Abstract:
:A systematic study of thymus homogenates and cell suspensions from 13 patients with myasthenia gravis (MG) of recent onset, and 6 non-myasthenic controls, has failed to detect or isolate virus by cell culture with 'rescue techniques', electron microscopy, or intracerebral inoculation into neonatal mice. These results do not support the case for persistent viral infection in the thymus, and impose constraints on hypotheses of a viral aetiology of MG.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Klavinskis LS,Willcox HN,Richmond JE,Newsom-Davis Jdoi
10.1016/0165-5728(86)90082-2subject
Has Abstractpub_date
1986-06-01 00:00:00pages
287-99issue
4eissn
0165-5728issn
1872-8421pii
0165-5728(86)90082-2journal_volume
11pub_type
杂志文章abstract::A single intracerebroventricular injection of 100 ng of beta-endorphin altered the course of the central nervous system (CNS) infection of a temperature-sensitive mutant of vesicular stomatitis virus (VSV), tsG31-KS5. When mice were administered beta-endorphin and then 24 h later infected intracerebrally with tsG31-KS...
journal_title:Journal of neuroimmunology
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doi:10.1016/0165-5728(89)90097-0
更新日期:1989-09-01 00:00:00
abstract::Major histocompatibility complex (MHC) class II molecules are expressed on myoblasts after interferon-gamma (IFN-gamma) treatment, suggesting a muscle cell involvement in antigen presentation in inflammatory myopathies. However, they were not observed on normal or pathological myofibers. This discrepancy might be rela...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/0165-5728(96)00068-9
更新日期:1996-08-01 00:00:00
abstract::Mutations in the GBA gene are related to an increased risk of developing neurodegenerative diseases. The exact molecular mechanisms involved in the interaction between GBA and α-synuclein, a protein that has been associated with several neurological diseases, remain unsolved. Brain-derived neurotrophic factor (BDNF) i...
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更新日期:2015-01-15 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/s0165-5728(99)00034-x
更新日期:1999-05-03 00:00:00
abstract::Autotaxin (ATX) is an enzyme producing lysophosphatidic acid (LPA) from lysophosphatidyl choline (LPC) and it is up-regulated in inflammatory conditions such as various cancers, arthritis and multiple sclerosis (MS). Numerous studies have shown that the LPA signaling gives rise to angiogenesis, mitosis, cell prolifera...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2014.06.006
更新日期:2014-08-15 00:00:00
abstract::We report human leukocyte antigen (HLA) class I expression in 5-17% and class II in 0-9% of first trimester human spinal cord cells. After 8 days in culture with gamma-interferon, >87% of the spinal cord cells expressed HLA class II. However, mixed cultures of adult human peripheral lymphocytes and immature human spin...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/s0165-5728(00)00383-0
更新日期:2000-11-01 00:00:00
abstract::Experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats by inoculation with myelin basic protein (MBP) and adjuvants. Rats were treated with second daily injections of saline or cyclosporin A (CsA) from the day of inoculation. Saline-treated rats had an acute episode of disease followed by clinical r...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:1999-06-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/s0165-5728(97)00058-1
更新日期:1997-06-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2014.12.009
更新日期:2015-01-15 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章,评审
doi:10.1016/s0165-5728(99)00084-3
更新日期:1999-08-03 00:00:00
abstract::The mechanisms leading to CNS disorders after EBV infections are unclear. We report the case of a patient who developed a severe, but reversible, encephalopathy following an infectious mononucleosis. We detected no EBV DNA in the blood or in the cerebrospinal fluid (CSF) and no EBV-specific antibodies in the CSF. Howe...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2007.09.023
更新日期:2007-12-01 00:00:00
abstract::CCL19 and CCL21 bind to CCR7, which is crucial for both inducing an immune response and establishing immunological tolerance. We report that in the normal human brain CCL19, but not CCL21, is transcribed, and detectable as a protein in tissue lysates and in cerebrospinal fluid. In both active and inactive multiple scl...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2007.07.024
更新日期:2007-10-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2002-12-01 00:00:00
abstract::Humoral and cell-mediated immune responses of inbred BALB/c male mice were assayed for differential reactivities associated with behavioral sidedness, which was evaluated by spontaneous rotational behavior in a circular cage model system. Mice with left-turning preference had lower in vivo primary IgM and IgG anti-Key...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/0165-5728(89)90104-5
更新日期:1989-09-01 00:00:00
abstract::This study aimed to determine the seasonal impact on the clinical onset of inflammatory neurological diseases of the central nervous system by analyzing the onset month with information on clinical manifestations in Japanese patients. As a result, patients with anti-aquaporin-4 antibodies (AQP4-IgG)-positive neuromyel...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jneuroim.2020.577431
更新日期:2020-12-15 00:00:00
abstract::Single nucleotide polymorphisms in human pro- and anti-inflammatory genes, including IL1RN VNTR (rs315952), IL1A 4845G>T (rs17561), L1B-511C>T (rs16944), IL6-174G>C (rs1800795), IL10-1082 A>G (rs 1800896) and TNFα-308G>A (rs1800629) and their impact on multiple sclerosis risk and disease progression in a Polish popula...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
abstract::Some patients with peripheral neuropathy and gammopathy have IgM monoclonal antibodies that react with the myelin-associated glycoprotein (MAG), some 20-26 kDa glycoproteins present only in the peripheral nervous system (PNS), and some acidic glycolipids that are also PNS-specific. This communication describes an inve...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/0165-5728(86)90114-1
更新日期:1986-04-01 00:00:00
abstract::Immunofluorescence studies of sural nerve demonstrated immune reactive C3d and IgM on the surface of myelin sheaths in seven patients with neuropathy and an anti-myelin-associated glycoprotein (MAG) IgM M-protein. Similar deposits of C3d and sometimes IgM were found in four of six patients with acute or chronic inflam...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/0165-5728(88)90101-4
更新日期:1988-06-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2012-05-15 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2003-02-01 00:00:00
abstract::Primary angiitis of the central nervous system (PACNS) is a rare and heterogeneous inflammatory disease of the CNS vasculature with poorly understood pathophysiology. Comprehensive immune-cell phenotyping revealed increased frequencies of leukocytes in the cerebrospinal fluid (CSF) of PACNS patients compared to patien...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
doi:10.1016/j.jneuroim.2018.06.004
更新日期:2018-08-15 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章,评审
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更新日期:2008-07-31 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2020-12-15 00:00:00
abstract::TNF is a marker of disease activity in bacterial meningitis. To investigate TNF modulation by Toll-like receptor-2 (TLR2), we studied temporal and anatomical expression patterns of TLR2 and TNF in a pneumococcal meningitis model in wild type (wt) and TLR2(-/-) mice. We show by in situ hybridization that transcripts of...
journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:2005-11-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:1993-09-01 00:00:00
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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journal_title:Journal of neuroimmunology
pub_type: 杂志文章
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更新日期:1993-06-01 00:00:00
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