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Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFalpha-induced resistance to IGF-I in myoblasts.

Abstract：

:IL-10 is an anti-inflammatory cytokine that suppresses synthesis of proinflammatory cytokines and their receptors. Here we tested the possibility that TNFalpha-induced hormone resistance in myoblasts might be overcome by IL-10. We found that IL-10 restores myogenesis by suppressing the ability of exogenous TNFalpha to inhibit IGF-I-induced myogenin. This protection occurs without decreasing global activity of TNF receptors since IL-10 does not impair TNFalpha-induced IL-6 synthesis or ERK1/2 phosphorylation. Instead, IL-10 acts to prevent TNFalpha-induced phosphorylation of JNK. These findings demonstrate that IL-10 serves a previously unrecognized protective role in muscle progenitors by overcoming TNFalpha-induced resistance to IGF-I.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Strle K,McCusker RH,Tran L,King A,Johnson RW,Freund GG,Dantzer R,Kelley KW

doi

10.1016/j.jneuroim.2007.05.003

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

48-55

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(07)00169-5

journal_volume

188

pub_type

杂志文章

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