Intravenous immunoglobulin suppresses experimental myasthenia gravis: immunological mechanisms.


:Intravenous immunoglobulin (IVIG) administration has been beneficially used in the treatment of several autoimmune disorders including myasthenia gravis (MG), although its mechanism of action is still not clear. To study the optimal conditions of IVIG treatment and delineate its mechanism of action we established a suitable model in rat experimental autoimmune MG (EAMG). We show that IVIG has a suppressive effect on the clinical symptoms of ongoing EAMG that is associated with decreased AChR-specific cellular and humoral immune reactivity. Costimulatory factors and cytokine profile analyses suggest that IVIG immunomodulation in EAMG involves suppression of B and Th1-type T cell responses with no generation of T-regulatory cells. Our data contribute to the understanding of the immunological mechanisms underlying IVIG treatment in MG and in other autoimmune disorders.


J Neuroimmunol


Zhu KY,Feferman T,Maiti PK,Souroujon MC,Fuchs S




Has Abstract


2006-07-01 00:00:00














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    abstract::To elucidate whether density of cells could contribute to the extent of microglial activation, we performed in vitro assays using three different densities of N13 microglia stimulated with LPS. Our results showed that induction of pro-inflammatory factors as TNF-α and iNOS was directly related to cell density, meanwhi...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Pintado C,Revilla E,Vizuete ML,Jiménez S,García-Cuervo L,Vitorica J,Ruano D,Castaño A

    更新日期:2011-09-15 00:00:00

  • Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cells.

    abstract::Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles. In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compa...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Calabresi PA,Yun SH,Allie R,Whartenby KA

    更新日期:2002-06-01 00:00:00

  • Dopaminergic receptors and adrenoceptors in circulating lymphocytes as putative biomarkers for the early onset and progression of multiple sclerosis.

    abstract::Clinically isolated syndrome (CIS) is a first, usually recovering, episode of neurological disturbance(s) suggestive of multiple sclerosis (MS). CIS subjects might benefit from early disease-modifying drugs, provided that those at high risk of developing MS can be identified. Gene expression for dopaminergic receptors...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Cosentino M,Zaffaroni M,Legnaro M,Bombelli R,Schembri L,Baroncini D,Bianchi A,Clerici R,Guidotti M,Banfi P,Bono G,Marino F

    更新日期:2016-09-15 00:00:00

  • Immunocytochemical characterisation of cell cultures grown from dissociated 1-2-day post-natal rat cerebral tissue. A developmental study.

    abstract::A range of cell-specific markers have been employed with immunocytochemical methods to characterise and quantitate the cell types present in mixed brain cell cultures derived from dissociated 1-2-day post-natal rat cerebral hemispheres and grown in the presence of FCS. Protoplasmic astrocytes (GFAP+, A2B5-) were the m...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Walker AG,Chapman J,Bruce CB,Rumsby MG

    更新日期:1984-11-01 00:00:00

  • Methamphetamine and AIDS: 1HMRS studies in a feline model of human disease.

    abstract::Potential interactions between psychostimulant drugs and infection with feline immunodeficiency virus (FIV) on brain metabolism were evaluated. Four groups of cats were studied: control, FIV positive, methamphetamine (MA) exposed, and FIV positive plus MA exposed. Frontal gray matter, frontal white matter, and caudate...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Cloak CC,Chang L,Ernst T,Barr MC,Huitron-Resendiz S,Sanchez-Alavez M,Phillips TR,Henriksen S

    更新日期:2004-02-01 00:00:00

  • Alternative splicing of interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7Ralpha) in peripheral blood from patients with multiple sclerosis (MS).

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Rane L,Vudattu N,Bourcier K,Graniar E,Hillert J,Seyfert V,Maeurer MJ

    更新日期:2010-05-01 00:00:00

  • Results of a phase I study in patients suffering from secondary-progressive multiple sclerosis demonstrating the safety of the amino acid copolymer PI-2301 and a possible induction of an anti-inflammatory cytokine response.

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,随机对照试验


    authors: Kovalchin J,Krieger J,Genova M,Collins K,Augustyniak M,Masci A,Hittinger T,Kuca B,Edan G,Braudeau C,Rimbert M,Patel U,Mascioli E,Zanelli E

    更新日期:2010-08-25 00:00:00

  • EPA protects against muscle damage in the mdx mouse model of Duchenne muscular dystrophy by promoting a shift from the M1 to M2 macrophage phenotype.

    abstract::In dystrophic mdx mice and in Duchenne muscular dystrophy, inflammation contributes to myonecrosis. Previously, we demonstrated that eicosapentaenoic acid (EPA) decreased inflammation and necrosis in dystrophic muscle. In the present study, we examined the effects of EPA and the corticoid deflazacort (DFZ) as modulato...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Carvalho SC,Apolinário LM,Matheus SM,Santo Neto H,Marques MJ

    更新日期:2013-11-15 00:00:00

  • Immunostimulant patches containing Escherichia coli LT enhance immune responses to DNA- and recombinant protein-based Alzheimer's disease vaccines.

    abstract::Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Escherichia coli heat-labile enterotoxin adjuvant-laden immunostimulato...

    journal_title:Journal of neuroimmunology

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    authors: Davtyan H,Ghochikyan A,Hovakimyan A,Petrushina I,Yu J,Flyer D,Madsen PJ,Pedersen LO,Cribbs DH,Agadjanyan MG

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  • Stiff person spectrum disorders: An illustrative case series of their phenotypic and antibody diversity.

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    pub_type: 杂志文章,评审


    authors: Bernardo F,Rebordão L,Rêgo A,Machado S,Passos J,Costa C,Cruz S,Pinto AN,Santos M

    更新日期:2020-04-15 00:00:00

  • Fluorescence-activated cell sorter analysis of bulk-isolated porcine oligodendrocytes.

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Smyrnis E,Kim SU,Kim MW,Oger J,Sylvester C,Paty DW

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  • Band 1 and voltage-sensitive Na+ channels are not codistributed in cultured rodent neuronal cells.

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Akeson R,Graham K

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    authors: Tsugane S,Takizawa S,Kaneyama T,Ichikawa M,Yagita H,Kim BS,Koh CS

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    journal_title:Journal of neuroimmunology

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    authors: Farinazzo A,Gini B,Milli A,Ruffini F,Marconi S,Turano E,Anghileri E,Barbieri F,Cecconi D,Furlan R,Bonetti B

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    更新日期:2008-05-30 00:00:00

  • Clinical and MRI correlates of autoreactive antibodies in multiple sclerosis patients.

    abstract:BACKGROUND:Autoreactive antibodies (ARAB) occur more frequently in patients with multiple sclerosis (MS) than in general population and the presence of these antibodies often causes uncertainty regarding the disease course, response to therapy and the diagnosis of MS. METHODS:Retrospective analyses of the ARAB, clinic...

    journal_title:Journal of neuroimmunology

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    authors: Garg N,Zivadinov R,Ramanathan M,Vasiliu I,Locke J,Watts K,Lema J,Rajeswary J,Munschauer FE,Ambrus J Jr,Weinstock-Guttman B

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  • Oligodendrocyte precursor cells express a functional chemokine receptor CCR3: implications for myelination.

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    journal_title:Journal of neuroimmunology

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    authors: Maysami S,Nguyen D,Zobel F,Heine S,Höpfner M,Stangel M

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    authors: Dalmau I,Castellano B,Pedersen EB,Finsen B,Zimmer J,González B

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  • A subset of Schwann cells in peripheral nerves contain a 50-kDa protein antigenically related to astrocyte intermediate filaments.

    abstract::Antisera raised to the astrocyte intermediate filament structural protein stained elements in the peripheral nerves of several species. These elements were not associated with myelinated nerve fibers, were more common in splenic and vagus nerves than in the sciatic nerve, and persisted after nerve transection. In teas...

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    abstract::A recent meta-analysis of genome-wide association screens coupled to a replication exercise in a combined US/UK collection led to the identification of 4 single nucleotide polymorphisms (SNPs) in three gene loci, i.e. TNFRSF1A, CD6 and IRF8, as novel risk factors for multiple sclerosis with genome-wide level of signif...

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    authors: Swaminathan B,Matesanz F,Cavanillas ML,Alloza I,Otaegui D,Olascoaga J,Cénit MC,de las Heras V,Barcina MG,Arroyo R,Alcina A,Fernandez O,Antigüedad A,Urcelay E,Vandenbroeck K

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  • TLR-2 neutralization potentiates microglial M1 to M2 switching by the combinatorial treatment of ciprofloxacin and dexamethasone during S. aureus infection.

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


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  • Antibody-secreting cells in the central nervous system in an animal model of MS: Phenotype, association with disability, and in vitro production of antibody.

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    authors: Pachner AR,Brady J,Narayan K

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  • Longitudinal epitope mapping in MuSK myasthenia gravis: implications for disease severity.

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Huijbers MG,Vink AF,Niks EH,Westhuis RH,van Zwet EW,de Meel RH,Rojas-García R,Díaz-Manera J,Kuks JB,Klooster R,Straasheijm K,Evoli A,Illa I,van der Maarel SM,Verschuuren JJ

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Haegele KF,Stueckle CA,Malin JP,Sindern E

    更新日期:2007-02-01 00:00:00

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Laplaud DA,Berthelot L,Miqueu P,Bourcier K,Moynard J,Oudinet Y,Guillet M,Ruiz C,Oden N,Brouard S,Guttmann CR,Weiner HL,Khoury SJ,Soulillou JP

    更新日期:2006-08-01 00:00:00

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: McCue D,Ryan KR,Wraith DC,Anderton SM

    更新日期:2004-11-01 00:00:00

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Martin D,Near SL

    更新日期:1995-09-01 00:00:00

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    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Zipp F,Otzelberger K,Dichgans J,Martin R,Weller M

    更新日期:1998-06-15 00:00:00

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    journal_title:Journal of neuroimmunology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hafler DA,Orav J,Gertz R,Stazzone L,Weiner HL

    更新日期:1991-05-01 00:00:00