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Regional difference in inflammatory response to LPS-injection in the brain: role of microglia cell density.

Abstract：

:To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays using three different densities of N13 microglia stimulated with LPS. Our results showed that induction of pro-inflammatory factors as TNF-α and iNOS was directly related to cell density, meanwhile the induction of the anti-inflammatory IL-10 was inversely related to cell density. Accordingly, in vivo assays showed that after LPS-injection, iNOS expression was more intense in substantia nigra, a brain area showing specific susceptibility to neurodegeneration after microglia activation, whereas IL-10 expression was more sustained in striatum, an area resistant to damage. These results support that microglia density is pivotal to control the balance between pro- and anti-inflammatory factors release.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Pintado C,Revilla E,Vizuete ML,Jiménez S,García-Cuervo L,Vitorica J,Ruano D,Castaño A

doi

10.1016/j.jneuroim.2011.06.017

subject

Has Abstract

pub_date

2011-09-15 00:00:00

pages

44-51

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(11)00190-1

journal_volume

238

pub_type

杂志文章

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