B1 cells are unaffected by immune modulatory treatment in remitting-relapsing multiple sclerosis patients.

Abstract:

:In this study we aimed to investigate whether treatment with an immune modulatory drug had an effect on the distribution of B cell subpopulations in patients with remitting-relapsing multiple sclerosis (RRMS). We investigated the first-line drugs glatiramer acetate, interferon-β and natalizumab. Our data show that the frequency of the CD27(+)CD43(+) B1 cell subset was significantly diminished in RRMS patients compared to healthy subjects and that this subset was unaffected by treatment. Regardless of their true nature, we believe that these cells are part of the autoimmune disease pattern.

journal_name

J Neuroimmunol

authors

Rovituso D,Heller S,Schroeter M,Kleinschnitz C,Kuerten S

doi

10.1016/j.jneuroim.2014.04.008

subject

Has Abstract

pub_date

2014-07-15 00:00:00

pages

86-90

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(14)00119-2

journal_volume

272

pub_type

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