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Immunological patterns identifying disease course and evolution in multiple sclerosis patients.

Abstract：

:Reliable, and easy to measure, immunological markers able to denote disease characteristics in multiple sclerosis (MS) patients are still lacking. We applied a multivariate statistical analysis on results obtained by measuring-by real-time RT-PCR-mRNA levels of 25 immunological relevant molecules in PBMCs from 198 MS patients. The combined measurement of mRNA levels of IL-1beta, TNF-alpha, TGF-beta, CCL20 and CCR3 was able to distinguish MS patients from healthy individuals. CXCR5, CCL5, and CCR3 combined mRNA levels identify primary progressive MS patients while TNF-alpha, IL-10, CXCL10 and CCR3 differentiate relapsing MS patients. Our results indicate that multi-parametric analysis of mRNA levels of immunological relevant molecules in PBMCs may represent a successful strategy for the identification of putative peripheral markers of disease state and disease activity in MS patients.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Furlan R,Rovaris M,Martinelli Boneschi F,Khademi M,Bergami A,Gironi M,Deleidi M,Agosta F,Franciotta D,Scarpini E,Uccelli A,Zaffaroni M,Kurne A,Comi G,Olsson T,Filippi M,Martino G

doi

10.1016/j.jneuroim.2005.04.012

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

192-200

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(05)00165-7

journal_volume

165

pub_type

杂志文章

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