Cyclophosphamide alters the clinical and pathological expression of experimental autoimmune gray matter disease.

abstract：:Neuronal damage in Alzheimer's disease (AD) is thought to involve direct toxicity of beta-amyloid peptide (Abeta) and excitotoxicity involving NMDA receptors (NMDARs) and altered Ca(2+) dynamics. Inflammation agents produced by microglia or astrocytes and associated with senile plaques such as the cytokine interleukin...

journal_title：Journal of neuroimmunology

authors： Qiu Z,Gruol DL

更新日期：2003-06-01 00:00:00

abstract：:Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) is a well-characterized murine model of the chronic-progressive form of human multiple sclerosis (MS) characterized by the activation of myelin-specific autoreactive CD4 Th1 cells via epitope spreading. To gain an understanding of the po...

journal_title：Journal of neuroimmunology

authors： Mack CL,Vanderlugt-Castaneda CL,Neville KL,Miller SD

更新日期：2003-11-01 00:00:00

abstract：:Macrophage colony-stimulating factor (M-CSF) is a critical cytokine in the development of monocytic lineage and may have immunoregulatory properties. Here we show that peritoneal antigen presenting cells (APCs) treated with M-CSF produced decreased levels of proinflammatory cytokines IFN-gamma, TNF-alpha and IL-12. Th...

journal_title：Journal of neuroimmunology

authors： Guan Y,Yu S,Zhao Z,Ciric B,Zhang GX,Rostami A

更新日期：2007-12-01 00:00:00

abstract：:Multiple sclerosis (MS) is an inflammatory, demyelinating disease affecting the central nervous system. MS-associated variants have been reported at both HLA and non-HLA loci, the latter including chromosome 13q31-32 and the Glypican-5 and Glypican-6 genes. In order to further explore the 13q31-32 region in MS, we gen...

journal_title：Journal of neuroimmunology

authors： Lorentzen AR,Melum E,Ellinghaus E,Smestad C,Mero IL,Aarseth JH,Myhr KM,Celius EG,Lie BA,Karlsen TH,Franke A,Harbo HF

更新日期：2010-09-14 00:00:00

abstract：:In this study we have analysed the expression of mRNA encoding the m1-m5 mAChR subtypes in human blood mononuclear cells and subpopulations of lymphocytes using reverse transcriptase-polymerase chain reaction (RT-PCR) technique. Total RNA was extracted from human blood mononuclear cells. T cells, monocytes. EB virus t...

journal_title：Journal of neuroimmunology

authors： Hellström-Lindahl E,Nordberg A

更新日期：1996-08-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) limits mouse autoimmune neuroinflammation by promoting the development of tolerogenic dendritic cells (DCs). Given the role played by DCs in the establishment of immunological tolerance, agents that coerce DCs to adopt a protolerogenic function are currently under investigation for multi...

journal_title：Journal of neuroimmunology

authors： Molnarfi N,Benkhoucha M,Juillard C,Bjarnadóttir K,Lalive PH

更新日期：2014-02-15 00:00:00

abstract：:Based on gene expression data, we tested the P8A-CCL2 variant of the chemokine CCL2, able to interfere with the chemotactic properties of the parental molecule, in relapsing-remitting (RR)-EAE SJL. Only preventive treatment significantly delayed disease onset in a dose dependent manner. P8A-CCL2 administration, howeve...

journal_title：Journal of neuroimmunology

authors： Brini E,Ruffini F,Bergami A,Brambilla E,Dati G,Greco B,Cirillo R,Proudfoot AE,Comi G,Furlan R,Zaratin P,Martino G

更新日期：2009-04-30 00:00:00

abstract：BACKGROUND:Increased expression of monocyte chemoattractant protein type 1 (MCP-1) is associated with HIV CNS disease. This study evaluated the temporal relationships between MCP-1 expression and HIV replication in the CNS. METHODS:MCP-1 and HIV viral load (VL) were measured in serially obtained samples of plasma and ...

journal_title：Journal of neuroimmunology

authors： Monteiro de Almeida S,Letendre S,Zimmerman J,Lazzaretto D,McCutchan A,Ellis R

更新日期：2005-12-01 00:00:00

abstract：:We investigated whether the sensory neuropeptide, calcitonin gene-related peptide (CGRP), could be synthesised by human lymphocytes. Our results indicate that in activated B-cells, there is a strong expression of CGRP gene transcripts, which is almost absent in resting cells. Since B-cells autocrinally produce NGF, th...

journal_title：Journal of neuroimmunology

authors： Bracci-Laudiero L,Aloe L,Buanne P,Finn A,Stenfors C,Vigneti E,Theodorsson E,Lundeberg T

更新日期：2002-02-01 00:00:00

abstract：:In this study the effect of long-term selective sensory vs. sympathetic denervation was examined in the rat lung. Immunoreactivities for calcitonin gene-related peptide (CGRP) on the one hand and tyrosine hydroxylase (TH) on the other, were used as indexes to assess the changes in the two nerve systems. Following long...

journal_title：Journal of neuroimmunology

authors： Van Ranst L,Lauweryns JM

更新日期：1990-09-01 00:00:00

abstract：:The prevalence of vascular dementia is increasing at an alarming rate. The Confirmation of the clinical diagnosis of vascular dementia depends on post-mortem examination of the brain. In our study, we investigated the vascular disease and neuroinflammation during vascular dementia. Our results showed a β-amyloid depos...

journal_title：Journal of neuroimmunology

authors： Belkhelfa M,Beder N,Mouhoub D,Amri M,Hayet R,Tighilt N,Bakheti S,Laimouche S,Azzouz D,Belhadj R,Touil-Boukoffa C

更新日期：2018-07-15 00:00:00

abstract：:Intercellular adhesion molecule-1 (ICAM-1) is a cell surface glycoprotein which can be induced on astrocytes, the major glial cell of the central nervous system (CNS). In this study, we examined the effect of three proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and ...

journal_title：Journal of neuroimmunology

authors： Shrikant P,Chung IY,Ballestas ME,Benveniste EN

更新日期：1994-05-01 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) has been reported to be expressed in various inflammatory disorders including human T cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-I-infected T-cells expressed high levels of MMP-9 via viral transactivator Tax mediated act...

journal_title：Journal of neuroimmunology

authors： Kodama D,Saito M,Matsumoto W,Sabouri AH,Izumo S,Arimura K,Usuku K,Bangham CR,Osame M

更新日期：2004-11-01 00:00:00

abstract：:The relationship of the mouse nervous system specific band 1 protein to the putative high molecular weight component of the Na+ channel was investigated using antibody to band 1. Morphologic differentiation of cultured neuroblastoma cells has been reported to increase the quantity of the putative Na+ channel high mole...

journal_title：Journal of neuroimmunology

authors： Akeson R,Graham K

更新日期：1981-09-01 00:00:00

abstract：:We compared the expression of various interferon-gamma (IFN-gamma)-inducible mRNAs in primary rat astrocytes and microglia. Of 11 different mRNAs inducible by IFN-gamma in a macrophage cell line, RAW 264.7, only eight were induced in both types of glia, which included mRNAs encoding the transcriptional factors, IRF-1,...

journal_title：Journal of neuroimmunology

authors： Vanguri P

更新日期：1995-01-01 00:00:00

abstract：:Stiff person spectrum disorders (SPSD) are a broad group of immune-mediated disorders. Clinical presentations include classical stiff person syndrome (SPS), focal SPS, and progressive encephalomyelitis with rigidity and myoclonus (PERM). The most frequently associated antibodies are anti-GAD65, anti-GlyR, anti-amphiph...

journal_title：Journal of neuroimmunology

authors： Bernardo F,Rebordão L,Rêgo A,Machado S,Passos J,Costa C,Cruz S,Pinto AN,Santos M

更新日期：2020-04-15 00:00:00

abstract：:Insulin-like growth factor-2 (IGF-2) present in media conditioned by non-activated and interferon gamma (IFN gamma)-treated microglia reduces galactocerebroside(+) (GalC) oligodendrocyte apoptosis in cultures derived both from the CG4 cell line and primary rat cortices. Microglia-derived IGF-2 also acts in each cultur...

journal_title：Journal of neuroimmunology

authors： Nicholas RS,Stevens S,Wing MG,Compston DA

更新日期：2002-03-01 00:00:00

abstract：:Lewis rats were treated from day of birth with a rabbit anti-rat IgM antiserum. As adults these animals were found to have no detectable serum IgM and greatly reduced levels of IgG. They failed to respond to the B-cell mitogen LPS, or to make antibodies to sheep red blood cells (SRBC) or myelin basic protein (BP). The...

journal_title：Journal of neuroimmunology

authors： Willenborg DO,Prowse SJ

更新日期：1983-10-01 00:00:00

abstract：:The chemokine interleukin 8/CXCL8 induces the phosphorylation of the GluR1 subunit of the AMPA-type glutamate receptor in neurons and transfected HEK cells, on both serine 845 (S845) and 831 (S831) residues. We previously described that CXCL8 receptor CXCR2 and GluR1 co-precipitate and that GluR1/CXCR2 co-expression b...

journal_title：Journal of neuroimmunology

authors： Catalano M,Trettel F,Cipriani R,Lauro C,Sobrero F,Eusebi F,Limatola C

更新日期：2008-07-31 00:00:00

abstract：:The perpetuation of the inflammatory process in multiple sclerosis (MS) may arise from the failure to eliminate potentially pathogenic autoreactive lymphocytes by programmed cell death (apoptosis). Such impairment may be caused by multiple abnormalities of apoptosis regulatory proteins. In this study, we investigated ...

journal_title：Journal of neuroimmunology

authors： Sharief MK,Semra YK

更新日期：2001-10-01 00:00:00

abstract：:Human sera from patients with multiple sclerosis (MS) were tested using an enzyme-linked immunosorbent assay (ELISA) method on well plates coated with various dicarboxylic acid (C4 to C10) protein conjugates. Specific immunological binding was found with an azelaic acid (AzeA, C9) conjugate. The antibody titer was hig...

journal_title：Journal of neuroimmunology

authors： Daverat P,Geffard M,Orgogozo JM

更新日期：1989-04-01 00:00:00

abstract：:A systematic study of thymus homogenates and cell suspensions from 13 patients with myasthenia gravis (MG) of recent onset, and 6 non-myasthenic controls, has failed to detect or isolate virus by cell culture with 'rescue techniques', electron microscopy, or intracerebral inoculation into neonatal mice. These results ...

journal_title：Journal of neuroimmunology

authors： Klavinskis LS,Willcox HN,Richmond JE,Newsom-Davis J

更新日期：1986-06-01 00:00:00

abstract：:Traumatic brain injury triggers a cascade of events resulting in delayed edema, necrosis and impaired function. Harmful mediators are accumulating in the brain after injury and recently, the role of cytokines in the pathophysiology of brain injury has been suggested. We have developed an experimental model for closed ...

journal_title：Journal of neuroimmunology

authors： Shohami E,Gallily R,Mechoulam R,Bass R,Ben-Hur T

更新日期：1997-02-01 00:00:00

abstract：:Serum and CSF specimens from clinically healthy Brown Norway (BN) rats inoculated intracerebrally with corona virus JHM were analysed with respect to the state of the blood-brain barrier (BBB) and the intrathecal synthesis and isoelectric distribution of immunoglobulins (Ig). Increased CSF/serum ratios for Ig in the c...

journal_title：Journal of neuroimmunology

authors： Dörries R,Watanabe R,Wege H,ter Meulen V

更新日期：1987-04-01 00:00:00

abstract：:The effect of interleukin-17 (IL-17) on production of nitric oxide (NO) in rodent astrocytes was investigated. While IL-17 by itself did not induce NO production, it caused a dose-dependent enhancement of IFN-gamma-triggered NO synthesis in both mouse and rat primary astrocytes. In contrast, IL-17 was unable to stimul...

journal_title：Journal of neuroimmunology

authors： Trajkovic V,Stosic-Grujicic S,Samardzic T,Markovic M,Miljkovic D,Ramic Z,Mostarica Stojkovic M

更新日期：2001-10-01 00:00:00

abstract：:Active immunization with myelin basic protein (MBP) induces experimental allergic encephalomyelitis (EAE) in a variety of animal species, including rats and mice. We have previously described the ability of the newly described mouse lambda (lambda) variable (V) region V lambda x, to confer MBP reactivity to an Ab. In ...

journal_title：Journal of neuroimmunology

authors： Galin FS,Zhou SR,Whitaker JN,Blalock JE

更新日期：1996-10-01 00:00:00

abstract：:Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare and treatable variant of CAA likely due to an autoimmune response directed toward beta-amyloid deposits. Cognitive and behavioral manifestations are the most common symptoms, followed by focal neurological signs, headache and seizures, associated with...

journal_title：Journal of neuroimmunology

authors： Poli L,De Giuli V,Piazza F,Volonghi I,Bigliardi G,Vallone S,Nichelli PF,Gasparotti R,Zini A,Padovani A,Pezzini A

更新日期：2020-01-15 00:00:00

abstract：:Childhood opsoclonus-myoclonus syndrome (OMS) occurs idiopathic or, in association with a neuroblastoma, as a paraneoplastic syndrome. Since autoantibodies were identified in some patients, an autoimmune pathogenesis has been suspected. While the newly discovered B-cell activating factors BAFF and APRIL are involved i...

journal_title：Journal of neuroimmunology

authors： Fühlhuber V,Bick S,Kirsten A,Hahn A,Gerriets T,Tschernatsch M,Kaps M,Preissner KT,Blaes F,Altenkämper S

更新日期：2009-05-29 00:00:00

abstract：:Cellular adhesion molecules were initially defined as cell surface structures mediating cell-cell and cell-extracellular matrix (ECM) interactions. Adhesion molecules involved in immune responses have been classified into three families according to their structure: selectins, immunoglobulin (Ig) superfamily, and inte...

journal_title：Journal of neuroimmunology

authors： Lee SJ,Benveniste EN

更新日期：1999-08-03 00:00:00

abstract：:Immoderate immunoreaction of antigen-specific Th17 and Treg cell dysfunction play critical roles in the pathogenesis of multiple sclerosis. We examined Th17/Treg immune responses and the underlying mechanisms in response to metformin in C57BL/6 mice with experimental autoimmune encephalomyelitis (EAE). Metformin reduc...

journal_title：Journal of neuroimmunology

authors： Sun Y,Tian T,Gao J,Liu X,Hou H,Cao R,Li B,Quan M,Guo L

更新日期：2016-03-15 00:00:00