Type 1 immune response in progressive multiple sclerosis.

abstract：:This study examined the immunoregulatory effects of anadamide, the recently identified first endogenous cannabinoid receptor ligand. Anadamide caused dose-dependent inhibition of mitogen-induced T and B lymphocyte proliferation. Its potency was 3- and 10-fold less than that of the synthetic cannabinoids delta 8-tetrah...

journal_title：Journal of neuroimmunology

authors： Schwarz H,Blanco FJ,Lotz M

更新日期：1994-11-01 00:00:00

abstract：:H-2 class I antigens, but not class II antigens, were detected on the surface of glial cells persistently infected with mouse hepatitis virus strain A59 (MHV-A59) as late as 90 days post-infection. Uninfected glial cells remained negative for H-2 class I and class II surface antigens. We have previously shown that con...

journal_title：Journal of neuroimmunology

authors： Lavi E,Suzumura A,Murray EM,Silberberg DH,Weiss SR

更新日期：1989-04-01 00:00:00

abstract：:Differences in the regulation of surface molecule expression and functional activity of microglia, the resident immune effector elements of the central nervous system (CNS), might give important insights into understanding the predilection sites of some diseases within the CNS. Therefore, canine microglial cells in re...

journal_title：Journal of neuroimmunology

authors： Ensinger EM,Boekhoff TM,Carlson R,Beineke A,Rohn K,Tipold A,Stein VM

更新日期：2010-10-08 00:00:00

abstract：:M1 and M2 are the extremes of the differentiation spectrum of activated macrophages. Since microglia are members of the same cell lineage, we have characterized their transcription profile and their phagocytic activity under different conditions. LPS or IFN-gamma induce a M1-like phenotype, while IL-10 or IL-4 differe...

journal_title：Journal of neuroimmunology

authors： Michelucci A,Heurtaux T,Grandbarbe L,Morga E,Heuschling P

更新日期：2009-05-29 00:00:00

abstract：:Longitudinal brain atrophy quantification is a critical efficacy measurement in multiple sclerosis (MS) clinical trials and the determination of No Evidence of Disease Activity (NEDA). Utilising fingolimod as a clinically validated therapy we evaluated the use of repeated brain tissue volume measures during chronic ex...

journal_title：Journal of neuroimmunology

authors： Smith PA,Schmid C,Zurbruegg S,Jivkov M,Doelemeyer A,Theil D,Dubost V,Beckmann N

更新日期：2018-05-15 00:00:00

abstract：:Fas (CD95) and Fas ligand (FasL, CD95L) have been implicated to be involved in the acute inflammatory response by attracting neutrophils and regulating their survival. Increased levels of soluble Fas and FasL are found in cerebrospinal fluid (CSF) samples of patients with bacterial meningitis but not in controls. Func...

journal_title：Journal of neuroimmunology

authors： Paul R,Angele B,Sporer B,Pfister HW,Koedel U

更新日期：2004-07-01 00:00:00

abstract：:To find out whether rhesus macaque peripheral blood mononuclear cells (PBMCs) express mRNA for 5-HT receptors, blood samples from normal healthy rhesus monkeys were used to isolate PBMCs by Ficoll-paque density gradient centrifugation. Total RNA was extracted from MT-2 cells, Hut-78 cells, naive or phytohemagglutinin ...

journal_title：Journal of neuroimmunology

authors： Yang GB,Qiu CL,Zhao H,Liu Q,Shao Y

更新日期：2006-09-01 00:00:00

abstract：:Among the death ligands of the tumor necrosis factor/nerve growth factor (TNF/NGF) superfamily, TNF-related apoptosis-inducing ligand (TRAIL) is considered to play a unique role due to its binding to both apoptosis-inducing and -blocking membranous receptors, apoptosis-independent effects and distinct species differen...

journal_title：Journal of neuroimmunology

authors： Dörr J,Waiczies S,Wendling U,Seeger B,Zipp F

更新日期：2002-01-01 00:00:00

abstract：:Inflammatory mediators are involved in the pathogenesis of focal ischemic brain damage. In this study we used quantitative reverse transcriptase-polymerase chain reaction to analyze the spatiotemporal pattern of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and inducible nitric oxide synthase ...

journal_title：Journal of neuroimmunology

authors： Jander S,Schroeter M,Stoll G

更新日期：2000-09-22 00:00:00

abstract：:Little is known about the involvement of cytokines in the pathogenesis of primary progressive (PP) multiple sclerosis (MS). We evaluated in this cross-sectional study whether IL-18, IL-12p35, IL-12p40, TNF-alpha, IFN-gamma, IL-10, IL-4, TGF-beta, IL-12Rbeta1, and IL-12Rbeta2 mRNA expression in unstimulated white blood...

journal_title：Journal of neuroimmunology

authors： van Boxel-Dezaire AH,Smits M,van Trigt-Hoff SC,Killestein J,van Houwelingen JC,Polman CH,Nagelkerken L

更新日期：2001-11-01 00:00:00

abstract：:In this study we describe for the first time the production of stable human B cell lines and clones that secrete IgM antibody specific for human myelin basic protein. The technique based on limiting dilutions of Epstein-Barr virus-transformed peripheral B cells from patients with multiple sclerosis, precluded the need...

journal_title：Journal of neuroimmunology

authors： Zhang JW,Lambrechts J,Heyligen H,Vandenbark AA,Raus JC

更新日期：1989-09-01 00:00:00

abstract：:In the present study, we investigated the therapeutic benefit of cornel iridoid glycoside (CIG), the main component extracted from Cornus officinalis, in experimental autoimmune encephalomyelitis (EAE) rats. CIG was intragastrically administered daily after EAE initiation for 20days and reduced disease severity, incid...

journal_title：Journal of neuroimmunology

authors： Yin L,Chen Y,Qu Z,Zhang L,Wang Q,Zhang Q,Li L

更新日期：2014-09-15 00:00:00

abstract：:Sudden hearing loss may occur in rare cases of relapsing-remitting multiple sclerosis (RRMS). There have also been reports of idiopathic sudden sensorineural hearing loss (SNHL) in patients with neuromyelitis optica spectrum disorders (NMOSD), but the frequency of such cases is unclear. We conducted a retrospective an...

journal_title：Journal of neuroimmunology

authors： Tanaka M,Tanaka K

更新日期：2016-09-15 00:00:00

abstract：:Traumatic brain injury can lead to locally destructive secondary events mediated by several inflammatory components. Following lateral fluid-percussion (FP) brain injury in rats, we examined cortical and hippocampal sections for neutrophil infiltration and accumulation of complement component C3. Neutrophil influx int...

journal_title：Journal of neuroimmunology

authors： Keeling KL,Hicks RR,Mahesh J,Billings BB,Kotwal GJ

更新日期：2000-06-01 00:00:00

abstract：:Humoral and cell-mediated immune responses of inbred BALB/c male mice were assayed for differential reactivities associated with behavioral sidedness, which was evaluated by spontaneous rotational behavior in a circular cage model system. Mice with left-turning preference had lower in vivo primary IgM and IgG anti-Key...

journal_title：Journal of neuroimmunology

authors： Kim D,Carlson JN,Seegal RF,Lawrence DA

更新日期：1999-01-01 00:00:00

abstract：:HLA-DR, Iba1 and CD68 are widely used microglia markers in human tissue. However, due to differences in gene regulation, they may identify different activation stages of microglia. Here, we directly compared the expression of HLA-DR, Iba1 and CD68 in microglia with different phenotypes, ranging from ramified to amoebo...

journal_title：Journal of neuroimmunology

authors： Hendrickx DAE,van Eden CG,Schuurman KG,Hamann J,Huitinga I

更新日期：2017-08-15 00:00:00

abstract：:CD4+CD25+ regulatory T cells (Treg) transform the HIV-1 infected macrophage from a neurotoxic to a neuroprotective phenotype. This was demonstrated previously in a murine model of HIV-1 encephalitis induced by intracranial injection of HIV-1/vesicular stomatitis virus-infected bone marrow macrophages. In this report, ...

journal_title：Journal of neuroimmunology

authors： Gong N,Liu J,Reynolds AD,Gorantla S,Mosley RL,Gendelman HE

更新日期：2011-01-01 00:00:00

abstract：:In this study we have analysed the expression of mRNA encoding the m1-m5 mAChR subtypes in human blood mononuclear cells and subpopulations of lymphocytes using reverse transcriptase-polymerase chain reaction (RT-PCR) technique. Total RNA was extracted from human blood mononuclear cells. T cells, monocytes. EB virus t...

journal_title：Journal of neuroimmunology

authors： Hellström-Lindahl E,Nordberg A

更新日期：1996-08-01 00:00:00

abstract：:Cell lines of autoimmune T-lymphocytes have been established in several neuroimmunological model diseases and also in a human neurological autoimmune disease, myasthenia gravis. These cell lines generally have the T helper/inducer phenotype and recognize autoantigen in the context of class II histocompatibility antige...

journal_title：Journal of neuroimmunology

authors： Hohlfeld R,Toyka KV

更新日期：1985-08-01 00:00:00

abstract：:Brain capillary endothelial cells are the component of blood brain barrier, and the first line of defense against viruses invading into brain. We demonstrate that treatment of hCMEC/D3 cells, a human brain capillary endothelial cell line, with a Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly...

journal_title：Journal of neuroimmunology

authors： Imaizumi T,Sassa N,Kawaguchi S,Matsumiya T,Yoshida H,Seya K,Shiratori T,Hirono K,Tanaka H

更新日期：2018-11-15 00:00:00

abstract：:We have recently demonstrated that ConA-induced suppressor cell function is defective in chronic inflammatory demyelinating polyneuropathy (CIDP). To assess whether this defect plays a role in disease activity and its reversal is important in recovery, we studied modifications of ConA-induced suppressor cell function ...

journal_title：Journal of neuroimmunology

authors： De Luca G,Lugaresi A,Iarlori C,Marzoli F,Di Iorio A,Gambi D,Uncini A

更新日期：1999-03-01 00:00:00

abstract：:Suppressors of cytokine signaling (SOCS) negatively regulate the immune response, primarily by interfering with the JAK/STAT pathway. We have developed a small peptide corresponding to the kinase inhibitory region (KIR) sequence of SOCS-1, SOCS1-KIR, which inhibits kinase activity by binding to the activation loop of ...

journal_title：Journal of neuroimmunology

authors： Jager LD,Dabelic R,Waiboci LW,Lau K,Haider MS,Ahmed CM,Larkin J 3rd,David S,Johnson HM

更新日期：2011-03-01 00:00:00

abstract：:Recent evidence emphasises a pivotal role for dendritic cells (DC) in the control of immunity by priming and tolerising T cells. DC capture and process antigens, express co-stimulatory molecules, migrate to lymphoid organs and secrete cytokines to initiate immune responses. In multiple sclerosis (MS), autoreactive T c...

journal_title：Journal of neuroimmunology

authors： Huang YM,Xiao BG,Ozenci V,Kouwenhoven M,Teleshova N,Fredrikson S,Link H

更新日期：1999-09-01 00:00:00

abstract：:In this study, we evaluated the role of the two functional HLA-DR heterodimers, DR2a (DR alpha paired with the beta chain encoded by DRB5*0101) and DR2b (DR alpha paired with the beta chain encoded by DRB1*1501), that are coexpressed in the multiple sclerosis (MS)-associated haplotype HLA-DR15 Dw2, in presenting myeli...

journal_title：Journal of neuroimmunology

authors： Vergelli M,Kalbus M,Rojo SC,Hemmer B,Kalbacher H,Tranquill L,Beck H,McFarland HF,De Mars R,Long EO,Martin R

更新日期：1997-08-01 00:00:00

abstract：:Two pairs of monozygotic twins, discordant for myasthenia gravis (MG) for more than 30 years, were studied regarding T cell and antibody reactivity against disease related autoantigens, the acetylcholine receptor, one idiotypic and one anti-idiotypic human monoclonal antibody. The healthy and myasthenic twins had very...

journal_title：Journal of neuroimmunology

authors： Kakoulidou M,Ahlberg R,Yi Q,Giscombe R,Pirskanen R,Lefvert AK

更新日期：2004-03-01 00:00:00

abstract：:We evaluated the association of the platelet-activating factor receptor (PAFR) gene polymorphism (A224D) with the susceptibility and severity of multiple sclerosis (MS) in a Japanese population. DNA was collected from 162 Japanese patients with clinically definite 'conventional' MS (MS) and 245 healthy controls. The m...

journal_title：Journal of neuroimmunology

authors： Osoegawa M,Miyagishi R,Ochi H,Nakamura I,Niino M,Kikuchi S,Murai H,Fukazawa T,Minohara M,Tashiro K,Kira J

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Autoreactive antibodies (ARAB) occur more frequently in patients with multiple sclerosis (MS) than in general population and the presence of these antibodies often causes uncertainty regarding the disease course, response to therapy and the diagnosis of MS. METHODS:Retrospective analyses of the ARAB, clinic...

journal_title：Journal of neuroimmunology

authors： Garg N,Zivadinov R,Ramanathan M,Vasiliu I,Locke J,Watts K,Lema J,Rajeswary J,Munschauer FE,Ambrus J Jr,Weinstock-Guttman B

更新日期：2007-07-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a disease model of multiple sclerosis (MS) that is characterized by remittance and relapse of the disease and autoimmune and demyelinating lesions in the central nervous system (CNS). To better understand the mechanism of disease relapse, we induced acute and chronic ...

journal_title：Journal of neuroimmunology

authors： Jee Y,Yoon WK,Okura Y,Tanuma N,Matsumoto Y

更新日期：2002-07-01 00:00:00

abstract：:Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare and treatable variant of CAA likely due to an autoimmune response directed toward beta-amyloid deposits. Cognitive and behavioral manifestations are the most common symptoms, followed by focal neurological signs, headache and seizures, associated with...

journal_title：Journal of neuroimmunology

authors： Poli L,De Giuli V,Piazza F,Volonghi I,Bigliardi G,Vallone S,Nichelli PF,Gasparotti R,Zini A,Padovani A,Pezzini A

更新日期：2020-01-15 00:00:00

abstract：:PI-2301 is an immunomodulator that could be an alternative therapy for MS. A placebo-controlled, multiple-ascending dose, double-blind study was performed in patients with secondary-progressive MS. Treatment was given subcutaneously once weekly for 8 weeks, followed by a 4-week open-label treatment period with active ...

journal_title：Journal of neuroimmunology

authors： Kovalchin J,Krieger J,Genova M,Collins K,Augustyniak M,Masci A,Hittinger T,Kuca B,Edan G,Braudeau C,Rimbert M,Patel U,Mascioli E,Zanelli E

更新日期：2010-08-25 00:00:00