Intravenous immunoglobulin suppresses experimental myasthenia gravis: immunological mechanisms.

Abstract:

:Intravenous immunoglobulin (IVIG) administration has been beneficially used in the treatment of several autoimmune disorders including myasthenia gravis (MG), although its mechanism of action is still not clear. To study the optimal conditions of IVIG treatment and delineate its mechanism of action we established a suitable model in rat experimental autoimmune MG (EAMG). We show that IVIG has a suppressive effect on the clinical symptoms of ongoing EAMG that is associated with decreased AChR-specific cellular and humoral immune reactivity. Costimulatory factors and cytokine profile analyses suggest that IVIG immunomodulation in EAMG involves suppression of B and Th1-type T cell responses with no generation of T-regulatory cells. Our data contribute to the understanding of the immunological mechanisms underlying IVIG treatment in MG and in other autoimmune disorders.

journal_name

J Neuroimmunol

authors

Zhu KY,Feferman T,Maiti PK,Souroujon MC,Fuchs S

doi

10.1016/j.jneuroim.2006.04.011

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

187-97

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(06)00143-3

journal_volume

176

pub_type

杂志文章
  • Regional difference in inflammatory response to LPS-injection in the brain: role of microglia cell density.

    abstract::To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays using three different densities of N13 microglia stimulated with LPS. Our results showed that induction of pro-inflammatory factors as TNF-α and iNOS was directly related to cell density, meanwhi...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2011.06.017

    authors: Pintado C,Revilla E,Vizuete ML,Jiménez S,García-Cuervo L,Vitorica J,Ruano D,Castaño A

    更新日期:2011-09-15 00:00:00

  • Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cells.

    abstract::Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles. In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compa...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(02)00106-6

    authors: Calabresi PA,Yun SH,Allie R,Whartenby KA

    更新日期:2002-06-01 00:00:00

  • Dopaminergic receptors and adrenoceptors in circulating lymphocytes as putative biomarkers for the early onset and progression of multiple sclerosis.

    abstract::Clinically isolated syndrome (CIS) is a first, usually recovering, episode of neurological disturbance(s) suggestive of multiple sclerosis (MS). CIS subjects might benefit from early disease-modifying drugs, provided that those at high risk of developing MS can be identified. Gene expression for dopaminergic receptors...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2016.07.008

    authors: Cosentino M,Zaffaroni M,Legnaro M,Bombelli R,Schembri L,Baroncini D,Bianchi A,Clerici R,Guidotti M,Banfi P,Bono G,Marino F

    更新日期:2016-09-15 00:00:00

  • Immunocytochemical characterisation of cell cultures grown from dissociated 1-2-day post-natal rat cerebral tissue. A developmental study.

    abstract::A range of cell-specific markers have been employed with immunocytochemical methods to characterise and quantitate the cell types present in mixed brain cell cultures derived from dissociated 1-2-day post-natal rat cerebral hemispheres and grown in the presence of FCS. Protoplasmic astrocytes (GFAP+, A2B5-) were the m...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(84)80002-8

    authors: Walker AG,Chapman J,Bruce CB,Rumsby MG

    更新日期:1984-11-01 00:00:00

  • Methamphetamine and AIDS: 1HMRS studies in a feline model of human disease.

    abstract::Potential interactions between psychostimulant drugs and infection with feline immunodeficiency virus (FIV) on brain metabolism were evaluated. Four groups of cats were studied: control, FIV positive, methamphetamine (MA) exposed, and FIV positive plus MA exposed. Frontal gray matter, frontal white matter, and caudate...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2003.10.009

    authors: Cloak CC,Chang L,Ernst T,Barr MC,Huitron-Resendiz S,Sanchez-Alavez M,Phillips TR,Henriksen S

    更新日期:2004-02-01 00:00:00

  • Alternative splicing of interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7Ralpha) in peripheral blood from patients with multiple sclerosis (MS).

    abstract::IL-7 and IL-7Ralpha (IL-7R) form a non-redundant ligand receptor system which plays a crucial role in human T cell immunity. Both IL-7 and IL-7R are multi-exonal genes and exhibit alternative splicing. We measured the relative distribution of IL-7 and IL-7R spliced mRNA from patients with MS and healthy individuals an...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2010.02.014

    authors: Rane L,Vudattu N,Bourcier K,Graniar E,Hillert J,Seyfert V,Maeurer MJ

    更新日期:2010-05-01 00:00:00

  • Results of a phase I study in patients suffering from secondary-progressive multiple sclerosis demonstrating the safety of the amino acid copolymer PI-2301 and a possible induction of an anti-inflammatory cytokine response.

    abstract::PI-2301 is an immunomodulator that could be an alternative therapy for MS. A placebo-controlled, multiple-ascending dose, double-blind study was performed in patients with secondary-progressive MS. Treatment was given subcutaneously once weekly for 8 weeks, followed by a 4-week open-label treatment period with active ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jneuroim.2010.04.008

    authors: Kovalchin J,Krieger J,Genova M,Collins K,Augustyniak M,Masci A,Hittinger T,Kuca B,Edan G,Braudeau C,Rimbert M,Patel U,Mascioli E,Zanelli E

    更新日期:2010-08-25 00:00:00

  • EPA protects against muscle damage in the mdx mouse model of Duchenne muscular dystrophy by promoting a shift from the M1 to M2 macrophage phenotype.

    abstract::In dystrophic mdx mice and in Duchenne muscular dystrophy, inflammation contributes to myonecrosis. Previously, we demonstrated that eicosapentaenoic acid (EPA) decreased inflammation and necrosis in dystrophic muscle. In the present study, we examined the effects of EPA and the corticoid deflazacort (DFZ) as modulato...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2013.09.007

    authors: Carvalho SC,Apolinário LM,Matheus SM,Santo Neto H,Marques MJ

    更新日期:2013-11-15 00:00:00

  • Immunostimulant patches containing Escherichia coli LT enhance immune responses to DNA- and recombinant protein-based Alzheimer's disease vaccines.

    abstract::Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Escherichia coli heat-labile enterotoxin adjuvant-laden immunostimulato...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2014.01.002

    authors: Davtyan H,Ghochikyan A,Hovakimyan A,Petrushina I,Yu J,Flyer D,Madsen PJ,Pedersen LO,Cribbs DH,Agadjanyan MG

    更新日期:2014-03-15 00:00:00

  • Stiff person spectrum disorders: An illustrative case series of their phenotypic and antibody diversity.

    abstract::Stiff person spectrum disorders (SPSD) are a broad group of immune-mediated disorders. Clinical presentations include classical stiff person syndrome (SPS), focal SPS, and progressive encephalomyelitis with rigidity and myoclonus (PERM). The most frequently associated antibodies are anti-GAD65, anti-GlyR, anti-amphiph...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jneuroim.2020.577192

    authors: Bernardo F,Rebordão L,Rêgo A,Machado S,Passos J,Costa C,Cruz S,Pinto AN,Santos M

    更新日期:2020-04-15 00:00:00

  • Fluorescence-activated cell sorter analysis of bulk-isolated porcine oligodendrocytes.

    abstract::We describe here the methods by which enriched populations of oligodendrocytes were isolated from adult porcine brains using Percoll density gradient centrifugation and their immunological properties analyzed by a fluorescence-activated cell sorter (FACS). The analyses by immunofluorescence microscopy and FACS indicat...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(86)90049-4

    authors: Smyrnis E,Kim SU,Kim MW,Oger J,Sylvester C,Paty DW

    更新日期:1986-11-01 00:00:00

  • Band 1 and voltage-sensitive Na+ channels are not codistributed in cultured rodent neuronal cells.

    abstract::The relationship of the mouse nervous system specific band 1 protein to the putative high molecular weight component of the Na+ channel was investigated using antibody to band 1. Morphologic differentiation of cultured neuroblastoma cells has been reported to increase the quantity of the putative Na+ channel high mole...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(81)90028-x

    authors: Akeson R,Graham K

    更新日期:1981-09-01 00:00:00

  • Therapeutic effects of anti-Delta1 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease.

    abstract::We examined the role of Notch ligand Delta-like 1 (Delta1) in the development of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD). Blocking of Delta1 by anti-Delta1 monoclonal antibody (mAb) in the effector phase significantly suppressed the disease development of TMEV-IDD both ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2012.08.003

    authors: Tsugane S,Takizawa S,Kaneyama T,Ichikawa M,Yagita H,Kim BS,Koh CS

    更新日期:2012-11-15 00:00:00

  • 2D immunomic approach for the study of IgG autoantibodies in the experimental model of multiple sclerosis.

    abstract::2D-immunomics may be useful in the identification of autoantigens in neurological autoimmune diseases, but its application may be limited by denaturation of target proteins. Here we compared the capacity of a single or multiple antigens to elicit autoantibodies targeting multiple neural autoantigens by ELISA and 2D-im...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2010.10.004

    authors: Farinazzo A,Gini B,Milli A,Ruffini F,Marconi S,Turano E,Anghileri E,Barbieri F,Cecconi D,Furlan R,Bonetti B

    更新日期:2011-03-01 00:00:00

  • Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay.

    abstract::NMO-IgG, a disease-specific autoantibody for neuromyelitis optica, recognizes aquaporin-4 (AQP4) and has been examined by indirect immunofluorescence assay. We developed an enzyme-linked immunosorbent assay (ELISA) to detect anti-AQP4 antibodies by establishing methods for expression in a baculovirus system and purifi...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2008.03.009

    authors: Hayakawa S,Mori M,Okuta A,Kamegawa A,Fujiyoshi Y,Yoshiyama Y,Mitsuoka K,Ishibashi K,Sasaki S,Hattori T,Kuwabara S

    更新日期:2008-05-30 00:00:00

  • Clinical and MRI correlates of autoreactive antibodies in multiple sclerosis patients.

    abstract:BACKGROUND:Autoreactive antibodies (ARAB) occur more frequently in patients with multiple sclerosis (MS) than in general population and the presence of these antibodies often causes uncertainty regarding the disease course, response to therapy and the diagnosis of MS. METHODS:Retrospective analyses of the ARAB, clinic...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2007.04.008

    authors: Garg N,Zivadinov R,Ramanathan M,Vasiliu I,Locke J,Watts K,Lema J,Rajeswary J,Munschauer FE,Ambrus J Jr,Weinstock-Guttman B

    更新日期:2007-07-01 00:00:00

  • Oligodendrocyte precursor cells express a functional chemokine receptor CCR3: implications for myelination.

    abstract::Myelination in the central nervous system requires an accurate interplay between oligodendrocyte precursor cells (OPC) and axons. By as yet not fully understood mechanisms, OPC proliferate, migrate to the axon to be myelinated and finally differentiate into mature oligodendrocytes. The recent finding that OPC express ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2006.05.021

    authors: Maysami S,Nguyen D,Zobel F,Heine S,Höpfner M,Stangel M

    更新日期:2006-09-01 00:00:00

  • Reduction of the microglial cell number in rat primary glial cell cultures by exogenous addition of dibutyryl cyclic adenosine monophosphate.

    abstract::The present work examined the effects induced by dibutyryl cyclic adenosine monophosphate (dB-cAMP) on microglial cells in primary glial cell cultures from newborn rats. Microglial cells were identified by OX42 immunohistochemistry and nucleoside diphosphatase histochemistry. Double staining for astrocytes was carried...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(96)00074-4

    authors: Dalmau I,Castellano B,Pedersen EB,Finsen B,Zimmer J,González B

    更新日期:1996-11-01 00:00:00

  • A subset of Schwann cells in peripheral nerves contain a 50-kDa protein antigenically related to astrocyte intermediate filaments.

    abstract::Antisera raised to the astrocyte intermediate filament structural protein stained elements in the peripheral nerves of several species. These elements were not associated with myelinated nerve fibers, were more common in splenic and vagus nerves than in the sciatic nerve, and persisted after nerve transection. In teas...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(85)80070-9

    authors: Fields KL,Yen SH

    更新日期:1985-06-01 00:00:00

  • Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain.

    abstract::A recent meta-analysis of genome-wide association screens coupled to a replication exercise in a combined US/UK collection led to the identification of 4 single nucleotide polymorphisms (SNPs) in three gene loci, i.e. TNFRSF1A, CD6 and IRF8, as novel risk factors for multiple sclerosis with genome-wide level of signif...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2010.03.020

    authors: Swaminathan B,Matesanz F,Cavanillas ML,Alloza I,Otaegui D,Olascoaga J,Cénit MC,de las Heras V,Barcina MG,Arroyo R,Alcina A,Fernandez O,Antigüedad A,Urcelay E,Vandenbroeck K

    更新日期:2010-06-01 00:00:00

  • TLR-2 neutralization potentiates microglial M1 to M2 switching by the combinatorial treatment of ciprofloxacin and dexamethasone during S. aureus infection.

    abstract::Microglial inflammation plays a pivotal role in the pathogenesis of S. aureus induced brain abscesses. The objective of this study was to regulate microglial activation by the combinatorial treatment of ciprofloxacin either with dexamethasone or celecoxib via targeting M1 and M2 polarization. The antibiotic-immunomodu...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2020.577262

    authors: Dey R,Bishayi B

    更新日期:2020-07-15 00:00:00

  • Antibody-secreting cells in the central nervous system in an animal model of MS: Phenotype, association with disability, and in vitro production of antibody.

    abstract::Little is known about antibody production within the central nervous system, called intrathecal antibody production (ITAbP). Mice infected with Theiler's murine encephalomyocarditis virus (TMEV) develop an immune-mediated demyelinating disease(TMEV-IDD), characterized by progressive weakness associated with robust ITA...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2007.09.001

    authors: Pachner AR,Brady J,Narayan K

    更新日期:2007-10-01 00:00:00

  • Longitudinal epitope mapping in MuSK myasthenia gravis: implications for disease severity.

    abstract::Muscle weakness in MuSK myasthenia gravis (MG) is caused predominantly by IgG4 antibodies which block MuSK signalling and destabilize neuromuscular junctions. We determined whether the binding pattern of MuSK IgG4 antibodies change throughout the disease course ("epitope spreading"), and affect disease severity or tre...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2015.12.016

    authors: Huijbers MG,Vink AF,Niks EH,Westhuis RH,van Zwet EW,de Meel RH,Rojas-García R,Díaz-Manera J,Kuks JB,Klooster R,Straasheijm K,Evoli A,Illa I,van der Maarel SM,Verschuuren JJ

    更新日期:2016-02-15 00:00:00

  • T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes.

    abstract::Several studies have proposed cerebral malaria (CM) as a CD4+ and CD8+ T lymphocyte-mediated disease. However, there are no data regarding the recruitment and/or persistence of these cells in the CNS following the phase of infection resolution. Glutamate-mediate excitotoxicity has also been implicated in CM. Blockade ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2019.02.002

    authors: de Miranda AS,Ferreira RN,Vieira ÉLM,Abreu LKS,Brant F,Vieira LB,Ribeiro FM,Machado FS,Rachid MA,Teixeira AL

    更新日期:2019-05-15 00:00:00

  • Increase of CD8+ T-effector memory cells in peripheral blood of patients with relapsing-remitting multiple sclerosis compared to healthy controls.

    abstract::CCR7 and CD45RA expression on CD4+ and CD8+ T-cells in blood (PB) of 16 patients with multiple sclerosis (MS) and 16 healthy controls and cerebrospinal fluid (CSF) of 10 patients suffering from MS were analysed by flow cytometric measurements. T-cells were divided by their distinct homing potentials and effector-funct...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2006.09.008

    authors: Haegele KF,Stueckle CA,Malin JP,Sindern E

    更新日期:2007-02-01 00:00:00

  • Serial blood T cell repertoire alterations in multiple sclerosis patients; correlation with clinical and MRI parameters.

    abstract::A significant skewing of the peripheral T cell repertoire has been shown in relapsing-remitting multiple sclerosis (MS). Most of the studies already performed in this field are cross-sectional and therefore, little is known of the T cell repertoire evolution over time in MS and the correlation of T cell repertoire var...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2006.05.006

    authors: Laplaud DA,Berthelot L,Miqueu P,Bourcier K,Moynard J,Oudinet Y,Guillet M,Ruiz C,Oden N,Brouard S,Guttmann CR,Weiner HL,Khoury SJ,Soulillou JP

    更新日期:2006-08-01 00:00:00

  • Activation thresholds determine susceptibility to peptide-induced tolerance in a heterogeneous myelin-reactive T cell repertoire.

    abstract::Altered peptide ligands (APL) with increased MHC-binding properties are highly effective at inducing T cell tolerance after systemic administration in soluble form, preventing experimental autoimmune encephalomyelitis (EAE) induced with the myelin basic protein (MBP) Ac1-9 peptide. We have previously described a diver...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/j.jneuroim.2004.07.010

    authors: McCue D,Ryan KR,Wraith DC,Anderton SM

    更新日期:2004-11-01 00:00:00

  • Protective effect of the interleukin-1 receptor antagonist (IL-1ra) on experimental allergic encephalomyelitis in rats.

    abstract::Cytokines such as interleukin-1 (IL-1) are thought to contribute to the inflammatory response associated with autoimmune diseases like multiple sclerosis. We assessed the role of IL-1 in an animal model of MS, experimental allergic encephalomyelitis (EAE), by testing the effects of treatment with an IL-1 receptor anta...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/0165-5728(95)00108-e

    authors: Martin D,Near SL

    更新日期:1995-09-01 00:00:00

  • Serum CD95 of relapsing remitting multiple sclerosis patients protects from CD95-mediated apoptosis.

    abstract::Failure of CD95-mediated apoptosis as a potential negative regulatory mechanism of T cell expansion may be involved in T cell-mediated autoimmune diseases such as multiple sclerosis (MS). Recently, soluble CD95 has been shown to be elevated in MS patients with active disease. Here, we report that the sera of MS patien...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章

    doi:10.1016/s0165-5728(98)00032-0

    authors: Zipp F,Otzelberger K,Dichgans J,Martin R,Weller M

    更新日期:1998-06-15 00:00:00

  • Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis.

    abstract::We examined immune function and changes in T cell populations over a 1-year period in a series of progressive multiple sclerosis (MS) patients treated with different regimens of cyclophosphamide/ACTH as part of the Northeast Multiple Sclerosis Treatment Group. Our studies were designed to determine the effect of diffe...

    journal_title:Journal of neuroimmunology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0165-5728(91)90007-t

    authors: Hafler DA,Orav J,Gertz R,Stazzone L,Weiner HL

    更新日期:1991-05-01 00:00:00