Abstract:
:This study investigates the role of beta-adrenergic receptors in the immunomodulatory effects of a conditioned aversive stimulus (CS). A CS is an environmental event that is not inherently aversive, but acquires aversive properties through pairings with a stimulus such as electric shock. This study evaluated the effects of administration of the beta 1-receptor selective antagonist atenolol, and the beta 2-receptor antagonist ICI 118,551 on conditioned immune alterations. Administration of either antagonist prior to presentation of the CS resulted in a dose-dependent attenuation of the CS-induced suppression of splenic T-cell proliferative response to concanavalin A, phytohemagglutinin, and the combination of ionomycin/phorbol-myristate-acetate. Furthermore, both antagonists dose-dependently attenuated the CS-induced suppression of gamma-interferon production by concanavalin-A (ConA)-stimulated splenocytes. In contrast, neither antagonist significantly attenuated the CS-induced suppression of the B-cell mitogenic response to LPS, interleukin-2 production, natural killer cell activity, or mitogenic responsiveness of blood lymphocytes. Thus it is likely that multiple mechanisms are involved in CS-induced immune alterations and these results clearly implicate beta 1 and beta 2-adrenergic receptors in a subset of immunomodulatory effects.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Luecken LJ,Lysle DTdoi
10.1016/0165-5728(92)90014-csubject
Has Abstractpub_date
1992-06-01 00:00:00pages
209-19issue
3eissn
0165-5728issn
1872-8421pii
0165-5728(92)90014-Cjournal_volume
38pub_type
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doi:10.1016/j.jneuroim.2007.09.019
更新日期:2008-01-01 00:00:00
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更新日期:2005-02-01 00:00:00
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doi:10.1016/j.jneuroim.2013.01.013
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doi:10.1016/0165-5728(87)90097-x
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journal_title:Journal of neuroimmunology
pub_type: 临床试验,杂志文章
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更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:To develop a cell-based assay (CBA) to detect aquaporin 1 (AQP1) antibodies and determine sensitivity/specificity in patients with neuromyelitis optica (NMO) spectrum disorders. METHODS:A HEK-293T transfected cell model expressing AQP1 was established and detected to be serum AQP1 antibodies. RESULTS:AQP1 a...
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doi:10.1016/j.jneuroim.2014.06.003
更新日期:2014-08-15 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2003.08.017
更新日期:2003-10-01 00:00:00
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2003.10.049
更新日期:2004-01-01 00:00:00
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