B1 cells are unaffected by immune modulatory treatment in remitting-relapsing multiple sclerosis patients.


:In this study we aimed to investigate whether treatment with an immune modulatory drug had an effect on the distribution of B cell subpopulations in patients with remitting-relapsing multiple sclerosis (RRMS). We investigated the first-line drugs glatiramer acetate, interferon-β and natalizumab. Our data show that the frequency of the CD27(+)CD43(+) B1 cell subset was significantly diminished in RRMS patients compared to healthy subjects and that this subset was unaffected by treatment. Regardless of their true nature, we believe that these cells are part of the autoimmune disease pattern.


J Neuroimmunol


Rovituso D,Heller S,Schroeter M,Kleinschnitz C,Kuerten S




Has Abstract


2014-07-15 00:00:00














  • Identification and functional characterization of a highly polymorphic region in the human TRAIL promoter in multiple sclerosis.

    abstract::TNF-related apoptosis-inducing ligand (TRAIL) is not only involved in cell death but also in other immunoregulatory mechanisms. So far, the regulation of the TRAIL pathway in physiologic and pathologic conditions remains unclear. Due to the implication in brain damage and the elevated expression in peripheral immune c...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Weber A,Wandinger KP,Mueller W,Aktas O,Wengert O,Grundström E,Ehrlich S,Windemuth C,Kuhlmann T,Wienker T,Brück W,Zipp F

    更新日期:2004-04-01 00:00:00

  • Sex hormone-dependent attenuation of EAE in a transgenic mouse with astrocytic expression of the RNA regulator HuR.

    abstract::In experimental autoimmune encephalomyelitis (EAE) and other neurodegenerative diseases, astrocytes play an important role in promoting or attenuating the inflammatory response through induction of different cytokines and growth factors. HuR plays a major role in regulating many of these factors by modulating RNA stab...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Wheeler C,Nabors LB,Barnum S,Yang X,Hu X,Schoeb TR,Chen D,Ardelt AA,King PH

    更新日期:2012-05-15 00:00:00

  • Pattern recognition receptor mRNA expression and cytokine and granzyme levels in HIV infected individuals with neurotuberculosis.

    abstract::Neurotuberculosis is one of the commonest HIV-associated opportunistic infections (OI) of the CNS. Cross-talk between HIV, Mycobacterium tuberculosis and host immune responses may alter expression of pattern recognition receptors (PRRs), thereby affecting cytokine profiles and functional responses. We examined PRR mRN...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Rao D,Vasanthapuram R,Satishchandra P,Desai A

    更新日期:2018-05-15 00:00:00

  • A chemiluminescence assay to detect antibodies to brain surface antigens in human sera.

    abstract::A chemiluminescence assay was developed based on the interaction between antibodies binding to the surface of living brain cells in culture and macrophages. Such interaction leads to production of reactive oxygen radicals which can be measured by a chemiluminescence assay. This assay was used to detect anti brain anti...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Brügger M,Dayrell-Hart E,Meier C,Vandevelde M,Zurbriggen A

    更新日期:1994-01-01 00:00:00

  • Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta.

    abstract::M1 and M2 are the extremes of the differentiation spectrum of activated macrophages. Since microglia are members of the same cell lineage, we have characterized their transcription profile and their phagocytic activity under different conditions. LPS or IFN-gamma induce a M1-like phenotype, while IL-10 or IL-4 differe...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Michelucci A,Heurtaux T,Grandbarbe L,Morga E,Heuschling P

    更新日期:2009-05-29 00:00:00

  • Effect of rhTNF-alpha injection into rat sciatic nerve.

    abstract::To assess whether TNF-alpha causes inflammatory demyelination or axonal degeneration, we injected into rat sciatic nerve saline, 100 U and 1000 U of rhTNF-alpha and studied the electrophysiological and pathological effects. At day 1 electrophysiology showed a slight reduction of proximal compound muscle action potenti...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Uncini A,Di Muzio A,Di Guglielmo G,De Angelis MV,De Luca G,Lugaresi A,Gambi D

    更新日期:1999-02-01 00:00:00

  • A novel protective model against experimental allergic encephalomyelitis in mice expressing a transgenic TCR-specific for myelin oligodendrocyte glycoprotein.

    abstract::Myelin oligodendrocyte glycoprotein (MOG) is an important autoantigen in multiple sclerosis and in experimental autoimmune encephalomyelitis (EAE). We generated a T cell receptor (TCR) transgenic (Tg) mouse expressing a TCR derived from an encephalitogenic T cell clone specific for MOG(35-55). This mouse failed to dev...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Mendel I,Natarajan K,Ben-Nun A,Shevach EM

    更新日期:2004-04-01 00:00:00

  • Effects of beta-IFN-1b treatment in MS patients on adhesion between PBMNCs, HUVECs and MS-HBECs: an in vivo and in vitro study.

    abstract::The in vivo effects on the expression of adhesion molecules and on the adhesion between mononuclear cells and multiple sclerosis human brain endothelial cells (MS-HBECs) were investigated at the beginning of beta-IFN-1b treatment of MS patients. MS-HBECs were isolated from a surgical specimen obtained from an MS patie...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Corsini E,Gelati M,Dufour A,Massa G,Nespolo A,Ciusani E,Milanese C,La Mantia L,Salmaggi A

    更新日期:1997-10-01 00:00:00

  • Anadamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosis.

    abstract::This study examined the immunoregulatory effects of anadamide, the recently identified first endogenous cannabinoid receptor ligand. Anadamide caused dose-dependent inhibition of mitogen-induced T and B lymphocyte proliferation. Its potency was 3- and 10-fold less than that of the synthetic cannabinoids delta 8-tetrah...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Schwarz H,Blanco FJ,Lotz M

    更新日期:1994-11-01 00:00:00

  • The effect of methylprednisolone on lymphocyte phenotype and function in patients with multiple sclerosis.

    abstract::The extent to which symptomatic improvement in patients with multiple sclerosis treated with intravenous methylprednisolone depends on immunological actions of corticosteroids is unknown. In this study the effect of methylprednisolone on circulating T and B cell function has been assessed in vitro and in vivo. Low mol...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Kirk P,Compston A

    更新日期:1990-01-01 00:00:00

  • Omega-3 polyunsaturated fatty acids ameliorate neuroinflammation and mitigate ischemic stroke damage through interactions with astrocytes and microglia.

    abstract::Omega-3 polyunsaturated fatty acids (PUFA n3) provide neuroprotection due to their anti-inflammatory and anti-apoptotic properties as well as their regulatory function on growth factors and neuronal plasticity. These qualities enable PUFA n3 to ameliorate stroke outcome and limit neuronal damage. Young adult male rats...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Zendedel A,Habib P,Dang J,Lammerding L,Hoffmann S,Beyer C,Slowik A

    更新日期:2015-01-15 00:00:00

  • Features of skin-coincubated macrophages that promote recovery from spinal cord injury.

    abstract::Uncontrolled inflammation is considered to exacerbate the neuronal loss that follows spinal cord trauma. However, controlled inflammation response appears to be beneficial. Skin-coincubated macrophages injected into contused spinal cord of rats resulted in improved motor recovery and reduced spinal cyst formation. The...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Bomstein Y,Marder JB,Vitner K,Smirnov I,Lisaey G,Butovsky O,Fulga V,Yoles E

    更新日期:2003-09-01 00:00:00

  • Inhibition of Ras attenuates the course of experimental autoimmune neuritis.

    abstract::EAN induced in Lewis rats by immunization with peripheral bovine myelin was treated by the Ras inhibitor farnesylthiosalicylate (FTS). Treatment from day 0 with FTS (5 mg/kg intraperitoneally twice daily) attenuated peak clinical scores (mean+/-S.E., 2.5+/-0.5 compared to 4.1+/-0.5 in saline treated controls, p=0.018,...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Kafri M,Kloog Y,Korczyn AD,Ferdman-Aronovich R,Drory V,Katzav A,Wirguin I,Chapman J

    更新日期:2005-11-01 00:00:00

  • A transgenic mouse model to assess the interaction of cytotoxic T lymphocytes with virally infected, class I MHC-expressing astrocytes.

    abstract::Astrocytes provide crucial support for neurons and their impairment by viruses or their interactions with anti-viral or autoimmune responses could contribute to neurological disease. We have developed a transgenic mouse model to assess lymphocyte-astrocyte interactions. The major histocompatibility complex (MHC) class...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Rall GF,Mucke L,Nerenberg M,Oldstone MB

    更新日期:1994-06-01 00:00:00

  • Specificity of human IgM monoclonal antibodies from patients with peripheral neuropathy.

    abstract::Some patients with peripheral neuropathy and gammopathy have IgM monoclonal antibodies that react with the myelin-associated glycoprotein (MAG), some 20-26 kDa glycoproteins present only in the peripheral nervous system (PNS), and some acidic glycolipids that are also PNS-specific. This communication describes an inve...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: O'Shannessy DJ,Ilyas AA,Dalakas MC,Mendell JR,Quarles RH

    更新日期:1986-04-01 00:00:00

  • Immune system aberrations in postpartum psychosis: An immunophenotyping study from a tertiary care neuropsychiatric hospital in India.

    abstract::Postpartum psychosis (PP) is associated with significant morbidity to both mother and infant. Immune system dysregulation during PP is reported in recent studies. This study attempted to determine immune signatures associated with first-onset PP by flow cytometry. Peripheral blood showed decreased naive CD4 and CD8 T ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Kumar MM,Venkataswamy MM,Sathyanarayanan G,Thippeswamy H,Chandra PS,Mani RS

    更新日期:2017-09-15 00:00:00

  • Activated microglial cells acquire an immature dendritic cell phenotype and may terminate the immune response in an acute model of EAE.

    abstract::Antigen presentation, a key mechanism in immune responses, involves two main signals: the first is provided by the engagement of a major histocompatibility complex (MHC), class I or class II, with their TCR receptor in lymphocytes, whereas the second demands the participation of different co-stimulatory molecules, suc...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Almolda B,González B,Castellano B

    更新日期:2010-06-01 00:00:00

  • The involvement of neuroinflammation and necroptosis in the hippocampus during vascular dementia.

    abstract::The prevalence of vascular dementia is increasing at an alarming rate. The Confirmation of the clinical diagnosis of vascular dementia depends on post-mortem examination of the brain. In our study, we investigated the vascular disease and neuroinflammation during vascular dementia. Our results showed a β-amyloid depos...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Belkhelfa M,Beder N,Mouhoub D,Amri M,Hayet R,Tighilt N,Bakheti S,Laimouche S,Azzouz D,Belhadj R,Touil-Boukoffa C

    更新日期:2018-07-15 00:00:00

  • IFN-gamma up-regulation of IL-12 beta 2 receptor is associated with experimental autoimmune uveitis susceptible B10.A mice, but not in EAU resistant BALB/c mice.

    abstract::IFN-gamma production is a hallmark of Th1 response, and IFN-gamma has multiple roles in Th1 development, depending on the experimental conditions. In this study, the correlation between IFN-gamma and interleukin 12 receptor beta2 (IL-12R beta 2) expression was investigated in experimental autoimmune uveitis (EAU) susc...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Wu Y,Lin Y,Hou W,Wang Y,Sun B

    更新日期:2003-04-01 00:00:00

  • Interferon-γ potentiates GABAA receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons.

    abstract::The neural transmission and plasticity can be differentially modulated by various elements of the immune system. Interferon-γ (IFN-γ) is a "pro-inflammatory" cytokine mainly produced by T lymphocytes, activates its corresponding receptor and plays important roles under both homeostatic and inflammatory conditions. How...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Flood L,Korol SV,Ekselius L,Birnir B,Jin Z

    更新日期:2019-12-15 00:00:00

  • Gelsolin decreases actin toxicity and inflammation in murine multiple sclerosis.

    abstract::Gelsolin is the fourth most abundant protein in the body and its depletion in the blood has been found in multiple sclerosis (MS) patients. How gelsolin affects the MS brain has not been studied. We found that while the secreted form of gelsolin (pGSN) decreased in the blood of experimental autoimmune encephalomyeliti...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Li-ChunHsieh K,Schob S,Zeller MW,Pulli B,Ali M,Wang C,Chiou TT,Tsang YM,Lee PS,Stossel TP,Chen JW

    更新日期:2015-10-15 00:00:00

  • G-CSF enhances the adhesion of encephalitogenic T cells to extracellular matrix components: a possible mechanism for exacerbation of multiple sclerosis.

    abstract::Autologous stem cell transplantation is being considered as treatment of severe refractory autoimmune disorders, including MS. Stem cell mobilization is achieved with granulocyte-colony stimulating factor (G-CSF), however, G-CSF administration resulted in cases of worsened clinical MS status. We studied autoreactive T...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Snir O,Lavie G,Achiron A,Bank I,Ben-Aharon T,Sredni B,Cohen IR,Mandel M

    更新日期:2006-03-01 00:00:00

  • Isolated opsoclonus heralding neuromyelitis optica spectrum disorder.

    abstract::Opsoclonus is an ocular motility disorder characterized by spontaneous, arrhythmic conjugate saccades of varying amplitude occurring in all directions of gaze without normal intersaccadic interval. Etiological spectrum of opsoclonus encompasses paraneoplastic and neoplastic conditions, infectious and para-infectious e...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Ghosh R,Dubey S,Ray BK,Purkait S,Pandit A,Benito-León J

    更新日期:2020-11-15 00:00:00

  • Neuroprotection and enhanced neurogenesis by extract from the tropical plant Knema laurina after inflammatory damage in living brain tissue.

    abstract::Inflammatory reactions in the CNS, resulting from a loss of control and involving a network of non-neuronal and neuronal cells, are major contributors to the onset and progress of several major neurodegenerative diseases. Therapeutic strategies should therefore keep or restore the well-controlled and finely-tuned bala...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Häke I,Schönenberger S,Neumann J,Franke K,Paulsen-Merker K,Reymann K,Ismail G,Bin Din L,Said IM,Latiff A,Wessjohann L,Zipp F,Ullrich O

    更新日期:2009-01-03 00:00:00

  • Elevated cerebrospinal fluid CD4+/CD8+ T cell ratio in myasthenia gravis.

    abstract::The proportions of CD2+, CD4+ and CD8+ lymphocytes were determined with the 3-layer indirect immunoperoxidase technique in the cerebrospinal fluid (CSF) of 31 patients with myasthenia gravis (MG) and 21 control subjects without autoimmune or central nervous system (CNS) diseases. None of the MG patients were using imm...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Müller KM,Taskinen E,Iivanainen M

    更新日期:1990-12-01 00:00:00

  • "Allograft-inflammatory-factor-1 is upregulated in microglial cells in human cerebral infarctions".

    abstract::Allograft inflammatory factor-1 (AIF-1) is a 17-kDa-peptide identified in rat cardiac allografts undergoing chronic rejection and in activated microglial cells in inflammatory autoimune disease of the CNS. We have investigated the expression of AIF-1 in 18 autopsy cases of human focal cerebral infarction. AIF-1-positi...

    journal_title:Journal of neuroimmunology

    pub_type: 更正并重新发布的文章,杂志文章


    authors: Postler E,Rimner A,Beschorner R,Schluesener HJ,Meyermann R

    更新日期:2000-08-01 00:00:00

  • Clinical and MRI correlates of autoreactive antibodies in multiple sclerosis patients.

    abstract:BACKGROUND:Autoreactive antibodies (ARAB) occur more frequently in patients with multiple sclerosis (MS) than in general population and the presence of these antibodies often causes uncertainty regarding the disease course, response to therapy and the diagnosis of MS. METHODS:Retrospective analyses of the ARAB, clinic...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Garg N,Zivadinov R,Ramanathan M,Vasiliu I,Locke J,Watts K,Lema J,Rajeswary J,Munschauer FE,Ambrus J Jr,Weinstock-Guttman B

    更新日期:2007-07-01 00:00:00

  • Expression and regulation of antiviral protein APOBEC3G in human neuronal cells.

    abstract::Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G) has recently been identified as a potent antiviral protein. Here, we examined the expression and regulation of APOBEC3G in human brain tissues and the cells of central nervous system (CNS). Similar to the immune cells, human brain tissue an...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Wang YJ,Wang X,Zhang H,Zhou L,Liu S,Kolson DL,Song L,Ye L,Ho WZ

    更新日期:2009-01-03 00:00:00

  • Caveolin-3 is aberrantly expressed in skeletal muscle cells in myasthenia gravis.

    abstract::Caveolin-3 is a muscle-specific membrane protein that localizes to the sarcolemma and T-tubule system. Caveolin-3 is needed for muscle repair and skeletal muscle development. The objective of this study was to compare caveolin-3 expression in myasthenia gravis (MG) and control muscles. Caveolin-3 was abnormally expres...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Iwasa K,Furukawa Y,Yoshikawa H,Yamada M

    更新日期:2016-12-15 00:00:00

  • Complementary strategies to elucidate T helper cell epitopes in myasthenia gravis.

    abstract::CD4(+) T cells specific for the acetylcholine receptor (AChR) are assumed to play an important role in pathogenesis of myasthenia gravis (MG). A large and diverse number of potential T cell epitopes have been reported for different experimental setups aiming at the identification of disease-relevant T cells in MG. Inv...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Jung C,Stoeckle C,Wiesmüller KH,Laub R,Emmrich F,Jung G,Melms A

    更新日期:2008-09-15 00:00:00