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Myasthenia gravis. Identification of skeletal and heart muscle antigens not related to the acetylcholine receptor.

Abstract：

:Myasthenia gravis (MG) is a neuromuscular disease thought to have an autoimmune etiology. The acetylcholine receptor has been considered the primary site of antibody binding; however, other muscle components may be involved in the pathogenesis of myasthenia gravis. This study describes a hypertonic sucrose extract of skeletal muscle (Muscle-HSE) that reacts with antibodies in myasthenic sera. The active component in Muscle-HSE is not the acetylcholine receptor as demonstrated by the inability of this extract to bind [125I]alpha-bungarotoxin. Muscle-HSE does, however, contain two distinct antigenic components reactive with MG sera. One antigen reacted with 70% (14/20) of myasthenic sera in the passive hemagglutination assay. This antigen was detected in the HSE of both skeletal muscle and heart, and was unaffected by treatment with Triton X-100. The second antigen reacted with 10% (2/20) of MG sera in the complement fixation assay, was unique to skeletal muscle, and was inactivated by Triton X-100.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Mehl VS,Lang RW

doi

10.1016/0165-5728(84)90024-9

subject

Has Abstract

pub_date

1984-08-01 00:00:00

pages

347-60

issue

5

eissn

0165-5728

issn

1872-8421

pii

0165-5728(84)90024-9

journal_volume

6

pub_type

杂志文章

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