Abstract：
:In studies of patients in Norway with multiple sclerosis (MS), we have found cross reactive autoantibodies related to the Epstein Barr virus nuclear antigen-1 (EBNA-1). The MS patients had elevated IgG antibody to EBNA-1, as measured by reactivity with a synthetic glycine/alanine peptide, P62, which represents the glycine/alanine repeat in EBNA-1. The mean titer of anti-P62 in patients with acute relapse at the time of assay was significantly higher than in the remaining patients. Patients with remitting/relapsing MS also had elevated autoantibody to a lymphocyte protein, p542, cross reactive with EBNA-1 through a glycine/serine epitope. High titered anti-EBNA-1 antibodies from some MS, as well as from some SLE sera, were shown to cross react with 80-82 kDa and 60 kDa proteins in neuroglial cells.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Vaughan JH,Riise T,Rhodes GH,Nguyen MD,Barrett-Connor E,Nyland Hdoi
10.1016/0165-5728(96)00069-0subject
Has Abstractpub_date
1996-09-01 00:00:00pages
95-102issue
1-2eissn
0165-5728issn
1872-8421pii
0165-5728(96)00069-0journal_volume
69pub_type
杂志文章abstract：:Cell lines of autoimmune T-lymphocytes have been established in several neuroimmunological model diseases and also in a human neurological autoimmune disease, myasthenia gravis. These cell lines generally have the T helper/inducer phenotype and recognize autoantigen in the context of class II histocompatibility antige...
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journal_title：Journal of neuroimmunology
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2010-04-15 00:00:00
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journal_title：Journal of neuroimmunology
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更新日期：1994-07-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2002-01-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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更新日期：2006-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0165-5728(88)90119-1
更新日期：1988-03-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2003-07-01 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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更新日期：2015-06-15 00:00:00
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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更新日期：1998-06-01 00:00:00
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更新日期：1984-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1998-03-15 00:00:00
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journal_title：Journal of neuroimmunology
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更新日期：1989-06-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of neuroimmunology
pub_type： 杂志文章
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更新日期：2009-01-03 00:00:00
abstract：:Narcolepsy was first shown to be tightly associated with HLA-DR2 and DQ1 in 1983, suggesting a possible autoimmune mechanism. Early investigations failed to demonstrate this hypothesis, postulating that HLA-DR2 was only a linkage marker for another, unknown narcolepsy-causing gene. The autoimmune hypothesis is now bei...
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pub_type： 杂志文章,评审
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更新日期：2001-07-02 00:00:00
abstract：:Matrix metalloproteinase 9 (MMP9) plays an important role in the pathogenesis of multiple sclerosis (MS). However, the impact of genetic variants affecting MMP9 on MS susceptibility is still in debate. We could not detect an association of MMP9 SNPs with MS on a genome-wide significance level by SNP genotyping, follow...
journal_title：Journal of neuroimmunology
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更新日期：2015-02-15 00:00:00
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journal_title：Journal of neuroimmunology
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更新日期：2014-09-15 00:00:00
