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Interferon-gamma-inducible genes in primary glial cells of the central nervous system: comparisons of astrocytes with microglia and Lewis with brown Norway rats.

Abstract：

:We compared the expression of various interferon-gamma (IFN-gamma)-inducible mRNAs in primary rat astrocytes and microglia. Of 11 different mRNAs inducible by IFN-gamma in a macrophage cell line, RAW 264.7, only eight were induced in both types of glia, which included mRNAs encoding the transcriptional factors, IRF-1, LRF-1 and ZIF-268; members of the chemokine family, crg-2/IP-10 and MIG; beta 2-microglobulin and metallothionein-II. The patterns of induction of the mRNAs were more similar between astrocytes and microglia than with RAW 264.7 cells. Comparison of astrocytes from Lewis and Brown Norway rats showed no major differences in the levels of the crg mRNAs or in the amount of Crg-2 protein induced by IFN-gamma.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Vanguri P

doi

10.1016/0165-5728(94)00131-7

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

35-43

issue

1

eissn

0165-5728

issn

1872-8421

pii

0165572894001317

journal_volume

56

pub_type

杂志文章

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