abstract：:This study aimed to evaluate the effects of leptin, ghrelin and neuropeptide-Y on the development of nonconvulsive seizure activity and their role on combating oxidative stress and cytokines produced by the systemic immune response in the WAG/Rij rat model for genetic absence epilepsy. Current study showed that all th...

journal_title：Journal of neuroimmunology

authors： Oztas B,Sahin D,Kir H,Kuskay S,Ates N

更新日期：2021-02-15 00:00:00

abstract：:This study aimed to determine the seasonal impact on the clinical onset of inflammatory neurological diseases of the central nervous system by analyzing the onset month with information on clinical manifestations in Japanese patients. As a result, patients with anti-aquaporin-4 antibodies (AQP4-IgG)-positive neuromyel...

journal_title：Journal of neuroimmunology

authors： Akaishi T,Fujimori J,Takahashi T,Misu T,Takai Y,Nishiyama S,Kaneko K,Ogawa R,Abe M,Ishii T,Aoki M,Fujihara K,Nakashima I

更新日期：2020-12-15 00:00:00

abstract：:Neurocysticercosis (NC) presents two broad clinical entities: extraparenchymal (EP-NC) and parenchymal (P-NC). Using ELISA methodology, we demonstrate autoantibodies to tubulin and the Major oligodendrocyte glycoprotein (MOG) in the CSF of most, but not all, EP-NC samples. Levels of these autoantibodies were considera...

journal_title：Journal of neuroimmunology

authors： Parkhouse RME,Sciutto E,Hernández M,Cortez MM,Carpio A,Fleury A

更新日期：2020-12-15 00:00:00

abstract：:Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by communication deficits, impaired social interactions, and restricted stereotypical behaviors. Several immune cells are associated with immune dysfunction in ASD; however, IL-31 has not been explored in ASD. This study aims to ...

journal_title：Journal of neuroimmunology

authors： Ahmad SF,Ansari MA,Nadeem A,Bakheet SA,Al-Ayadhi LY,Alsaad AMS,Assiri MA,Al-Mazroua HA,Attia SM

更新日期：2020-12-15 00:00:00

abstract：:Asthma is highly comorbid with anxiety in youth. We investigated the hypothalamic-pituitary-adrenal (HPA) axis and microglia as mechanisms underlying asthma and anxiety comorbidity. We induced asthma symptoms in developing BALB/cJ mice with house dust mite (HDM) for airway inflammation and methacholine (MCH) for bronc...

journal_title：Journal of neuroimmunology

authors： Caulfield JI,Schopf KJ,Cavigelli SA

更新日期：2020-11-25 00:00:00

abstract：:Opsoclonus is an ocular motility disorder characterized by spontaneous, arrhythmic conjugate saccades of varying amplitude occurring in all directions of gaze without normal intersaccadic interval. Etiological spectrum of opsoclonus encompasses paraneoplastic and neoplastic conditions, infectious and para-infectious e...

journal_title：Journal of neuroimmunology

authors： Ghosh R,Dubey S,Ray BK,Purkait S,Pandit A,Benito-León J

更新日期：2020-11-15 00:00:00

abstract：:To explore the role of circular RNAs (circRNAs) in pediatric anti-N-methyl-d-aspartate (NMDA) receptor encephalitis, we assessed the profiles of circRNAs and mRNAs in blood leukocytes from anti-NMDA receptor encephalitis patients and healthy controls using microarray analysis. 1196 circRNAs and 719 mRNAs (change ≥2, p...

journal_title：Journal of neuroimmunology

authors： Guo J,Han B,Wang J,Zhang L,Chen N,Sun W,Gao Y

更新日期：2020-11-15 00:00:00

abstract：:Increased plasma levels of interleukin-6 (IL-6) in response to acute hypoglycemia have been well documented. Aiming to study the interaction between IL-6 and counter-regulatory hormones during hypoglycemic stress we conducted an exploratory single center study involving 26 adult patients undergoing insulin tolerance t...

journal_title：Journal of neuroimmunology

authors： Drummond JB,Soares BS,Vieira ELM,Pedrosa W,Teixeira AL,Ribeiro-Oliveira A Jr

更新日期：2020-11-13 00:00:00

abstract：BACKGROUND:Although the role of inflammation in epilepsy pathogenesis has been extensively investigated, the inflammasome complex, a key component of neuroinflammation, has been understudied in epilepsy patients. METHODS:To better understand the involvement of this system in epilepsy, levels of inflammasome complex co...

journal_title：Journal of neuroimmunology

authors： Ulusoy C,Vanlı-Yavuz EN,Şanlı E,Timirci-Kahraman Ö,Yılmaz V,Bebek N,Küçükali Cİ,Baykan B,Tüzün E

更新日期：2020-10-15 00:00:00

abstract：:Ganoderma lucidum extract (GLE) is a potent ancient Asian remedy for the treatment of various diseases. This study investigated GLE preventive effects on LPS-stimulated inflammation of BV-2 microglial cells. The results show that pre-treatment with GLE decreased expression of pro-inflammatory cytokines: G-CSF, IL1-α, ...

journal_title：Journal of neuroimmunology

authors： Hilliard A,Mendonca P,Soliman KFA

更新日期：2020-08-15 00:00:00

abstract：:Microglial inflammation plays a pivotal role in the pathogenesis of S. aureus induced brain abscesses. The objective of this study was to regulate microglial activation by the combinatorial treatment of ciprofloxacin either with dexamethasone or celecoxib via targeting M1 and M2 polarization. The antibiotic-immunomodu...

journal_title：Journal of neuroimmunology

authors： Dey R,Bishayi B

更新日期：2020-07-15 00:00:00

abstract：:Stroke is the leading cause of death and the main cause of disability in surviving patients. The detrimental interaction between immune cells, glial cells, and matrix components in stroke pathology results in persistent inflammation that progresses to fibrosis. A substantial effort is being directed toward understandi...

journal_title：Journal of neuroimmunology

authors： Amruta N,Rahman AA,Pinteaux E,Bix G

更新日期：2020-07-09 00:00:00

abstract：:Growing evidence suggests a role for brain-gut-microbiota axis in affective disorders including major depression and bipolar disorder (BD). Herein, we aim to explore, by employing germ-free (GF) mice, the effect of the indigenous microbiota in the development of mania-like behavior. Conventional and GF mice were evalu...

journal_title：Journal of neuroimmunology

authors： de Miranda AS,Vieira ÉLM,Dos Reis Bastos J,Ferreira RN,Nicoli JR,Teixeira MM,Vieira LQ,Moreira FA,Teixeira AL

更新日期：2020-06-16 00:00:00

abstract：:Toll-like receptors (TLRs) are sensors of pathogen-associated molecules that trigger inflammatory signalling in innate immune cells including macrophages. All TLRs, with the exception of TLR3, promote intracellular signalling via recruitment of the myeloid differentiation factor 88 (MyD88) adaptor, while TLR3 signals ...

journal_title：Journal of neuroimmunology

authors： Fitzpatrick JM,Minogue E,Curham L,Tyrrell H,Gavigan P,Hind W,Downer EJ

更新日期：2020-06-15 00:00:00

abstract：:Predisposing factors before the onset of neuromyelitis optica spectrum disorders (NMOSD) have not been systematically evaluated by now. We investigated the detailed pre-onset history in consecutive NMOSD patients. Thirteen of the enrolled 53 NMOSD patients (24.5%) had accompanying autoimmune diseases, such as Sjögren'...

journal_title：Journal of neuroimmunology

authors： Akaishi T,Takahashi T,Fujihara K,Misu T,Abe M,Ishii T,Aoki M,Nakashima I

更新日期：2020-06-15 00:00:00

abstract：:Antiphospholipid syndrome (APS), an autoantibody mediated disease, is characterized by presence of antibodies against the proteins bound to the phospholipid membranes. The antibodies are predominantly formed against beta-2-glycoprotein I (b2GPI) which is considered pathogenic, but presence of lupus anticoagulant is a ...

journal_title：Journal of neuroimmunology

authors： Aneja J,Kuppili PP,Paul K,Panda S,Purohit A

更新日期：2020-06-15 00:00:00

abstract：:Relative telomere length (TL) is regarded as a biomarker of biological age. Accelerated immune aging, as represented by TL reduction, has been demonstrated in autoimmune diseases, including multiple sclerosis (MS). However, it is still unresolved whether telomere shortening is the cause or the consequence of the patho...

journal_title：Journal of neuroimmunology

authors： Habib R,Ocklenburg S,Hoffjan S,Haghikia A,Epplen JT,Arning L

更新日期：2020-04-15 00:00:00

abstract：:Stiff person spectrum disorders (SPSD) are a broad group of immune-mediated disorders. Clinical presentations include classical stiff person syndrome (SPS), focal SPS, and progressive encephalomyelitis with rigidity and myoclonus (PERM). The most frequently associated antibodies are anti-GAD65, anti-GlyR, anti-amphiph...

journal_title：Journal of neuroimmunology

authors： Bernardo F,Rebordão L,Rêgo A,Machado S,Passos J,Costa C,Cruz S,Pinto AN,Santos M

更新日期：2020-04-15 00:00:00

abstract：:Our work consists of a pilot study to characterize circulating Th/c1, Th/c2, Th/c17, Treg and Tfh-like populations and IL-17 serum levels of relapsing-remitting (RR) MS patients treated with IFN-β, compared with healthy controls. In remission RRMS patients, we observe increased Th/c17 cells frequency committed to a Th...

journal_title：Journal of neuroimmunology

authors： Monteiro A,Rosado P,Rosado L,Fonseca AM,Paiva A

更新日期：2020-02-15 00:00:00

abstract：BACKGROUND/PURPOSE:In anti-myelin associated glycoprotein (anti-MAG) neuropathies, there is evidence that anti-MAG antibodies are pathogenic but numerous studies report the absence or a weak correlation between the titers of these antibodies and disease course. In this study we assessed the relationships between MAG an...

journal_title：Journal of neuroimmunology

authors： Neil J,Choumet V,Beadon K,Delmont E,Ghillani P,Boucraut J,Musset L,Léger JM

更新日期：2020-02-15 00:00:00

abstract：:To clarify the immunogenetic background of patients with immunoglobulin G (IgG)4 anti-neurofascin 155 (NF155) antibody-positive chronic inflammatory demyelinating polyneuropathy (CIDP), we genotyped the extended human leukocyte antigen (HLA) haplotypes in 22 Japanese patients with this disorder and compared them with ...

journal_title：Journal of neuroimmunology

authors： Ogata H,Isobe N,Zhang X,Yamasaki R,Fujii T,Machida A,Morimoto N,Kaida K,Masuda T,Ando Y,Kuwahara M,Kusunoki S,Nakamura Y,Matsushita T,Kira JI

更新日期：2020-02-15 00:00:00

abstract：:Complement-dependent disruption of motor endplate is detected in anti-acetylcholine receptor (AChR) antibody-positive myasthenia gravis (MG). We measured serum AChR α1 subunit protein levels, which may be associated with neuromuscular damage, in 55 patients with MG (47 were seropositive and 8 were negative) and in 20 ...

journal_title：Journal of neuroimmunology

authors： Uzawa A,Ozawa Y,Yasuda M,Oda F,Kojima Y,Kawaguchi N,Kanai T,Himuro K,Kuwabara S

更新日期：2020-02-15 00:00:00

abstract：:Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare and treatable variant of CAA likely due to an autoimmune response directed toward beta-amyloid deposits. Cognitive and behavioral manifestations are the most common symptoms, followed by focal neurological signs, headache and seizures, associated with...

journal_title：Journal of neuroimmunology

authors： Poli L,De Giuli V,Piazza F,Volonghi I,Bigliardi G,Vallone S,Nichelli PF,Gasparotti R,Zini A,Padovani A,Pezzini A

更新日期：2020-01-15 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a common animal model that has the same pathology and pathogenesis as multiple sclerosis (MS). Dendritic cells (DCs) exert an important role in central and peripheral tolerance. DCs not only drive T cell priming and differentiation via playing antigen presentation fun...

journal_title：Journal of neuroimmunology

authors： Cao Q,Zheng C,Xie Z,Liu L,Zhu J,Jin T

更新日期：2020-01-15 00:00:00

abstract：:The neural transmission and plasticity can be differentially modulated by various elements of the immune system. Interferon-γ (IFN-γ) is a "pro-inflammatory" cytokine mainly produced by T lymphocytes, activates its corresponding receptor and plays important roles under both homeostatic and inflammatory conditions. How...

journal_title：Journal of neuroimmunology

authors： Flood L,Korol SV,Ekselius L,Birnir B,Jin Z

更新日期：2019-12-15 00:00:00

abstract：:Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are common demyelinating disorders of the central nervous system. The etiology and pathogenesis of MS and NMOSD remain unclear. The pathogenesis of these two diseases involves a genetic predisposition as well as environmental factors. NMOSD som...

journal_title：Journal of neuroimmunology

authors： Liang H,Gao W,Liu X,Liu J,Mao X,Yang M,Long X,Zhou Y,Zhang Q,Zhu J,Wang S,Jin T

更新日期：2019-12-15 00:00:00

abstract：:We present a 53-year-old woman who presented simultaneously with acute inflammatory demyelinating polyneuropathy, Graves' disease, leukocytoclastic vasculitis, elevated acetylcholine antibody receptor antibodies and a mediastinal mass. Thymectomy was performed and revealed a type A thymoma and the clinical picture and...

journal_title：Journal of neuroimmunology

authors： Sveinsson O,Piehl F,Aspegren O,Hietala MA

更新日期：2019-11-15 00:00:00

abstract：:To illustrate the accuracy of the fluorescence-activated cell sorting cell-based assay (FACS-CBA) and to detect anti-myelin oligodendrocyte glycoprotein (MOG) antibodies and ascertain the optimal method for positivity judgement, referencing the findings of microscopic CBA. We tested serum anti-MOG antibodies in 57 pat...

journal_title：Journal of neuroimmunology

authors： Sugimoto K,Mori M,Liu J,Tanaka S,Kaneko K,Oji S,Takahashi T,Uzawa A,Uchida T,Masuda H,Ohtani R,Nomura K,Hiwasa T,Kuwabara S

更新日期：2019-11-15 00:00:00

abstract：:Human cytomegalovirus (CMV) infection is asymptomatic in immunocompetent individuals. However, it can lead to disease in immunodeficient population. Little is known of the mechanisms underlying the pathogenicity of the virus. We investigated the impact of CMV infection on mouse nervous system. Peripheral nerves but no...

journal_title：Journal of neuroimmunology

authors： Oladiran O,Yang M,Rivera VAG,Shi X,Huang J,Fournier S,Zhang J

更新日期：2019-10-15 00:00:00

abstract：:An important extrahepatic consequence of Hepatitis C is its adverse impact on the central nervous system and cognitive performance. We aimed to determine whether there is a significant relationship between selected neurotransmitters and cytokines and cognitive performance in patients with Chronic Hepatitis C before an...

journal_title：Journal of neuroimmunology

authors： Weinstein AA,Estep JM,de Avila L,Curry M,Golabi P,Escheik C,Birerdinc A,Stepanova M,Price JK,Gerber L,Younossi ZM

更新日期：2019-10-15 00:00:00

abstract：:Activation of microglia cells play critical role in neuroinflammation after brain injury. Exosomes from adipose-derived stem cells (ADSC) possess immunoregulation effect similar with ADSC. We hypothesized that ADSC derived exosomes (ADSC-exosomes) could inhibit the activation of microglia cells and prevent neuroinflam...

journal_title：Journal of neuroimmunology

authors： Feng N,Jia Y,Huang X

更新日期：2019-09-15 00:00:00

abstract：:High mobility group box 1 (HMGB1) is a pro-inflammatory cytokine that emerges as a promising peripheral marker of inflammation. HMGB1 and C-reactive protein levels were assessed in plasma of control subjects and remitted patients with bipolar disorder (BD). HMGB1 levels were significantly higher in patients with BD as...

journal_title：Journal of neuroimmunology

authors： Marie-Claire C,Courtin C,Curis E,Bouaziz-Amar E,Laplanche JL,Jacob A,Etain B,Blanchard A,Bellivier F

更新日期：2019-09-15 00:00:00

abstract：:We describe the case of a 69-year-old man who presented with symptoms of headache and severe vision loss due to G4 immunoglobulin (IgG4) hypertrophic pachymeningitis (HP). The patient was initially responsive to corticotherapy, but vision loss progressed when steroid therapy was first tapered. No improvement was notic...

journal_title：Journal of neuroimmunology

authors： Soares C,Martins DF,Pestana-Silva R,Honavar M,Faria O,Abreu P,Costa A

更新日期：2019-09-15 00:00:00

abstract：:The experimental autoimmune encephalomyelitis (EAE) model is indispensable for autoimmunity research, but model-specific T cell dynamics are sparsely studied. We used next-generation immunosequencing across lymphoid organs, blood and spinal cord in response to immunization with myelin basic protein (MBP) to study T ce...

journal_title：Journal of neuroimmunology

authors： Schliffke S,Carambia A,Akyüz N,Thiele B,Herkel J,Binder M

更新日期：2019-07-15 00:00:00

abstract：:Acetylcholine receptor antibodies are very specific for myasthenia. During a large prospective cohort study of myasthenia, we encountered five patients, positive for acetylcholine receptor (AChR) antibodies by radioimmunoprecipitation assay (RIA), whose clinical course revealed diagnoses other than myasthenia. Two pat...

journal_title：Journal of neuroimmunology

authors： Maddison P,Sadalage G,Ambrose PA,Jacob S,Vincent A

更新日期：2019-07-15 00:00:00

abstract：:The adult mammalian spinal cord (SC) harbors neural stem cells (NSCs). The SC-NSCs are mostly quiescent during physiological conditions but are quickly activated in traumatic injury models. The SC-NSCs generate mostly glia, but are able to differentiate into neurons when affected by favourable conditions. An example i...

journal_title：Journal of neuroimmunology

authors： Covacu R,Brundin L

更新日期：2019-06-15 00:00:00

abstract：:The aim of the current review is to summarize the results of studies on the role of γδ T cells in the pathogenesis of multiple sclerosis and its animal model - the experimental autoimmune encephalomyelitis. Despite the fact that numerous studies have been performed, the role of γδ T is still not fully understood. It s...

journal_title：Journal of neuroimmunology

authors： Zarobkiewicz MK,Kowalska W,Roliński J,Bojarska-Junak AA

更新日期：2019-05-15 00:00:00

abstract：:Tacrolimus-induced encephalopathy presents with acute neurological symptoms such as headache, seizures, visual disturbances, hemiplegia, and altered mental status. A 60-year-old woman, presented to our clinic with a 4-month history of severe headache. She recently underwent kidney transplantation and was taking tacrol...

journal_title：Journal of neuroimmunology

authors： Smeralda CL,Gigli GL,Vogrig A,Marini A,Valente M

更新日期：2019-05-15 00:00:00

abstract：:Several studies have proposed cerebral malaria (CM) as a CD4+ and CD8+ T lymphocyte-mediated disease. However, there are no data regarding the recruitment and/or persistence of these cells in the CNS following the phase of infection resolution. Glutamate-mediate excitotoxicity has also been implicated in CM. Blockade ...

journal_title：Journal of neuroimmunology

authors： de Miranda AS,Ferreira RN,Vieira ÉLM,Abreu LKS,Brant F,Vieira LB,Ribeiro FM,Machado FS,Rachid MA,Teixeira AL

更新日期：2019-05-15 00:00:00

abstract：:Cigarette smoking is the most prominent significant cause of death and morbidity. It is recognised as a risk factor for a number of immune mediated, inflammatory diseases including multiple sclerosis (MS). Here, we review the complex immunological effects of smoking on the immune system, which include enhancement of i...

journal_title：Journal of neuroimmunology

authors： Alrouji M,Manouchehrinia A,Gran B,Constantinescu CS

更新日期：2019-04-15 00:00:00