Astrocytes support mast cell viability in vitro.

abstract：:Recombinant T cell ligands (RTLs) ameliorate experimental autoimmune encephalomyelitis (EAE) in an antigen-specific manner. We evaluated effects of RTL401 (I-A(s) alpha1beta1+PLP-139-151) on splenocytes from SJL/J mice with EAE to study RTL-T cell tolerance-inducing mechanisms. RTLs bound to B, macrophages and DCs, th...

journal_title：Journal of neuroimmunology

authors： Sinha S,Miller L,Subramanian S,McCarty OJ,Proctor T,Meza-Romero R,Huan J,Burrows GG,Vandenbark AA,Offner H

更新日期：2010-08-25 00:00:00

abstract：:Hemokinin 1 is encoded by preprotachykinin C (PPT-C) mRNA, and has been proposed as a regulator of B and T cell lymphopoiesis. Here we demonstrate the expression of mouse PPT-C mRNA by CD11b+ macrophages, CD11c+ dendritic cells and in the microglial cell line EOC 13.31. Expression was detected in freshly isolated CD11...

journal_title：Journal of neuroimmunology

authors： Nelson DA,Marriott I,Bost KL

更新日期：2004-10-01 00:00:00

abstract：:IL-6 is an important signaling molecule in the CNS. CNS neurons express IL-6 receptors and their signal transduction molecules, consistent with a role for IL-6 in neuronal physiology. Research indicates that IL-6 levels are low in the normal brain but can be significantly elevated in CNS injury and disease. Relatively...

journal_title：Journal of neuroimmunology

authors： Gruol DL,Puro A,Hao C,Blakely P,Janneke E,Vo K

更新日期：2011-10-28 00:00:00

abstract：:We evaluated the presence of soluble (s) CD4 and sCD8, released from activated T cells, in the sera of patients with multiple sclerosis (MS) and human T lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) using an enzyme-linked immunosorbent assay (ELISA). In addition, peripheral blood T cell subsets in pat...

journal_title：Journal of neuroimmunology

authors： Tsukada N,Matsuda M,Miyagi K,Yanagisawa N

更新日期：1991-12-01 00:00:00

abstract：:We investigated in multiple sclerosis the difference between two commonly used oral and intravenous steroid regimens on the level of adhesion molecule expression on blood T lymphocytes, the distribution of circulating T cell subsets, and the concentration of serum tumour necrosis factor alpha. Venous blood samples wer...

journal_title：Journal of neuroimmunology

authors： Pitzalis C,Sharrack B,Gray IA,Lee A,Hughes RA

更新日期：1997-04-01 00:00:00

abstract：:Total glucosides of peony (TGP), an active compound extracted from the roots of Paeonia lactiflora Pall, has wide pharmacological effects on nervous system. Here we examined the effects of TGP on experimental autoimmune encephalomyelitis (EAE), an established model of multiple sclerosis (MS). The results showed that T...

journal_title：Journal of neuroimmunology

authors： Huang Q,Ma X,Zhu DL,Chen L,Jiang Y,Zhou L,Cen L,Pi R,Chen X

更新日期：2015-07-15 00:00:00

abstract：:Thymic tissues express transcripts encoding the alpha-3, alpha-5 and beta-4 subunits of nicotinic neuronal acetylcholine receptors (AcChRs) suggesting that neuronal AcChRs similar to those expressed in ganglia are expressed in the thymus. Transcription occurs in both isolated thymocytes and thymic epithelial cells. RT...

journal_title：Journal of neuroimmunology

authors： Mihovilovic M,Denning S,Mai Y,Whichard LP,Patel DD,Roses AD

更新日期：1997-11-01 00:00:00

abstract：:Tacrolimus-induced encephalopathy presents with acute neurological symptoms such as headache, seizures, visual disturbances, hemiplegia, and altered mental status. A 60-year-old woman, presented to our clinic with a 4-month history of severe headache. She recently underwent kidney transplantation and was taking tacrol...

journal_title：Journal of neuroimmunology

authors： Smeralda CL,Gigli GL,Vogrig A,Marini A,Valente M

更新日期：2019-05-15 00:00:00

abstract：:Failure of CD95-mediated apoptosis as a potential negative regulatory mechanism of T cell expansion may be involved in T cell-mediated autoimmune diseases such as multiple sclerosis (MS). Recently, soluble CD95 has been shown to be elevated in MS patients with active disease. Here, we report that the sera of MS patien...

journal_title：Journal of neuroimmunology

authors： Zipp F,Otzelberger K,Dichgans J,Martin R,Weller M

更新日期：1998-06-15 00:00:00

abstract：:CCR7 and CD45RA expression on CD4+ and CD8+ T-cells in blood (PB) of 16 patients with multiple sclerosis (MS) and 16 healthy controls and cerebrospinal fluid (CSF) of 10 patients suffering from MS were analysed by flow cytometric measurements. T-cells were divided by their distinct homing potentials and effector-funct...

journal_title：Journal of neuroimmunology

authors： Haegele KF,Stueckle CA,Malin JP,Sindern E

更新日期：2007-02-01 00:00:00

abstract：:Splice variants of CD44 molecule-harboring exon 10 (v6), often called v6 variants (v6v), are shown to confer tumor progressive, metastatic or invasive capacities. Furthermore, CD44 molecule on activated T-cells are shown to be required for infiltration of these cells into the inflammatory site and for accelerated immu...

journal_title：Journal of neuroimmunology

authors： Matsuoka E,Usuku K,Jonosono M,Takenouchi N,Izumo S,Osame M

更新日期：2000-01-03 00:00:00

abstract：:In addition to a clear genetic disposition, environmental factors and viral infections are thought to play a role in the pathogenesis of autoimmune diseases such as type I diabetes or multiple sclerosis (MS). This article will explore, by use of paradigms developed in a transgenic mouse model, why it has been so diffi...

journal_title：Journal of neuroimmunology

authors： von Herrath MG

更新日期：2000-07-24 00:00:00

abstract：:Contradictory results have been reported regarding the role of inflammatory mediators in the central nervous system in mediating neuropathic pain and inflammatory hyperalgesia following peripheral nerve injury or localized inflammation. The present study aims to correlate between the mRNA expression and protein secret...

journal_title：Journal of neuroimmunology

authors： Chamaa F,Chebaro M,Safieh-Garabedian B,Saadeh R,Jabbur SJ,Saadé NE

更新日期：2016-08-15 00:00:00

abstract：:In addition to the major histocompatibility complex (MHC), genetic susceptibility in multiple sclerosis (MS) appears to be influenced by other loci. A recent study has identified a population association with an immunoglobulin heavy chain variable region polymorphism in the VH2-B5 family, with both familial and sporad...

journal_title：Journal of neuroimmunology

authors： Hashimoto LL,Walter MA,Cox DW,Ebers GC

更新日期：1993-04-01 00:00:00

abstract：:The expression of class I major histocompatibility complex (MHC) mRNA was compared in the brains of inflammatory susceptible, hypothalamic-pituitary-adrenal (HPA)-axis blunted Lewis rats and inflammatory resistant, HPA-axis hyperresponsive Fischer rats by quantitative in situ hybridization following lipopolysaccharide...

journal_title：Journal of neuroimmunology

authors： Puchowicz M,Tonelli LH,Sternberg EM

更新日期：2003-01-01 00:00:00

abstract：:We have shown earlier that induction of experimental autoimmune encephalomyelitis (EAE)-a model for the human disease multiple sclerosis-in C57BL/6 wild-type mice resulted in the expression of the p75 low-affinity neurotrophin receptor (p75NTR) in endothelial cells in the CNS. In comparison to the clinical manifestati...

journal_title：Journal of neuroimmunology

authors： Küst B,Mantingh-Otter I,Boddeke E,Copray S

更新日期：2006-05-01 00:00:00

abstract：:The enzyme heme oxygenase-1 (HO-1) is reducing heme to the gaseous mediator carbon monoxide, to iron and the antioxidant biliverdin. The inducible expression of HO-1 is considered a protective cellular mechanism against reactive oxygen intermediates. Further, carbon monoxide (CO) is a regulator of cGMP synthesis, of N...

journal_title：Journal of neuroimmunology

authors： Schluesener HJ,Seid K

更新日期：2000-10-02 00:00:00

abstract：:Schizophrenia is a heterogeneous disorder and its etiology remains incompletely elucidated. Among possible causes, immunological factors have been implicated in its pathogenesis and course. The inflammatory system may trigger or modulate the course of schizophrenia through complex mechanisms influencing neurodevelopme...

journal_title：Journal of neuroimmunology

authors： Kapelski P,Skibinska M,Maciukiewicz M,Pawlak J,Permoda-Osip A,Twarowska-Hauser J

更新日期：2015-08-15 00:00:00

abstract：:HLA-DR expression on circulating monocytes varies as a function of disease activity in patients with multiple sclerosis (MS), a putative immunopathological demyelinating disorder. Specifically, monocytes isolated from subjects with active MS exhibit reduced HLA-DR antigen density, and immunoregulatory aberrations such...

journal_title：Journal of neuroimmunology

authors： Ransohoff RM,Tuohy VK,Barna BP,Rudick RA

更新日期：1992-04-01 00:00:00

abstract：:It is widely believed that multiple sclerosis is a T-cell mediated autoimmune disease associated with abnormalities in immunoregulation. This large, prospective study evaluated the lymphocyte immunophenotypic profile of 246 MS patients, divided clinically into a remitting/relapsing group (n = 176) and a progressive gr...

journal_title：Journal of neuroimmunology

authors： Strauss K,Hulstaert F,Deneys V,Mazzon AM,Hannet I,De Bruyère M,Reichert T,Sindic CJ

更新日期：1995-12-31 00:00:00

abstract：:The aim of this study was to evaluate a possible role of soluble CD14 (sCD14) in multiple sclerosis (MS). We found that sCD14 serum levels measured by ELISA were higher in MS patients compared to neurological and healthy controls. Within the MS group sCD14 levels were increased in relapsing-remitting and secondary pro...

journal_title：Journal of neuroimmunology

authors： Lutterotti A,Kuenz B,Gredler V,Khalil M,Ehling R,Gneiss C,Egg R,Deisenhammer F,Berger T,Reindl M

更新日期：2006-12-01 00:00:00

abstract：:Despite a number of new therapies that are effective in reducing the inflammatory component of multiple sclerosis, the underlying cause of the disease remains uncertain. One of the most powerful tools available to an investigator to help in unraveling the underlying disease mechanisms in MS is the incorporation of car...

journal_title：Journal of neuroimmunology

authors： McFarland H

更新日期：2011-02-01 00:00:00

abstract：:High titer antibodies primarily of the IgG class were produced against galactocerebroside (GalC) by including keyhole limpet hemocyanin (KLH) and supplemental M. tuberculosis in the adjuvant mixture used for immunization of rabbits. Antibody titers were determined by an ELISA in which microtiter wells were coated with...

journal_title：Journal of neuroimmunology

authors： Benjamins JA,Callahan RE,Montgomery IN,Studzinski DM,Dyer CA

更新日期：1987-04-01 00:00:00

abstract：:Interferon-β (IFN-β) is often discontinued in RRMS patients due to its most common side effect, the flu-like syndrome (FLS). The mechanisms underlying IFN β-induced FLS symptoms are still unclear. The endocannabinoid system (ECS) is a key regulator of pain and inflammation. Thus we tested the hypothesis that the ECS c...

journal_title：Journal of neuroimmunology

authors： Buttari F,Zagaglia S,Marciano L,Albanese M,Landi D,Nicoletti CG,Mercuri NB,Silvestrini M,Provinciali L,Marfia GA,Mori F,Centonze D

更新日期：2017-04-15 00:00:00

abstract：:Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Escherichia coli heat-labile enterotoxin adjuvant-laden immunostimulato...

journal_title：Journal of neuroimmunology

authors： Davtyan H,Ghochikyan A,Hovakimyan A,Petrushina I,Yu J,Flyer D,Madsen PJ,Pedersen LO,Cribbs DH,Agadjanyan MG

更新日期：2014-03-15 00:00:00

abstract：:The capacity of rat cerebral endothelial cells (RCEC) to form eicosanoids was determined after incubation with 14C-labelled arachidonic acid. Prostaglandin E2 (PGE2) was the main metabolite formed by RCEC and was responsible for 54% of the total amount of eicosanoids produced. In contrast, in primary cultures of rat a...

journal_title：Journal of neuroimmunology

authors： de Vries HE,Hoogendoorn KH,van Dijk J,Zijlstra FJ,van Dam AM,Breimer DD,van Berkel TJ,de Boer AG,Kuiper J

更新日期：1995-06-01 00:00:00

abstract：:Astrocytic cells of unusual aspect can be detected in the cerebellum of normal mice during the first 4 weeks of life. They are visualized with anti-GFAP (glial fibrillary acidic protein), anti-S100 and anti-vimentin immune sera. Their perikaryons, located in the white matter or in the granular layer, extend long proce...

journal_title：Journal of neuroimmunology

authors： Benjelloun-Touimi S,Jacque CM,Derer P,De Vitry F,Maunoury R,Dupouey P

更新日期：1985-07-01 00:00:00

abstract：:Using congenic strains of mice susceptible (bcg(s)) or resistant (bcg(r)) to BCG, murine microglial cell lines, RR4.R (BCG-resistant) and RR8.S (BCG-susceptible), were established in vitro. Comparative studies revealed that, although phagocytic to a similar extent, RR4.R cells were more active than RR8.S cells in term...

journal_title：Journal of neuroimmunology

authors： Puliti M,Mazzolla R,Brozzetti A,Neglia R,Radzioch D,Bistoni F,Blasi E

更新日期：1999-11-01 00:00:00

abstract：:The common acute lymphoblastic leukemia antigen (CALLA), CD10, is a 100-kDa surface glycoprotein endowed with neutral endopeptidase activity, shared by a number of hemopoietic and non-hemopoietic cells. In this report, immunohistochemical and Western blot techniques, using different anti-CD10 monoclonal antibodies, we...

journal_title：Journal of neuroimmunology

authors： Cadoni A,Mancardi GL,Zaccheo D,Nocera A,Barocci S,Bianchini D,Schenone A,Capello E,Zicca A

更新日期：1993-06-01 00:00:00

abstract：:Neuroendocrine system and immune system can communicate via the use of soluble mediators like hormones, neurotransmitters and cytokines. The level of mediators secreted by either of these systems creates the milieu in which immune and neuroendocrine responses take place. For adequate communication between the systems,...

journal_title：Journal of neuroimmunology

authors： Heijnen CJ,Kavelaars A

更新日期：1999-12-01 00:00:00