Phenotypes and alloantigen-presenting activity of individual clones of microglia derived from the mouse brain.

abstract：:To determine the contribution of vascular endothelial growth factor (VEGF) to cerebral edema formation in bacterial meningitis, we used a VEGF neutralizing antibody to block VEGF in rabbits, following induction of meningitis by intracisternal inoculation with 10(9) heat-killed pneumococci. At 8 h, cerebrospinal fluid ...

journal_title：Journal of neuroimmunology

authors： van der Flier M,Coenjaerts FE,Mwinzi PN,Rijkers E,Ruyken M,Scharringa J,Kimpen JL,Hoepelman AI,Geelen SP

更新日期：2005-03-01 00:00:00

abstract：:Antibody responses to myelin antigens were analysed in 15 patients who developed acute neuroparalytic accidents (ANPA) during post-exposure rabies vaccination using a rabies vaccine prepared on brain tissues and in 30 individuals who were uneventfully vaccinated. High titers (> or = 100) of IgG and IgM antibodies to G...

journal_title：Journal of neuroimmunology

authors： Laouini D,Kennou MF,Khoufi S,Dellagi K

更新日期：1998-11-02 00:00:00

abstract：:Human G-protein-coupled formyl peptide receptor-like 1 and its mouse homologue formyl peptide receptor 2 mediate the chemotactic activity of a variety of pathogen and host-derived peptides, including amyloid beta(42), a key causative factor in Alzheimer's disease (AD).Here, we found that polyinosine-polycytidylic acid...

journal_title：Journal of neuroimmunology

authors： Chen K,Huang J,Liu Y,Gong W,Cui Y,Wang JM

更新日期：2009-08-18 00:00:00

abstract：:NFS/N mice infected with neurotropic Cas-Br-M murine leukemia virus (MuLV) at 21 days of age were resistant to neurologic disease and demonstrated MuLV-specific cytotoxic T lymphocyte (CTL) activity in spleen cells after in vitro stimulation. NFS/N mice infected with Cas-Br-M MuLV at 2 days of age failed to generate a...

journal_title：Journal of neuroimmunology

authors： Robbins DS,Hoffman PM

更新日期：1991-01-01 00:00:00

abstract：:The interaction between lymphocytes and brain endothelium is a central pathogenetic event in CNS autoimmunity and, thus, represents an important focus of investigation. Chemokine binding through specific G protein-coupled receptors (GPCRs) on lymphocyte surface activates integrins and induces inside-out signaling and ...

journal_title：Journal of neuroimmunology

authors： Constantin G

更新日期：2008-07-31 00:00:00

abstract：:Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are common demyelinating disorders of the central nervous system. The etiology and pathogenesis of MS and NMOSD remain unclear. The pathogenesis of these two diseases involves a genetic predisposition as well as environmental factors. NMOSD som...

journal_title：Journal of neuroimmunology

authors： Liang H,Gao W,Liu X,Liu J,Mao X,Yang M,Long X,Zhou Y,Zhang Q,Zhu J,Wang S,Jin T

更新日期：2019-12-15 00:00:00

abstract：:Guinea pigs inoculated with bovine spinal cord ventral horn homogenate develop a syndrome termed experimental autoimmune gray matter disease (EAGMD) characterized by extremity weakness, bulbar signs, and a loss of lower and upper motoneurons. To provide evidence for the role of autoimmune mechanisms, we have administe...

journal_title：Journal of neuroimmunology

authors： Tajti J,Stefani E,Appel SH

更新日期：1991-11-01 00:00:00

abstract：:This study aimed to determine the seasonal impact on the clinical onset of inflammatory neurological diseases of the central nervous system by analyzing the onset month with information on clinical manifestations in Japanese patients. As a result, patients with anti-aquaporin-4 antibodies (AQP4-IgG)-positive neuromyel...

journal_title：Journal of neuroimmunology

authors： Akaishi T,Fujimori J,Takahashi T,Misu T,Takai Y,Nishiyama S,Kaneko K,Ogawa R,Abe M,Ishii T,Aoki M,Fujihara K,Nakashima I

更新日期：2020-12-15 00:00:00

abstract：:The Th1-like cytokines, interleukin 2 (IL-2), interferon gamma (IFN-gamma), and lymphotoxin alpha (LT-alpha) have been implicated in the immunopathogenesis of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), an animal model of immune mediated demyelination. These cytokines have been associate...

journal_title：Journal of neuroimmunology

authors： Calabresi PA,Fields NS,Farnon EC,Frank JA,Bash CN,Kawanashi T,Maloni H,Jacobson S,McFarland HF

更新日期：1998-05-15 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are proteases involved in extracellular matrix (ECM) remodeling, leukocyte infiltration into lesions and myelin degradation in the central nervous system (CNS) disease multiple sclerosis (MS). We have investigated whether MMP-12 (macrophage metalloelastase) is expressed in MS lesions a...

journal_title：Journal of neuroimmunology

authors： Vos CM,van Haastert ES,de Groot CJ,van der Valk P,de Vries HE

更新日期：2003-05-01 00:00:00

abstract：:We examined anti-complement C1q (C1q) autoantibody levels in serum and cerebrospinal fluid (CSF) samples of patients with neuromyelitis optica spectrum disorders (NMOSD). We analyzed the correlations between anti-C1q autoantibody levels and the clinical and other CSF characteristics of NMOSD. Serum and CSF anti-C1q au...

journal_title：Journal of neuroimmunology

authors： Yoshikura N,Kimura A,Hayashi Y,Inuzuka T

更新日期：2017-09-15 00:00:00

abstract：:The Lyme disease agent Borrelia garinii has been suggested to be neurotrop, preferentially affecting the nervous system. We compared the secretion of interferon-gamma in response to outer surface proteins from Borrelia garinii and Borrelia afzelii in 10 patients with neuroborreliosis. In cerebrospinal fluid, stimulati...

journal_title：Journal of neuroimmunology

authors： Ekerfelt C,Ernerudh J,Forsberg P,Bergström S

更新日期：1998-08-14 00:00:00

abstract：:Ketamine is a potent anti-depressive agent. Nitric oxide plays an essential role in neuronal transmission and cerebral blood flow and has been implicated in the pathophysiology of major depressive disorder as well as cardiovascular functioning. We investigated the effect of ketamine on eNOS expression in human A172 as...

journal_title：Journal of neuroimmunology

authors： Yuhas Y,Ashkenazi S,Berent E,Weizman A

更新日期：2017-04-15 00:00:00

abstract：:Cigarette smoking is the most prominent significant cause of death and morbidity. It is recognised as a risk factor for a number of immune mediated, inflammatory diseases including multiple sclerosis (MS). Here, we review the complex immunological effects of smoking on the immune system, which include enhancement of i...

journal_title：Journal of neuroimmunology

authors： Alrouji M,Manouchehrinia A,Gran B,Constantinescu CS

更新日期：2019-04-15 00:00:00

abstract：:An electroimmunoblotting technique was used with a monoclonal antibody to myelin basic protein (MBP) to assess demyelination in 3 defined regions of the spinal cord in rats with acute experimental autoimmune encephalomyelitis (EAE). A slight loss in MBP was detected only in the sacrococcygeal region of the spinal cord...

journal_title：Journal of neuroimmunology

authors： Kerlero de Rosbo N,Bernard CC,Simmons RD,Carnegie PR

更新日期：1985-10-01 00:00:00

abstract：:Only few reports are available on the epitope specificity of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in multiple sclerosis (MS). In the present study we provide a precise characterization of the epitope specificity of serum antibodies directed against the extracellular domain of MOG, including IgG, I...

journal_title：Journal of neuroimmunology

authors： Khalil M,Reindl M,Lutterotti A,Kuenz B,Ehling R,Gneiss C,Lackner P,Deisenhammer F,Berger T

更新日期：2006-05-01 00:00:00

abstract：:Indirect immunofluorescence and cell-type-specific markers were used to determine whether antibodies directed against specific neural cell types were present in patients with Alzheimer's disease (AD), other neurological diseases (OND) and normal controls. Sera and cerebrospinal fluid (CSF) were tested on either frozen...

journal_title：Journal of neuroimmunology

authors： Watts H,Kennedy PG,Thomas M

更新日期：1981-03-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a common animal model that has the same pathology and pathogenesis as multiple sclerosis (MS). Dendritic cells (DCs) exert an important role in central and peripheral tolerance. DCs not only drive T cell priming and differentiation via playing antigen presentation fun...

journal_title：Journal of neuroimmunology

authors： Cao Q,Zheng C,Xie Z,Liu L,Zhu J,Jin T

更新日期：2020-01-15 00:00:00

abstract：:Reactive oxygen species (ROS) produced by activated microglia are deleterious to neurons. In this study, we studied the effect of Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin (MnTMPyP), a superoxide dismutase/catalase mimetic, on the lipopolysaccharide (LPS)-induced degeneration of dopaminergic neurons in rat mesencep...

journal_title：Journal of neuroimmunology

authors： Wang T,Liu B,Qin L,Wilson B,Hong JS

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:It's hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of multiple sclerosis (MS). The aim of the present study was to assess the prevalence of small intestinal bacterial overgrowth (SIBO) in MS patients compared with sex and age matched controls without MS. METHODS:T...

journal_title：Journal of neuroimmunology

authors： Zhang Y,Liu G,Duan Y,Han X,Dong H,Geng J

更新日期：2016-12-15 00:00:00

abstract：:Multiple sclerosis (MS) is an immune-mediated demyelinating disease that could be triggered by a viral infection. Coronaviruses induce an MS-like disease in rodents, are neuroinvasive in humans and can infect primary cultures of human astrocytes and microglia. Infection of the human astrocytic cell line U-373MG by the...

journal_title：Journal of neuroimmunology

authors： Edwards JA,Denis F,Talbot PJ

更新日期：2000-08-01 00:00:00

abstract：:An altered peptide ligand (analog) of the encephalitogenic epitope of proteolipid protein residues 139-151 (p139-151) in which residues 144 and 147 are substituted with leucine and arginine, respectively (LR), protects from clinical but not histological experimental allergic encephalomyelitis (EAE). To understand in s...

journal_title：Journal of neuroimmunology

authors： Santambrogio L,Lees MB,Sobel RA

更新日期：1998-01-01 00:00:00

abstract：:In this study, we analysed the recall antigen-induced cytokine production by peripheral blood mononuclear cells (PBMC) from 31 patients with multiple sclerosis (MS) with a relapsing-remitting (rr) and a relapsing-progressive (rp) course and from 40 healthy controls. Cells were stimulated with purified protein derivati...

journal_title：Journal of neuroimmunology

authors： Barth H,Klein K,Börtlein A,Guseo A,Berg PA,Wiethölter H,Klein R

更新日期：2002-12-01 00:00:00

abstract：:Receptors for VIP in mouse peritoneal macrophages (MPM) were examined using [125I]labeled VIP as ligand. The receptor binding was rapid, reversible, saturable, specific, and dependent on time, pH, temperature and cell concentration. At 15 degrees C, the stoichiometric data suggested the presence of two classes of VIP ...

journal_title：Journal of neuroimmunology

authors： Calvo JR,Montilla ML,Guerrero JM,Segura JJ

更新日期：1994-02-01 00:00:00

abstract：:A B-cell activating factor of the tumor necrosis factor (TNF) family (BAFF) is an essential B-cell survival factor. Myasthenia gravis (MG) is one of the most typical antibody-mediated autoimmune disorders. To test whether serum BAFF levels are increased in MG patients, we compared the serum BAFF levels of 40 MG patien...

journal_title：Journal of neuroimmunology

authors： Kim JY,Yang Y,Moon JS,Lee EY,So SH,Lee HS,Park KD,Choi YC

更新日期：2008-08-13 00:00:00

abstract：:The pro-inflammatory cytokine IL-1β is known to play a role in several models of aging, neuroinflammation, and neurodegenerative diseases. Here, we document a detailed time- and age-dependent pattern of pro- and anti-inflammatory biomarkers following bilateral intrahippocampal injection of interleukin-1β. During the f...

journal_title：Journal of neuroimmunology

authors： Hopp SC,Royer S,Brothers HM,Kaercher RM,D'Angelo H,Bardou I,Wenk GL

更新日期：2014-02-15 00:00:00

abstract：:The aim of this study was to evaluate a possible role of soluble CD14 (sCD14) in multiple sclerosis (MS). We found that sCD14 serum levels measured by ELISA were higher in MS patients compared to neurological and healthy controls. Within the MS group sCD14 levels were increased in relapsing-remitting and secondary pro...

journal_title：Journal of neuroimmunology

authors： Lutterotti A,Kuenz B,Gredler V,Khalil M,Ehling R,Gneiss C,Egg R,Deisenhammer F,Berger T,Reindl M

更新日期：2006-12-01 00:00:00

abstract：:T cell lines were selected from basic protein (BP)-immunized SJL/J mice using synthetic peptides encompassing the major SJL/J encephalitogenic determinant. Synthetic peptide-derived T cell lines proliferated in response to BP, the 89-169 peptidase fragment of BP and the synthetic peptides, pM87-99, pM90-99 and pM91-99...

journal_title：Journal of neuroimmunology

authors： Bourdette DN,Vandenbark AA,Hashim G,Whitham RH,Offner H

更新日期：1989-05-01 00:00:00

abstract：:A cross-reactive idiotope (CRI) has been previously described on monoclonal antibodies (mAbs) specific for encephalitogenic peptides from myelin basic protein (MBP). The anti-CRI mAb, F25F7, binds an idiotope (Id) localized to the light chains of an anti-MBP peptide 1-9 mAb, denoted F23C6, and an anti-MBP peptide 80-8...

journal_title：Journal of neuroimmunology

authors： Maier CC,LeBoeuf RD,Zhou SR,Whitaker JN,Jarpe MA,Blalock JE

更新日期：1993-07-01 00:00:00

abstract：:Large-scale genome-wide association study (GWAS) datasets provide strong support for investigations of the mechanisms underlying multiple sclerosis (MS) by using pathway analysis methods. In our recent study, we conducted a three-stage pathway analysis of GWAS and expression datasets. After identifying 15 shared MS pa...

journal_title：Journal of neuroimmunology

authors： Liu G,Zhang F,Hu Y,Jiang Y,Gong Z,Liu S,Chen X,Jiang Q,Hao J

更新日期：2017-06-15 00:00:00