Abstract:
:The expression of interleukin-1 beta (IL-1beta) mRNA was compared in the brain of inflammatory susceptible LEW/N and resistant F344/N rats at 3, 6, and 12 h after peripheral administration of lipopolysaccharide (LPS) or saline. No differences between strains were observed in the circumventricular organs (CVOs) and choroid plexus. At 12 h after LPS administration, increased IL-1beta mRNA expression was detected in the hypothalamus of LEW/N rats. In contrast, increased IL-1beta mRNA expression was detected in the cerebral cortex of F344/N rats. These data show region-specific differences of IL-1beta mRNA expression in the brain of these rat strains that differ in their susceptibility to inflammation.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Tonelli LH,Maeda S,Rapp KL,Sternberg EMdoi
10.1016/s0165-5728(03)00171-1subject
Has Abstractpub_date
2003-07-01 00:00:00pages
126-36issue
1-2eissn
0165-5728issn
1872-8421pii
S0165572803001711journal_volume
140pub_type
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