R,Soliven B

doi

10.1016/j.jneuroim.2009.07.006

subject

Has Abstract

pub_date

2009-09-29 00:00:00

pages

93-100

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(09)00268-9

journal_volume

214

pub_type

杂志文章

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