Intravenous immunoglobulin suppresses experimental myasthenia gravis: immunological mechanisms.


:Intravenous immunoglobulin (IVIG) administration has been beneficially used in the treatment of several autoimmune disorders including myasthenia gravis (MG), although its mechanism of action is still not clear. To study the optimal conditions of IVIG treatment and delineate its mechanism of action we established a suitable model in rat experimental autoimmune MG (EAMG). We show that IVIG has a suppressive effect on the clinical symptoms of ongoing EAMG that is associated with decreased AChR-specific cellular and humoral immune reactivity. Costimulatory factors and cytokine profile analyses suggest that IVIG immunomodulation in EAMG involves suppression of B and Th1-type T cell responses with no generation of T-regulatory cells. Our data contribute to the understanding of the immunological mechanisms underlying IVIG treatment in MG and in other autoimmune disorders.


J Neuroimmunol


Zhu KY,Feferman T,Maiti PK,Souroujon MC,Fuchs S




Has Abstract


2006-07-01 00:00:00














  • Antibodies to interleukin-1 inhibit cytokine-induced proliferation of neonatal rat Schwann cells in vitro.

    abstract::Unfractionated cytokines have been shown to induce in vitro proliferation of neonatal rat Schwann cells but the nature of the mitogen(s) is not known. A mixture of rabbit antibodies specific for recombinant interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) inhibited Schwann cell proliferation induced...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Lisak RP,Bealmear B

    更新日期:1991-02-01 00:00:00

  • Family-based association study of interleukin 6 (IL6) and its receptor (IL6R) functional polymorphisms in schizophrenia in the Polish population.

    abstract::Schizophrenia is a heterogeneous disorder and its etiology remains incompletely elucidated. Among possible causes, immunological factors have been implicated in its pathogenesis and course. The inflammatory system may trigger or modulate the course of schizophrenia through complex mechanisms influencing neurodevelopme...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Kapelski P,Skibinska M,Maciukiewicz M,Pawlak J,Permoda-Osip A,Twarowska-Hauser J

    更新日期:2015-08-15 00:00:00

  • TDP-43 proteolysis is associated with astrocyte reactivity after traumatic brain injury in rodents.

    abstract::The aggregation and deposition of transactivation response DNA-binding protein 43 (TDP-43) in neurons and astrocytes is characteristic in a number of neurodegenerative diseases including Alzheimer's disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis. Nevertheless, the exact role of TDP-43 in...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Huang CY,Lee YC,Li PC,Liliang PC,Lu K,Wang KW,Chang LC,Shiu LY,Chen MF,Sun YT,Wang HK

    更新日期:2017-12-15 00:00:00

  • Experimental autoimmune encephalomyelitis: isolation and characterization of inflammatory cells from the central nervous system.

    abstract::Lymphocytes from the central nervous system (CNS) of animals with acute experimental autoimmune encephalomyelitis (EAE) have been isolated and characterized. The lymphocytes were separated from Lewis rats which were injected either with an emulsion of myelin basic protein (BP) emulsified in complete Freund's adjuvant ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Lyman WD,Abrams GA,Raine CS

    更新日期:1989-12-01 00:00:00

  • Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation.

    abstract::Reactive oxygen intermediates (ROIs) are important mediators of a variety of pathological processes, including inflammation and ischemia/reperfusion injury. Cytokines and chemokines are detected at mRNA level in human and animal ischemic brains. This suggests that hypoxia/reoxygenation may induce cytokine production t...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Wang MJ,Huang HM,Hsieh SJ,Jeng KC,Kuo JS

    更新日期:2001-01-01 00:00:00

  • Increased expression of B cell-associated regulatory cytokines by glatiramer acetate in mice with experimental autoimmune encephalomyelitis.

    abstract::B cells are of increasing importance as a target for multiple sclerosis treatment. Here we show that GA treatment of mice with experimental autoimmune encephalomyelitis (EAE) biases cytokine production by B cells towards cytokines associated with regulation in MS including interleukin (IL)-4, -10 and -13 and reduces p...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Begum-Haque S,Sharma A,Christy M,Lentini T,Ochoa-Reparaz J,Fayed IF,Mielcarz D,Haque A,Kasper LH

    更新日期:2010-02-26 00:00:00

  • The importance of clinical trials in unraveling the mysteries of multiple sclerosis.

    abstract::Despite a number of new therapies that are effective in reducing the inflammatory component of multiple sclerosis, the underlying cause of the disease remains uncertain. One of the most powerful tools available to an investigator to help in unraveling the underlying disease mechanisms in MS is the incorporation of car...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: McFarland H

    更新日期:2011-02-01 00:00:00

  • A chemiluminescence assay to detect antibodies to brain surface antigens in human sera.

    abstract::A chemiluminescence assay was developed based on the interaction between antibodies binding to the surface of living brain cells in culture and macrophages. Such interaction leads to production of reactive oxygen radicals which can be measured by a chemiluminescence assay. This assay was used to detect anti brain anti...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Brügger M,Dayrell-Hart E,Meier C,Vandevelde M,Zurbriggen A

    更新日期:1994-01-01 00:00:00

  • A potential link between autoimmunity and neurodegeneration in immune-mediated neurological disease.

    abstract::Multiple sclerosis (MS) patients make antibodies to heterogeneous nuclear ribonuclear protein A1 (hnRNP-A1), a nucleocytoplasmic protein. We hypothesized this autoimmune reaction might contribute to neurodegeneration. Antibodies from MS patients reacted with hnRNP-A1-'M9', its nuclear translocation sequence. Transfect...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Lee S,Xu L,Shin Y,Gardner L,Hartzes A,Dohan FC,Raine C,Homayouni R,Levin MC

    更新日期:2011-06-01 00:00:00

  • T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes.

    abstract::Several studies have proposed cerebral malaria (CM) as a CD4+ and CD8+ T lymphocyte-mediated disease. However, there are no data regarding the recruitment and/or persistence of these cells in the CNS following the phase of infection resolution. Glutamate-mediate excitotoxicity has also been implicated in CM. Blockade ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: de Miranda AS,Ferreira RN,Vieira ÉLM,Abreu LKS,Brant F,Vieira LB,Ribeiro FM,Machado FS,Rachid MA,Teixeira AL

    更新日期:2019-05-15 00:00:00

  • Expression profile of long noncoding RNAs and mRNAs in peripheral blood mononuclear cells from myasthenia gravis patients.

    abstract::For the epigenetic characterization of myasthenia gravis (MG), we determined whether long noncoding RNAs (lncRNAs) and messenger RNAs (mRNAs) are expressed differentially in subjects with and without MG. Compared with healthy control subjects, the MG patients had 1561 upregulated lncRNAs, 1034 downregulated lncRNAs, 9...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Zhang F,Liu G,Bu Y,Ma X,Hao J

    更新日期:2016-10-15 00:00:00

  • Norepinephrine inhibits gamma-interferon-induced MHC class II (Ia) antigen expression on cultured brain astrocytes.

    abstract::Recent evidence that astrocytes can be induced to express the class II major histocompatability (MHC) antigens suggests that these cells may be involved in the development of intracerebral immune responses. The principal inducer of MHC class II antigen (Ia) expression is a soluble lymphokine, gamma-interferon (gamma-I...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Frohman EM,Vayuvegula B,van den Noort S,Gupta S

    更新日期:1988-01-01 00:00:00

  • The role of regulatory T cells in Lewis rats resistant to EAE.

    abstract::Adult Lewis (LEW) rats are highly susceptible to experimental autoimmune encephalomyelitis (EAE), induced actively by immunization with guinea pig (GP) myelin basic protein (MBP) in complete Freund's adjuvant or adoptively transferred with activated T lymphocytes reactive to GP MBP peptide 68-88. Once LEW rats recover...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Sun D,Wilson DB,Cao L,Whitaker JN

    更新日期:1998-01-01 00:00:00

  • Human neutrophil and macrophage chemokinesis induced by cardiopulmonary bypass: loss of DAME and IL-1 chemotaxis.

    abstract::Cardiopulmonary bypass (CPB) induces both cellular immunosuppression and an inflammatory response. In an effort to better characterize CPB-induced immune dysfunction, we examined the chemotaxic ability of human granulocytes and macrophages to D-Ala2-Met-enkephalin (DAME) and interleukin (IL)-1 alpha with computer-assi...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Stefano GB,Bilfinger TV

    更新日期:1993-09-01 00:00:00

  • Specificity of human IgM monoclonal antibodies from patients with peripheral neuropathy.

    abstract::Some patients with peripheral neuropathy and gammopathy have IgM monoclonal antibodies that react with the myelin-associated glycoprotein (MAG), some 20-26 kDa glycoproteins present only in the peripheral nervous system (PNS), and some acidic glycolipids that are also PNS-specific. This communication describes an inve...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: O'Shannessy DJ,Ilyas AA,Dalakas MC,Mendell JR,Quarles RH

    更新日期:1986-04-01 00:00:00

  • Interleukin-6, beta-amyloid peptide and NMDA interactions in rat cortical neurons.

    abstract::Neuronal damage in Alzheimer's disease (AD) is thought to involve direct toxicity of beta-amyloid peptide (Abeta) and excitotoxicity involving NMDA receptors (NMDARs) and altered Ca(2+) dynamics. Inflammation agents produced by microglia or astrocytes and associated with senile plaques such as the cytokine interleukin...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Qiu Z,Gruol DL

    更新日期:2003-06-01 00:00:00

  • Experimental autoimmune encephalomyelitis induced in B6.C-H-2bm12 mice by myelin oligodendrocyte glycoprotein: effect of MHC class II mutation on immunodominant epitope selection and fine epitope specificity of encephalitogenic T cells.

    abstract::The effect of the bm12 mutation on susceptibility to MOG-induced EAE, TCR repertoire and fine epitope specificity of the encephalitogenic T-cells, was assessed. prMOG35-55 was encephalitogenic for H-2bm12 and H-2b mice. Despite only minor differences in TCRVbeta expression and fine epitope specificity, H-2bm12/ and H-...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Mendel I,Gur H,Kerlero de Rosbo N,Ben-Nun A

    更新日期:1999-04-01 00:00:00

  • Characterization of naïve, memory and effector T cells in progressive multiple sclerosis.

    abstract::We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all su...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Nielsen BR,Ratzer R,Börnsen L,von Essen MR,Christensen JR,Sellebjerg F

    更新日期:2017-09-15 00:00:00

  • Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-κB pathway.

    abstract::The microglia-mediated neuroinflammation plays an important role in the pathogenesis of Alzheimer's disease (AD). Advanced glycation end products (AGEs)/receptor for advanced glycation end products (RAGE) or Rho/Rho kinase (ROCK) are both involved in the development of non-specific inflammation. However, there are few...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Chen J,Sun Z,Jin M,Tu Y,Wang S,Yang X,Chen Q,Zhang X,Han Y,Pi R

    更新日期:2017-04-15 00:00:00

  • Site-specific control of T cell traffic in the brain: T cell entry to brainstem vs. hippocampus after local injection of IFN-gamma.

    abstract::Although it is known that neurotransmitters and neuropeptides can affect immune function in vitro, less is understood about how the neural environment affects immune function in the brain. Previously, we showed that regulation of parenchymal class II MHC after local injection of IFN-gamma is site-specific. In this com...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Phillips LM,Lampson LA

    更新日期:1999-05-03 00:00:00

  • Altered peptide ligand modulation of experimental allergic encephalomyelitis: immune responses within the CNS.

    abstract::An altered peptide ligand (analog) of the encephalitogenic epitope of proteolipid protein residues 139-151 (p139-151) in which residues 144 and 147 are substituted with leucine and arginine, respectively (LR), protects from clinical but not histological experimental allergic encephalomyelitis (EAE). To understand in s...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Santambrogio L,Lees MB,Sobel RA

    更新日期:1998-01-01 00:00:00

  • Expression of mRNA for multiple serotonin (5-HT) receptor types/subtypes by the peripheral blood mononuclear cells of rhesus macaques.

    abstract::To find out whether rhesus macaque peripheral blood mononuclear cells (PBMCs) express mRNA for 5-HT receptors, blood samples from normal healthy rhesus monkeys were used to isolate PBMCs by Ficoll-paque density gradient centrifugation. Total RNA was extracted from MT-2 cells, Hut-78 cells, naive or phytohemagglutinin ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Yang GB,Qiu CL,Zhao H,Liu Q,Shao Y

    更新日期:2006-09-01 00:00:00

  • Lymphocyte subsets and CD45RA positive T-cells in normal canine cerebrospinal fluid.

    abstract::In order to evaluate changes in lymphocyte subpopulations of cerebrospinal fluid (CSF) cells in neurological diseases, normal control data have to be established. In this study we evaluated CSF samples from 65 dogs of both sexes and various breeds with an age range between 5 months and 6 years, and 20 one-year-old hea...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Tipold A,Moore P,Jungi TW,Sager H,Vandevelde M

    更新日期:1998-02-01 00:00:00

  • Characterization of serotonin transporter in blood lymphocytes of rats. Modulation by in vivo administration of mitogens.

    abstract::Serotonin transporter sites were characterized in blood lymphocytes of rats. Pharmacological characteristics of drug interactions were in concordance with recent studies in nervous and human immune cells. The potency order of inhibition of [(3)H]paroxetine binding was imipramine>citalopram>alaproclate>serotonin. Selec...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Cedeño N,Urbina M,Obregón F,Lima L

    更新日期:2005-02-01 00:00:00

  • Major histocompatibility complex class II molecule expression on muscle cells is regulated by differentiation: implications for the immunopathogenesis of muscle autoimmune diseases.

    abstract::Major histocompatibility complex (MHC) class II molecules are expressed on myoblasts after interferon-gamma (IFN-gamma) treatment, suggesting a muscle cell involvement in antigen presentation in inflammatory myopathies. However, they were not observed on normal or pathological myofibers. This discrepancy might be rela...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Mantegazza R,Gebbia M,Mora M,Barresi R,Bernasconi P,Baggi F,Cornelio F

    更新日期:1996-08-01 00:00:00

  • Type 1 immune response in progressive multiple sclerosis.

    abstract::The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4+T-bet+ and CD8+T-bet+ T cells in SPMS and PPMS than in r...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Frisullo G,Plantone D,Marti A,Iorio R,Damato V,Nociti V,Patanella AK,Bianco A,Batocchi AP

    更新日期:2012-08-15 00:00:00

  • Characterization of natural killer cells in paired CSF and blood samples during neuroinflammation.

    abstract::Natural killer (NK) cells from paired CSF and blood samples of patients with multiple sclerosis (MS), other neuroinflammatory diseases (IND), and non-inflammatory neurological diseases (NIND) were characterized using flow cytometry. NK cell frequency in CSF was overall decreased compared to blood, particularly in MS p...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,多中心研究


    authors: Hamann I,Dörr J,Glumm R,Chanvillard C,Janssen A,Millward JM,Paul F,Ransohoff RM,Infante-Duarte C

    更新日期:2013-01-15 00:00:00

  • Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant.

    abstract::Traumatic brain injury triggers a cascade of events resulting in delayed edema, necrosis and impaired function. Harmful mediators are accumulating in the brain after injury and recently, the role of cytokines in the pathophysiology of brain injury has been suggested. We have developed an experimental model for closed ...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章,评审


    authors: Shohami E,Gallily R,Mechoulam R,Bass R,Ben-Hur T

    更新日期:1997-02-01 00:00:00

  • Brain-derived gangliosides induce cell cycle arrest in a murine T cell line.

    abstract::Gangliosides modulate various T cell effector functions through poorly defined mechanisms. To begin to understand one of their effects, the present study examined how normal brain-derived gangliosides suppress T cell proliferation using the murine T cell line, EL4, as a model. Gangliosides inhibited EL4 cell growth by...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Irani DN

    更新日期:1998-07-01 00:00:00

  • Analysis of experimental autoimmune encephalomyelitis induced in F344 rats by pertussis toxin administration.

    abstract::To elucidate the factor(s) accelerating the autoimmune disease processes, we induced two types of experimental autoimmune encephalomyelitis (EAE), severe and very mild, in F344 rats by immunization with myelin basic protein (MBP) plus pertussis toxin (PT) (PT+) or with MBP alone (PT-) and compared the differences betw...

    journal_title:Journal of neuroimmunology

    pub_type: 杂志文章


    authors: Arimoto H,Tanuma N,Jee Y,Miyazawa T,Shima K,Matsumoto Y

    更新日期:2000-04-03 00:00:00