Abstract:
:This study analyzes how the antigen specificity, the subtype, and the activation state of T cells modulate their recently discovered neuroprotective potential. We assessed the prevention from neuronal damage in organotypic entorhinal-hippocampal slice cultures after co-culture with Th1 and Th2 cells either specific for myelin basic protein (MBP) or ovalbumin (OVA). We found that MBP-specific Th2 cells were the most effective in preventing central nervous system (CNS) tissue from secondary injury. This neuroprotective T cell effect appears to be mediated by soluble factors. After stimulation with phorbol myristate acetate and ionomycin, all T cells were most effective in preventing neuronal death. Our data show that the T cell subtype and activation state are important features in determining the neuroprotective potential of these cells.
journal_name
J Neuroimmunoljournal_title
Journal of neuroimmunologyauthors
Wolf SA,Fisher J,Bechmann I,Steiner B,Kwidzinski E,Nitsch Rdoi
10.1016/s0165-5728(02)00367-3subject
Has Abstractpub_date
2002-12-01 00:00:00pages
72-80issue
1-2eissn
0165-5728issn
1872-8421pii
S0165572802003673journal_volume
133pub_type
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pub_type: 杂志文章,评审
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