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Transient increase in cytokines and nerve growth factor in the rat dorsal root ganglia after nerve lesion and peripheral inflammation.

Abstract：

:Inflammatory response occurs, in general, at the peripheral site of injury or irritation and in the corresponding spinal dorsal horn segments. In this study, we show transient increases in the protein concentrations of interleukins 1beta, 6, 8 and NGF in lumbar DRGs within hours after sciatic mononeuropathy in the rat. Comparable increases, with variation in temporal patterns, were observed after skin inflammation induced by intraplantar injection of endotoxin or complete Freund's adjuvant. The non-matching temporal profiles of cytokines and NGF increases and those of behavioral hypersensitivity, particularly peak values, suggest that the roles of these proteins are not necessarily pro-nociceptive in the DRGs at the chronic phase of neuropathy.

journal_name

J Neuroimmunol

journal_title

Journal of neuroimmunology

authors

Saab CY,Shamaa F,El Sabban ME,Safieh-Garabedian B,Jabbur SJ,Saadé NE

doi

10.1016/j.jneuroim.2009.01.011

subject

Has Abstract

pub_date

2009-03-31 00:00:00

pages

94-103

issue

1-2

eissn

0165-5728

issn

1872-8421

pii

S0165-5728(09)00015-0

journal_volume

208

pub_type

杂志文章

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