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Extraparenchymal human neurocysticercosis induces autoantibodies against brain tubulin and MOG35-55 in cerebral spinal fluid.

Abstract：

:Neurocysticercosis (NC) presents two broad clinical entities: extraparenchymal (EP-NC) and parenchymal (P-NC). Using ELISA methodology, we demonstrate autoantibodies to tubulin and the Major oligodendrocyte glycoprotein (MOG) in the CSF of most, but not all, EP-NC samples. Levels of these autoantibodies were considerably reduced or absent in the P-NC samples. There was a striking correlation between levels of anti-tubulin and anti-MOG, and the significant correlation between the levels of autoantibodies and cellularity in the CSF, suggests that stimulation of the autoantibody response may be a function of cerebral inflammation. A hypothetical model to describe the pathogenesis of EP-NC is presented.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Parkhouse RME,Sciutto E,Hernández M,Cortez MM,Carpio A,Fleury A

doi

10.1016/j.jneuroim.2020.577389

subject

Has Abstract

pub_date

2020-12-15 00:00:00

pages

577389

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(20)30486-0

journal_volume

349

pub_type

杂志文章,多中心研究

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