Neurobehavioral alterations in mice with a targeted deletion of the tumor necrosis factor-alpha gene: implications for emotional behavior.

abstract：:We have previously found a dramatic increase of corticotropin-releasing factor receptor (CRF-R1) production in splenic neutrophils of male C57BL/6N mice after application of an immunological stimulus. We demonstrate here that immobilization, a predominantly psychological stress, exhibited a similar effect. Shortly aft...

journal_title：Journal of neuroimmunology

authors： Radulovic M,Weber C,Spiess J

更新日期：2000-03-01 00:00:00

abstract：:The present investigations sought to determine whether the ventral tegmental area (VTA), basolateral amygdala (BLA), and nucleus accumbens shell (NAC) comprise a circuitry that mediates heroin-induced conditioned immunomodulation. Rats were given conditioning trials in which they received an injection of heroin upon p...

journal_title：Journal of neuroimmunology

authors： Szczytkowski JL,Fuchs RA,Lysle DT

更新日期：2011-08-15 00:00:00

abstract：:A large body of immunologic, epidemiologic, and genetic data indicate that tissue injury in multiple sclerosis (MS) results from an abnormal immune response to one or more myelin antigens that develops in genetically susceptible individuals after exposure to an as-yet undefined causal agent. The genetic component of M...

journal_title：Journal of neuroimmunology

authors： Oksenberg JR,Baranzini SE,Barcellos LF,Hauser SL

更新日期：2001-02-15 00:00:00

abstract：:Nitric oxide (NO) is implicated in inflammation and hypothalamic-pituitary responses to immune stimuli; however, the specific role of NO from neurons during stress-induced immune responses remains unspecified. We measured antigen-specific delayed-type-hypersensitivity (DTH) responses in the skin of wild-type (WT) and ...

journal_title：Journal of neuroimmunology

authors： Bilbo SD,Hotchkiss AK,Chiavegatto S,Nelson RJ

更新日期：2003-07-01 00:00:00

abstract：:The acetylcholine receptor (AChR) is the main target antigen in myasthenia gravis (MG), but about 15% of patients with typical immunologically mediated MG do not have detectable anti-AChR antibodies. Previous studies showed that plasma from these 'seronegative' patients (SNMG) reduced AChR function in the human AChR-e...

journal_title：Journal of neuroimmunology

authors： Li Z,Forester N,Vincent A

更新日期：1996-02-01 00:00:00

abstract：:Myasthenia gravis (MG) is a neuromuscular disease thought to have an autoimmune etiology. The acetylcholine receptor has been considered the primary site of antibody binding; however, other muscle components may be involved in the pathogenesis of myasthenia gravis. This study describes a hypertonic sucrose extract of ...

journal_title：Journal of neuroimmunology

authors： Mehl VS,Lang RW

更新日期：1984-08-01 00:00:00

abstract：:Microglia cells are the principal immune effector elements of the brain responding to any pathological event. To elucidate the possible role of microglia in initial non-inflammatory demyelination in canine distemper virus (CDV) infection, microglia from experimentally CDV infected dogs were isolated ex vivo by density...

journal_title：Journal of neuroimmunology

authors： Stein VM,Czub M,Schreiner N,Moore PF,Vandevelde M,Zurbriggen A,Tipold A

更新日期：2004-08-01 00:00:00

abstract：:Peripheral challenge with a viral mimetic, polyinosinic-polycytidylic acid (PIC) induces hippocampal hyperexcitability in mice. Here, we characterized this hippocampal response through a whole genome transcriptome analysis. Intraperitoneal injection of PIC resulted in temporal dysregulation of 625 genes in the hippoca...

journal_title：Journal of neuroimmunology

authors： Michalovicz LT,Lally B,Konat GW

更新日期：2015-08-15 00:00:00

abstract：:Transplantation of a pituitary graft under the kidney capsule and the resulting elevation of serum prolactin enhances the primary humoral antibody response to sheep red blood cells. Enhancement of the response is not due to marked changes in the percentage of T-cells and their subsets, B-cells, or the number of nuclea...

journal_title：Journal of neuroimmunology

authors： Cross RJ,Campbell JL,Roszman TL

更新日期：1989-11-01 00:00:00

abstract：:Traumatic optic neuropathy (TON) is associated with apoptosis of retinal ganglion cells. Local productions of reactive oxygen species and inflammatory mediators from activated microglial cells have been hypothesized to underlie apoptotic processes. We previously demonstrated that the anti-inflammatory effect of adenos...

journal_title：Journal of neuroimmunology

authors： Ahmad S,Elsherbiny NM,Bhatia K,Elsherbini AM,Fulzele S,Liou GI

更新日期：2014-12-15 00:00:00

abstract：:Following inflammation or infection, cytokines are released in the blood. Besides their effect on the immune system, cytokines can also act in the brain to modulate our behaviors, inducing for example anorexia when produced in large amount. This review focuses on our current knowledge on how cytokines can influence th...

journal_title：Journal of neuroimmunology

authors： Guyon A,Massa F,Rovère C,Nahon JL

更新日期：2008-07-31 00:00:00

abstract：:Alpha-melanocyte-stimulating hormone (alpha-MSH) is an endogenous neuroimmunomodulatory peptide that can inhibit a broad range of inflammatory mediators known to be involved in the pathophysiology of bacterial meningitis. We evaluated the effect of alpha-MSH in a rat model of pneumococcal meningitis. Rats were intraci...

journal_title：Journal of neuroimmunology

authors： Kastenbauer S,Koedel U,Brzoska T,Luger TA,Pfister HW

更新日期：2001-05-01 00:00:00

abstract：:Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G) has recently been identified as a potent antiviral protein. Here, we examined the expression and regulation of APOBEC3G in human brain tissues and the cells of central nervous system (CNS). Similar to the immune cells, human brain tissue an...

journal_title：Journal of neuroimmunology

authors： Wang YJ,Wang X,Zhang H,Zhou L,Liu S,Kolson DL,Song L,Ye L,Ho WZ

更新日期：2009-01-03 00:00:00

abstract：:Unfractionated cytokines have been shown to induce in vitro proliferation of neonatal rat Schwann cells but the nature of the mitogen(s) is not known. A mixture of rabbit antibodies specific for recombinant interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) inhibited Schwann cell proliferation induced...

journal_title：Journal of neuroimmunology

authors： Lisak RP,Bealmear B

更新日期：1991-02-01 00:00:00

abstract：:Cytokines such as interleukin-1 (IL-1) are thought to contribute to the inflammatory response associated with autoimmune diseases like multiple sclerosis. We assessed the role of IL-1 in an animal model of MS, experimental allergic encephalomyelitis (EAE), by testing the effects of treatment with an IL-1 receptor anta...

journal_title：Journal of neuroimmunology

authors： Martin D,Near SL

更新日期：1995-09-01 00:00:00

abstract：:Indirect immunofluorescence and cell-type-specific markers were used to determine whether antibodies directed against specific neural cell types were present in patients with Alzheimer's disease (AD), other neurological diseases (OND) and normal controls. Sera and cerebrospinal fluid (CSF) were tested on either frozen...

journal_title：Journal of neuroimmunology

authors： Watts H,Kennedy PG,Thomas M

更新日期：1981-03-01 00:00:00

abstract：:T cell lines were selected from basic protein (BP)-immunized SJL/J mice using synthetic peptides encompassing the major SJL/J encephalitogenic determinant. Synthetic peptide-derived T cell lines proliferated in response to BP, the 89-169 peptidase fragment of BP and the synthetic peptides, pM87-99, pM90-99 and pM91-99...

journal_title：Journal of neuroimmunology

authors： Bourdette DN,Vandenbark AA,Hashim G,Whitham RH,Offner H

更新日期：1989-05-01 00:00:00

abstract：:Peripheral blood T cells were isolated from chronic progressive multiple sclerosis patients using a stepwise protocol of density gradient centrifugation, erythrocyte rosetting and adherent cell depletion, after which T cells were cultured with no added stimulus. These cultures exhibited as much as 10-fold higher 'back...

journal_title：Journal of neuroimmunology

authors： Kamin-Lewis RM,Karasanyi N,Koski CL,Lewis GK

更新日期：1994-09-01 00:00:00

abstract：:The subunit composition of acetylcholine receptor-like protein(s) (AChR-LP) expressed by normal thymus was investigated. In skeletal muscle, the AChR exists in two forms, an embryonic form which contains the gamma-subunit and an adult form where the gamma-subunit is substituted by a different, homologous subunit calle...

journal_title：Journal of neuroimmunology

authors： Nelson S,Conti-Tronconi BM

更新日期：1990-09-01 00:00:00

abstract：:A reciprocally permissive interaction occurs between cellular responses elicited by the pleiotropic cytokine tumor necrosis factor-alpha (TNF) and alpha(2)-adrenergic receptor activation, such that each may adapt in response to modifications in the other's effects. Changes in presynaptic adrenergic sensitivity as well...

journal_title：Journal of neuroimmunology

authors： Nickola TJ,Ignatowski TA,Spengler RN

更新日期：2000-07-10 00:00:00

abstract：:Multiple sclerosis (MS) patients make antibodies to heterogeneous nuclear ribonuclear protein A1 (hnRNP-A1), a nucleocytoplasmic protein. We hypothesized this autoimmune reaction might contribute to neurodegeneration. Antibodies from MS patients reacted with hnRNP-A1-'M9', its nuclear translocation sequence. Transfect...

journal_title：Journal of neuroimmunology

authors： Lee S,Xu L,Shin Y,Gardner L,Hartzes A,Dohan FC,Raine C,Homayouni R,Levin MC

更新日期：2011-06-01 00:00:00

abstract：:Among the death ligands of the tumor necrosis factor/nerve growth factor (TNF/NGF) superfamily, TNF-related apoptosis-inducing ligand (TRAIL) is considered to play a unique role due to its binding to both apoptosis-inducing and -blocking membranous receptors, apoptosis-independent effects and distinct species differen...

journal_title：Journal of neuroimmunology

authors： Dörr J,Waiczies S,Wendling U,Seeger B,Zipp F

更新日期：2002-01-01 00:00:00

abstract：:Fas (CD95) and Fas ligand (FasL, CD95L) have been implicated to be involved in the acute inflammatory response by attracting neutrophils and regulating their survival. Increased levels of soluble Fas and FasL are found in cerebrospinal fluid (CSF) samples of patients with bacterial meningitis but not in controls. Func...

journal_title：Journal of neuroimmunology

authors： Paul R,Angele B,Sporer B,Pfister HW,Koedel U

更新日期：2004-07-01 00:00:00

abstract：:Substance P (SP) can produce cytokine-like responses by astrocytes and mononuclear cells. In an effort to identify neurokinin-1-receptors (NK1-R), an antibody to NK1-R was generated by using a linear peptide sequence from the deduced third extracellular region (ECR) corresponding to the seven transmembrane rat brain N...

journal_title：Journal of neuroimmunology

authors： van Ginkel FW,Pascual DW

更新日期：1996-06-01 00:00:00

abstract：:We examined the effect of gallium (Ga) nitrate on the development of the development of experimental autoimmune encephalomyelitis (EAE). Weekly subcutaneous injections of 10-30 mg/kg prevented clinical signs as well as histopathological changes of EAE. The optimal timing of a single injection of Ga was 6 days after in...

journal_title：Journal of neuroimmunology

authors： Whitacre C,Apseloff G,Cox K,Matkovic V,Jewell S,Gerber N

更新日期：1992-07-01 00:00:00

abstract：:Matrix metalloproteinase 9 (MMP9) plays an important role in the pathogenesis of multiple sclerosis (MS). However, the impact of genetic variants affecting MMP9 on MS susceptibility is still in debate. We could not detect an association of MMP9 SNPs with MS on a genome-wide significance level by SNP genotyping, follow...

journal_title：Journal of neuroimmunology

authors： Nischwitz S,Wolf C,Andlauer TF,Czamara D,Zettl UK,Rieckmann P,Buck D,Ising M,Bettecken T,Mueller-Myhsok B,Weber F

更新日期：2015-02-15 00:00:00

abstract：:Although it is generally accepted that pro-inflammatory cytokines produced by cells of the central nervous system play important roles in the communication between the central nervous system and the immune system during sepsis, it is not clear whether these cytokines are produced in the brain under subseptic condition...

journal_title：Journal of neuroimmunology

authors： Quan N,Stern EL,Whiteside MB,Herkenham M

更新日期：1999-01-01 00:00:00

abstract：:In this study we evaluated the percentages of CD3(-)CD56(bright), CD3(-)CD56(dim), CD3(-)CD56(bright)perforin(+) and CD3(-)CD56(dim)perforin(+) Natural Killer (NK) cells in peripheral blood from untreated secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) patients and age and sex matched h...

journal_title：Journal of neuroimmunology

authors： Plantone D,Marti A,Frisullo G,Iorio R,Damato V,Nociti V,Patanella AK,Bianco A,Mirabella M,Batocchi AP

更新日期：2013-12-15 00:00:00

abstract：:Mechanism-oriented studies of EAE rely mostly on gene-modified mice on the C57BL/6 background. Here we report that MP4-induced EAE displays characteristic differences in CNS pathology as compared to MOG peptide 35-55-elicited disease. While in the latter, the topology of CNS infiltration remained unchanged throughout ...

journal_title：Journal of neuroimmunology

authors： Kuerten S,Kostova-Bales DA,Frenzel LP,Tigno JT,Tary-Lehmann M,Angelov DN,Lehmann PV

更新日期：2007-09-01 00:00:00

abstract：:A range of cell-specific markers have been employed with immunocytochemical methods to characterise and quantitate the cell types present in mixed brain cell cultures derived from dissociated 1-2-day post-natal rat cerebral hemispheres and grown in the presence of FCS. Protoplasmic astrocytes (GFAP+, A2B5-) were the m...

journal_title：Journal of neuroimmunology

authors： Walker AG,Chapman J,Bruce CB,Rumsby MG

更新日期：1984-11-01 00:00:00