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Features of skin-coincubated macrophages that promote recovery from spinal cord injury.

Abstract：

:Uncontrolled inflammation is considered to exacerbate the neuronal loss that follows spinal cord trauma. However, controlled inflammation response appears to be beneficial. Skin-coincubated macrophages injected into contused spinal cord of rats resulted in improved motor recovery and reduced spinal cyst formation. The macrophages express elevated levels of cell-surface molecules CD80, CD86, CD54 and MHC-II, markers characteristic of antigen presenting cells (APCs). Additionally, skin-coincubation elevates secretion of interleukin-1 beta (IL-1 beta) and Brain-Derived Neurotrophic Factor (BDNF), and reduces secretion of tumor necrosis factor alpha (TNF-alpha). We propose that macrophages activated by skin-coincubation bolster neuroprotective immune activity in the spinal cord, making the environment less cytotoxic and less hostile to axonal regeneration.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Bomstein Y,Marder JB,Vitner K,Smirnov I,Lisaey G,Butovsky O,Fulga V,Yoles E

doi

10.1016/s0165-5728(03)00260-1

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

10-6

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165572803002601

journal_volume

142

pub_type

杂志文章

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