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Intravenous immunoglobulin suppresses experimental myasthenia gravis: immunological mechanisms.

Abstract：

:Intravenous immunoglobulin (IVIG) administration has been beneficially used in the treatment of several autoimmune disorders including myasthenia gravis (MG), although its mechanism of action is still not clear. To study the optimal conditions of IVIG treatment and delineate its mechanism of action we established a suitable model in rat experimental autoimmune MG (EAMG). We show that IVIG has a suppressive effect on the clinical symptoms of ongoing EAMG that is associated with decreased AChR-specific cellular and humoral immune reactivity. Costimulatory factors and cytokine profile analyses suggest that IVIG immunomodulation in EAMG involves suppression of B and Th1-type T cell responses with no generation of T-regulatory cells. Our data contribute to the understanding of the immunological mechanisms underlying IVIG treatment in MG and in other autoimmune disorders.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Zhu KY,Feferman T,Maiti PK,Souroujon MC,Fuchs S

doi

10.1016/j.jneuroim.2006.04.011

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

187-97

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(06)00143-3

journal_volume

176

pub_type

杂志文章

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