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Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions.

Abstract：

:Matrix metalloproteinases (MMPs) are proteases involved in extracellular matrix (ECM) remodeling, leukocyte infiltration into lesions and myelin degradation in the central nervous system (CNS) disease multiple sclerosis (MS). We have investigated whether MMP-12 (macrophage metalloelastase) is expressed in MS lesions at various stages. In control patient tissue and (p)reactive MS lesions, only occasional microglial and astrocyte staining was detected. In contrast, in active demyelinating lesions, phagocytic macrophages were MMP-12 positive. A lower proportion of phagocytes was positive for MMP-12 in chronic active demyelinating lesions and inactive lesions. This suggests a role for MMP-12 during demyelination in MS.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Vos CM,van Haastert ES,de Groot CJ,van der Valk P,de Vries HE

doi

10.1016/s0165-5728(03)00036-5

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

106-14

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572803000365

journal_volume

138

pub_type

杂志文章

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