Abstract:
:Multiple sclerosis (MS) patients make antibodies to heterogeneous nuclear ribonuclear protein A1 (hnRNP-A1), a nucleocytoplasmic protein. We hypothesized this autoimmune reaction might contribute to neurodegeneration. Antibodies from MS patients reacted with hnRNP-A1-'M9', its nuclear translocation sequence. Transfection of anti-M9 antibodies into neurons resulted in neuronal injury and changes in transcripts related to hnRNP-A1 function. Importantly, RNA levels for the spinal paraplegia genes (SPGs) decreased. Changes in SPG RNA levels were confirmed in neurons purified from MS brains. Also, we show molecular interactions between spastin (the encoded protein of SPG4) and hnRNP-A1. These data suggest a link between autoimmunity, clinical phenotype and neurodegeneration in MS.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Lee S,Xu L,Shin Y,Gardner L,Hartzes A,Dohan FC,Raine C,Homayouni R,Levin MCdoi
10.1016/j.jneuroim.2011.02.007subject
Has Abstractpub_date
2011-06-01 00:00:00pages
56-69issue
1-2eissn
0165-5728issn
1872-8421pii
S0165-5728(11)00031-2journal_volume
235pub_type
杂志文章abstract::The involvement of the immune system has been hypothesized in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study a significantly higher level of TNF-alpha and its soluble receptors, TNF-R1 and TNF-R2, has been found in plasma of patients affected by the sporadic form of ALS compared to normal subje...
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journal_title:Journal of neuroimmunology
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2007.04.008
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