MS susceptibility is not affected by single nucleotide polymorphisms in the MMP9 gene.

abstract：:DNA damage-, DNA repair-, and apoptosis-related gene expression in CD3(+) T lymphocytes of BALB/c mice subjected to 2-h restraint stress were compared to that in CD3(+)T lymphocytes from control mice. Using targeted cDNA arrays, significant increases in expression of genes serving as sensors of DNA damage, including M...

journal_title：Journal of neuroimmunology

authors： Flint MS,Carroll JE,Jenkins FJ,Chambers WH,Han ML,Baum A

更新日期：2005-10-01 00:00:00

abstract：:Thymic function in myasthenic patients was examined using two biochemical markers which specifically define a population of cortisone-sensitive cortical thymocytes. The enzymatic activities of terminal deoxynucleotidyl transferase (TdT) and adenosine deaminase (ADA) were determined in 13 samples. High contents of both...

journal_title：Journal of neuroimmunology

authors： Vezzoni P,Fiacchino F,Clerici L,Sghirlanzoni A,Cerrato D,Peluchetti D,Lucchini R,Raineri M,Cornelio F

更新日期：1984-09-01 00:00:00

abstract：:Patients with small-cell carcinoma of the lung and paraneoplastic encephalomyelitis develop antibodies (anti-Hu) against HuD, a member of a family of neuronal specific RNA-binding proteins, which are also expressed by the tumor. In order to determine if the human HuD paraneoplastic antigen shares immunogenic regions b...

journal_title：Journal of neuroimmunology

authors： Sillevis Smitt P,Manley G,Dalmau J,Posner J

更新日期：1996-12-01 00:00:00

abstract：:Apolipoprotein E (ApoE) functions as a ligand in receptor-mediated endocytosis of lipoprotein particles and has been demonstrated to play a role in antigen presentation. To explore the contribution of ApoE during autoimmune central nervous system (CNS) demyelination, we examined the clinical, cellular immune function,...

journal_title：Journal of neuroimmunology

authors： Shin S,Walz KA,Archambault AS,Sim J,Bollman BP,Koenigsknecht-Talboo J,Cross AH,Holtzman DM,Wu GF

更新日期：2014-06-15 00:00:00

abstract：:Bone marrow stromal cells (BMSCs) are strong candidates for cell therapy against human autoimmune diseases. Intravenous administration of syngenic BMSCs to EAMG-model rats effectively ameliorated the disease, partially through a TGF-beta-dependent mechanism. The proliferative ability of T or B cells from EAMG rats was...

journal_title：Journal of neuroimmunology

authors： Kong QF,Sun B,Bai SS,Zhai DX,Wang GY,Liu YM,Zhang SJ,Li R,Zhao W,Sun YY,Li N,Wang Q,Peng HS,Jin LH,Li HL

更新日期：2009-02-15 00:00:00

abstract：:Interleukin-6 (IL-6) can activate gastrointestinal submucosal neurons, with associated implications for motility and secretory function. Patients with irritable bowel syndrome (IBS) have elevated levels of circulating IL-6. Colons from the Wistar Kyoto (WKY) rat model of IBS secrete more IL-6 (12.84 pg/ml) than contro...

journal_title：Journal of neuroimmunology

authors： O'Malley D,Dinan TG,Cryan JF

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:It will provide a reference for early detection, early diagnosis and early treatment of atypical primary Sjogren syndrome with neurological impairment as the first symptom. METHODS:Case report and Literature review. RESULTS:Here we report a 30-year-old woman diagnosed with trigeminal damage secondary to pSS w...

journal_title：Journal of neuroimmunology

authors： Yuan J,Gong L,Wu H,Chen Q,Wang J,Chen W,Wang X,Ren C

更新日期：2018-11-15 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML) is a disease of the central nervous system (CNS) with destructive infection of oligodendrocytes by JC virus. PML belongs to the opportunistic infections. It is observed in patients with HIV infection, lymphoid malignancies, after organ- and stem cell transplantations an...

journal_title：Journal of neuroimmunology

authors： Weissert R

更新日期：2011-02-01 00:00:00

abstract：:The blood brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCB) limit the influx of immune mediators and bloodstream compounds into the central nervous system (CNS). Upon injury or infection, the integrity of these barriers is compromised and leukocyte infiltration occurs. The BCB is located in the choro...

journal_title：Journal of neuroimmunology

authors： Alvarez JI,Teale JM

更新日期：2007-07-01 00:00:00

abstract：:To explore the role of circular RNAs (circRNAs) in pediatric anti-N-methyl-d-aspartate (NMDA) receptor encephalitis, we assessed the profiles of circRNAs and mRNAs in blood leukocytes from anti-NMDA receptor encephalitis patients and healthy controls using microarray analysis. 1196 circRNAs and 719 mRNAs (change ≥2, p...

journal_title：Journal of neuroimmunology

authors： Guo J,Han B,Wang J,Zhang L,Chen N,Sun W,Gao Y

更新日期：2020-11-15 00:00:00

abstract：:A B-cell activating factor of the tumor necrosis factor (TNF) family (BAFF) is an essential B-cell survival factor. Myasthenia gravis (MG) is one of the most typical antibody-mediated autoimmune disorders. To test whether serum BAFF levels are increased in MG patients, we compared the serum BAFF levels of 40 MG patien...

journal_title：Journal of neuroimmunology

authors： Kim JY,Yang Y,Moon JS,Lee EY,So SH,Lee HS,Park KD,Choi YC

更新日期：2008-08-13 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic inflammatory myelopathy. The pathophysiology of HAM/TSP is not yet fully understood; therefore, effective therapy remains a challenging issue. This study was designed to evaluate the efficacy of interfe...

journal_title：Journal of neuroimmunology

authors： Rafatpanah H,Rezaee A,Etemadi MM,Hosseini RF,Khorram B,Afsahr L,Taylor G,Mokhber N,Mahmoudi M,Abbaszadegan MR,Foroghipor M,Hashemi P,Amiri A,Tehrani M,Azarpazhooh A,Azarpazhooh MR

更新日期：2012-09-15 00:00:00

abstract：:Uncontrolled inflammation is considered to exacerbate the neuronal loss that follows spinal cord trauma. However, controlled inflammation response appears to be beneficial. Skin-coincubated macrophages injected into contused spinal cord of rats resulted in improved motor recovery and reduced spinal cyst formation. The...

journal_title：Journal of neuroimmunology

authors： Bomstein Y,Marder JB,Vitner K,Smirnov I,Lisaey G,Butovsky O,Fulga V,Yoles E

更新日期：2003-09-01 00:00:00

abstract：:The kinetics and magnitude of SP receptor expression was determined for bronchoalveolar leukocyte cell subsets from BALB/c mice in the primary immune response to respiratory syncytial virus (RSV) and human parainfluenza virus-3 (PIV3) infection, and in the secondary immune response to RSV and PIV3 challenge. In both t...

journal_title：Journal of neuroimmunology

authors： Tripp RA,Barskey A,Goss L,Anderson LJ

更新日期：2002-08-01 00:00:00

abstract：:Failure of CD95-mediated apoptosis as a potential negative regulatory mechanism of T cell expansion may be involved in T cell-mediated autoimmune diseases such as multiple sclerosis (MS). Recently, soluble CD95 has been shown to be elevated in MS patients with active disease. Here, we report that the sera of MS patien...

journal_title：Journal of neuroimmunology

authors： Zipp F,Otzelberger K,Dichgans J,Martin R,Weller M

更新日期：1998-06-15 00:00:00

abstract：:IgG fractions of sera containing anti-Hu antibodies or control sera were incubated with Hu-positive and Hu-negative cell lines. Anti-Hu IgG specifically localized in the nucleus of Hu-positive cells. Anti-Hu-positive and control sera were incubated with Hu-positive cells and human complement or peripheral blood mononu...

journal_title：Journal of neuroimmunology

authors： Hormigo A,Lieberman F

更新日期：1994-12-01 00:00:00

abstract：:Asthma is highly comorbid with anxiety in youth. We investigated the hypothalamic-pituitary-adrenal (HPA) axis and microglia as mechanisms underlying asthma and anxiety comorbidity. We induced asthma symptoms in developing BALB/cJ mice with house dust mite (HDM) for airway inflammation and methacholine (MCH) for bronc...

journal_title：Journal of neuroimmunology

authors： Caulfield JI,Schopf KJ,Cavigelli SA

更新日期：2020-11-25 00:00:00

abstract：:Antisera raised to the astrocyte intermediate filament structural protein stained elements in the peripheral nerves of several species. These elements were not associated with myelinated nerve fibers, were more common in splenic and vagus nerves than in the sciatic nerve, and persisted after nerve transection. In teas...

journal_title：Journal of neuroimmunology

authors： Fields KL,Yen SH

更新日期：1985-06-01 00:00:00

abstract：:Zymosan has previously been reported to have both pro-inflammatory and anti-inflammatory effects. Here we demonstrate that low dose zymosan prevented or reversed chronic and relapsing paralysis in EAE. In suppressing CNS autoimmune inflammation, zymosan not only regulated APC costimulator and MHC class II expression, ...

journal_title：Journal of neuroimmunology

authors： Li H,Gonnella P,Safavi F,Vessal G,Nourbakhsh B,Zhou F,Zhang GX,Rostami A

更新日期：2013-01-15 00:00:00

abstract：:The in vivo relationship of interleukin-2 (IL-2) to the local humoral immune response within the central nervous system (CNS) in patients with multiple sclerosis (MS) is hitherto largely unknown. Intrathecal levels of IL-2 and soluble IL-2 receptors (sIL-2R) were correlated to the local CNS synthesis of immunoglobulin...

journal_title：Journal of neuroimmunology

authors： Sharief MK,Hentges R,Thompson EJ

更新日期：1991-04-01 00:00:00

abstract：:Fas (CD95) and Fas ligand (FasL, CD95L) have been implicated to be involved in the acute inflammatory response by attracting neutrophils and regulating their survival. Increased levels of soluble Fas and FasL are found in cerebrospinal fluid (CSF) samples of patients with bacterial meningitis but not in controls. Func...

journal_title：Journal of neuroimmunology

authors： Paul R,Angele B,Sporer B,Pfister HW,Koedel U

更新日期：2004-07-01 00:00:00

abstract：:Inflammatory mediators are involved in the pathogenesis of focal ischemic brain damage. In this study we used quantitative reverse transcriptase-polymerase chain reaction to analyze the spatiotemporal pattern of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and inducible nitric oxide synthase ...

journal_title：Journal of neuroimmunology

authors： Jander S,Schroeter M,Stoll G

更新日期：2000-09-22 00:00:00

abstract：:Tissue cysts, the hallmark of chronic Toxoplasma gondii infection, are predominantly located in the brain making clearance of the parasite difficult. Currently available anti-T. gondii drugs are ineffective on cysts and fail to prevent reactivation of latent toxoplasmosis. We examined whether abrogation of inhibitory ...

journal_title：Journal of neuroimmunology

authors： Xiao J,Li Y,Yolken RH,Viscidi RP

更新日期：2018-06-15 00:00:00

abstract：:The extent to which symptomatic improvement in patients with multiple sclerosis treated with intravenous methylprednisolone depends on immunological actions of corticosteroids is unknown. In this study the effect of methylprednisolone on circulating T and B cell function has been assessed in vitro and in vivo. Low mol...

journal_title：Journal of neuroimmunology

authors： Kirk P,Compston A

更新日期：1990-01-01 00:00:00

abstract：:Depression and chronic fatigue are frequently present in multiple sclerosis (MS); however, the prevalence rates have not been investigated in neuromyelitis optica (NMO). Thirty-nine consecutive NMO and 75 MS patients were compared using self-rating questionnaires for depressive states, daily activity, and fatigue, as ...

journal_title：Journal of neuroimmunology

authors： Akaishi T,Nakashima I,Misu T,Fujihara K,Aoki M

更新日期：2015-06-15 00:00:00

abstract：:Multiple sclerosis (MS) patients make antibodies to heterogeneous nuclear ribonuclear protein A1 (hnRNP-A1), a nucleocytoplasmic protein. We hypothesized this autoimmune reaction might contribute to neurodegeneration. Antibodies from MS patients reacted with hnRNP-A1-'M9', its nuclear translocation sequence. Transfect...

journal_title：Journal of neuroimmunology

authors： Lee S,Xu L,Shin Y,Gardner L,Hartzes A,Dohan FC,Raine C,Homayouni R,Levin MC

更新日期：2011-06-01 00:00:00

abstract：:Neurocysticercosis (NC) presents two broad clinical entities: extraparenchymal (EP-NC) and parenchymal (P-NC). Using ELISA methodology, we demonstrate autoantibodies to tubulin and the Major oligodendrocyte glycoprotein (MOG) in the CSF of most, but not all, EP-NC samples. Levels of these autoantibodies were considera...

journal_title：Journal of neuroimmunology

authors： Parkhouse RME,Sciutto E,Hernández M,Cortez MM,Carpio A,Fleury A

更新日期：2020-12-15 00:00:00

abstract：:Microglia cells are the principal immune effector elements of the brain responding to any pathological event. To elucidate the possible role of microglia in initial non-inflammatory demyelination in canine distemper virus (CDV) infection, microglia from experimentally CDV infected dogs were isolated ex vivo by density...

journal_title：Journal of neuroimmunology

authors： Stein VM,Czub M,Schreiner N,Moore PF,Vandevelde M,Zurbriggen A,Tipold A

更新日期：2004-08-01 00:00:00

abstract：:The effect of the bm12 mutation on susceptibility to MOG-induced EAE, TCR repertoire and fine epitope specificity of the encephalitogenic T-cells, was assessed. prMOG35-55 was encephalitogenic for H-2bm12 and H-2b mice. Despite only minor differences in TCRVbeta expression and fine epitope specificity, H-2bm12/ and H-...

journal_title：Journal of neuroimmunology

authors： Mendel I,Gur H,Kerlero de Rosbo N,Ben-Nun A

更新日期：1999-04-01 00:00:00

abstract：:Cloned cerebrovascular endothelial cells (CVE) persistently infected with Theiler's virus (PI-CVE) have been established and characterized. The CVE were derived from strains of mice that are susceptible (SJL/J and CBA) and resistant (BALB/c) to Theiler's virus-induced demyelination (TVID). The cells were persistently ...

journal_title：Journal of neuroimmunology

authors： Sapatino BV,Petrescu AD,Rosenbaum BA,Smith R 3rd,Piedrahita JA,Welsh CJ

更新日期：1995-11-01 00:00:00