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Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease.

Abstract：

:The B7/CD28:CTLA-4 costimulatory pathway plays a critical role in determining the fate of immune responses (activation vs. down-regulation) and is a highly promising therapeutic target for treating autoimmune diseases. In this review, we highlight the mechanisms by which this costimulatory pathway operates emphasizing the role of the different components in the pathogenesis of relapsing experimental autoimmune encephalomyelitis, a CD4 T cell-mediated autoimmune model of multiple sclerosis. The separate and distinct roles of B7-1, B7-2 and CTLA-4 in positive and negative regulation of autoimmune pathogenesis are considered and a working model is proposed.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Karandikar NJ,Vanderlugt CL,Bluestone JA,Miller SD

doi

10.1016/s0165-5728(98)00058-7

subject

Has Abstract

pub_date

1998-08-14 00:00:00

pages

10-8

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(98)00058-7

journal_volume

89

pub_type

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